Stem cell models of human synapse development and degeneration

Are endocrine disrupting compounds environmental risk factors for autism spectrum disorder?

(2018) Amer Moosa et al.   HORMONES AND BEHAVIOR

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling

(2018) Yunyao Xie et al.   Stem Cell Research

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro

(2017) Bruno H. S. Araujo et al.   MOLECULAR NEUROBIOLOGY

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

(2017) N Gunhanlar et al.   MOLECULAR PSYCHIATRY

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

A Review of the Safety, Efficacy and Mechanisms of Delivery of Nasal Oxytocin in Children: Therapeutic Potential for Autism and Prader-Willi Syndrome, and Recommendations for Future Research

(2017) Marilena M. DeMayo et al.   PEDIATRIC DRUGS

Derivation of Functional Human Astrocytes from Cerebral Organoids

(2017) Rômulo Sperduto Dezonne et al.   Scientific Reports

Shifting brain inhibitory balance and connectivity of the prefrontal cortex of adults with autism spectrum disorder

(2017) L A Ajram et al.   Translational Psychiatry

Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells

(2017) Xiaohong Xu et al.   Stem Cell Reports

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

(2017) Panchanan Maiti et al.   Translational Neurodegeneration

Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells

(2017) Aishwarya G. Nadadhur et al.   PLoS One

On-demand optogenetic activation of human stem-cell-derived neurons

(2017) Simon D. Klapper et al.   Scientific Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Stem Cell Models of Human Brain Development

(2016) Iva Kelava et al.   Cell Stem Cell

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

(2016) M C Marchetto et al.   MOLECULAR PSYCHIATRY

Review: Parkinson's disease: from synaptic loss to connectome dysfunction

(2016) Arianna Bellucci et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome

(2016) Xin Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions

(2016) Heiko J. Luhmann et al.   Frontiers in Neural Circuits

Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture

(2016) A. Odawara et al.   Scientific Reports

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation

(2016) Elsa Vera et al.   Cell Reports

The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2

(2016) Marianna Leonzino et al.   Cell Reports

Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies

(2015) Michael W. Nestor et al.   Autism Research

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

(2015) S. Sivakumaran et al.   JOURNAL OF NEUROSCIENCE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Schizophrenia: a tale of two critical periods for prefrontal cortical development

(2015) L D Selemon et al.   Translational Psychiatry

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

(2014) K Griesi-Oliveira et al.   MOLECULAR PSYCHIATRY

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

The GABA excitatory/inhibitory developmental sequence: A personal journey

(2014) Y. Ben-Ari   NEUROSCIENCE

Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols

(2014) Christina R. Muratore et al.   PLoS One

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

(2013) Jocelyn F Krey et al.   NATURE NEUROSCIENCE

AMPA-silent synapses in brain development and pathology

(2013) Eric Hanse et al.   NATURE REVIEWS NEUROSCIENCE

Molecular mechanisms of dendrite stability

(2013) Anthony J. Koleske   NATURE REVIEWS NEUROSCIENCE

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Stimulation of GABA-Induced Ca2+ Influx Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Neurons

(2013) David J. Rushton et al.   PLoS One

Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

(2013) Xin Tang et al.   Stem Cell Research

Role of cerebral cortex in the neuropathology of Huntington's disease

(2013) Ana M. Estrada-Sánchez et al.   Frontiers in Neural Circuits

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Evidence of neurodegeneration in autism spectrum disorder

(2013) Janet K Kern et al.   Translational Neurodegeneration

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Methods of dendritic spine detection: From Golgi to high-resolution optical imaging

(2012) J.J. Mancuso et al.   NEUROSCIENCE

Prolonged myelination in human neocortical evolution

(2012) D. J. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

(2011) Ricardo Dolmetsch et al.   CELL

Spontaneous Electrical Activity in the Human Fetal Cortex In Vitro

(2011) A. R. Moore et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

(2011) Zdravko Petanjek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptopathy: dysfunction of synaptic function?

(2010) Nils Brose et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

(2009) Jeffrey J. Hutsler et al.   BRAIN RESEARCH

Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies

(2009) David A. Lewis et al.   JOURNAL OF CLINICAL INVESTIGATION

KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent Manner

(2009) Dante Bortone et al.   NEURON

Normal Development of Brain Circuits

(2009) Gregory Z Tau et al.   NEUROPSYCHOPHARMACOLOGY

Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

(2008) Robert A Sweet et al.   NEUROPSYCHOPHARMACOLOGY