Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

(2019) Jonathan Hasselmann et al.   NEURON

Niche signals and transcription factors involved in tissue-resident macrophage development

(2018) Wouter T'Jonck et al.   CELLULAR IMMUNOLOGY

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections

(2018) Julien Muffat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

(2018) Philip W. Brownjohn et al.   Stem Cell Reports

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

(2018) Jerome Mertens et al.   Annual Review of Genetics

The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

(2018) Xianyuan Xiang et al.   Molecular Neurodegeneration

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

(2018) Pablo Garcia-Reitboeck et al.   Cell Reports

Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2

(2018) Christel Claes et al.   Alzheimers & Dementia

Pathological Changes in Alzheimer’s Disease Analyzed Using Induced Pluripotent Stem Cell-Derived Human Microglia-Like Cells

(2018) Mei Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Development and validation of a simplified method to generate human microglia from pluripotent stem cells

(2018) Amanda McQuade et al.   Molecular Neurodegeneration

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis

(2017) Georges Lacaud et al.   EXPERIMENTAL HEMATOLOGY

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

(2017) Kazuyuki Takata et al.   IMMUNITY

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Elucidating the Role of TREM2 in Alzheimer’s Disease

(2017) Jason D. Ulrich et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

The Lifespan and Turnover of Microglia in the Human Brain

(2017) Pedro Réu et al.   Cell Reports

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB -Independent Tissue-Resident Macrophages

(2017) Julian Buchrieser et al.   Stem Cell Reports

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

(2017) Panagiotis Douvaras et al.   Stem Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Isolation of primary microglia from the human post-mortem brain: effects of ante- and post-mortem variables

(2017) Mark R. Mizee et al.   Acta Neuropathologica Communications

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

Molecular control of activation and priming in macrophages

(2016) Christopher K Glass et al.   NATURE IMMUNOLOGY

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

A view of human haematopoietic development from the Petri dish

(2016) Andrea Ditadi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Early hematopoiesis and macrophage development

(2015) Kathleen E. McGrath et al.   SEMINARS IN IMMUNOLOGY

Microglia in Health and Disease

(2015) Richard M. Ransohoff et al.   Cold Spring Harbor Perspectives in Biology

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo

(2015) Kathleen E. McGrath et al.   Cell Reports

Ontogeny of Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   Frontiers in Immunology

NANOG and CDX2 Pattern Distinct Subtypes of Human Mesoderm during Exit from Pluripotency

(2014) Sasha Mendjan et al.   Cell Stem Cell

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

(2014) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

The human side of microglia

(2014) Amy M. Smith et al.   TRENDS IN NEUROSCIENCES

Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease

(2014) Masahiro Ohgidani et al.   Scientific Reports

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Robust and Highly-Efficient Differentiation of Functional Monocytic Cells from Human Pluripotent Stem Cells under Serum- and Feeder Cell-Free Conditions

(2013) Masakatsu D. Yanagimachi et al.   PLoS One

Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions

(2013) Bonnie van Wilgenburg et al.   PLoS One

Comparison of polarization properties of human adult microglia and blood-derived macrophages

(2012) Bryce A. Durafourt et al.   GLIA

Phenotyping primary human microglia: Tight regulation of LPS responsiveness

(2012) Jeroen Melief et al.   GLIA

A novel in vitro human microglia model: Characterization of human monocyte-derived microglia

(2012) Samar Etemad et al.   JOURNAL OF NEUROSCIENCE METHODS

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Identification and Characterization of Enhancers Controlling the Inflammatory Gene Expression Program in Macrophages

(2010) Serena Ghisletti et al.   IMMUNITY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3

(2008) Karl R. Karlsson et al.   EXPERIMENTAL HEMATOLOGY