Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”

DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury

(2021) Federica De Lazzari et al.   Redox Biology

Protective effect of Hydralazine on a cellular model of Parkinson's disease: a possible role of hypoxia-inducible factor (HIF)-1α

(2020) Mehrnaz Mehrabani et al.   Biochemistry and Cell Biology

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease

(2020) Pascaline Aimé et al.   NEUROBIOLOGY OF DISEASE

The relationship between obstructive sleep apnea and Parkinson’s disease: a systematic review and meta-analysis

(2020) A-Ping Sun et al.   NEUROLOGICAL SCIENCES

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

(2020) Chris McKinnon et al.   Acta Neuropathologica Communications

Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

(2020) Liangqin Shi et al.   Aging-US

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

(2020) Manoj Kumar et al.   Stem Cell Reports

HIF-1α protects against oxidative stress by directly targeting mitochondria

(2019) Hong-Sheng Li et al.   Redox Biology

Plasma α -synuclein levels are increased in patients with obstructive sleep apnea syndrome

(2019) Hao-Lun Sun et al.   Annals of Clinical and Translational Neurology

Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration

(2019) Junhui Zhang et al.   Cell Death & Disease

Hypoxia-induced 26S proteasome dysfunction increases immunogenicity of mesenchymal stem cells

(2019) Ejlal Abu-El-Rub et al.   Cell Death & Disease

Inactivating the ubiquitin ligase Parkin suppresses cell proliferation and induces apoptosis in human keloids

(2019) Rui Lei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders

(2019) Yan‐Rong Zheng et al.   CNS Neuroscience & Therapeutics

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease

(2019) Ludmila P. Dolgacheva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Up-regulation of HIF-1α is associated with neuroprotective effects of agmatine against rotenone-induced toxicity in differentiated SH-SY5Y cells

(2019) Nadia Ferlazzo et al.   AMINO ACIDS

Hypoxia and aging

(2019) Eui-Ju Yeo   EXPERIMENTAL AND MOLECULAR MEDICINE

Autophagy dysfunction in peripheral blood mononuclear cells of Parkinson’s disease patients

(2019) Nikolaos Papagiannakis et al.   NEUROSCIENCE LETTERS

Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson’s Disease Models

(2019) Hefeng Zhou et al.   Neurotherapeutics

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

(2019) Benjamin G. Trist et al.   AGING CELL

Hypoxia‐inducible factor 1 alpha and nuclear‐related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease

(2019) Esraa A. Kandil et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction

(2019) Jyotirmoy Rakshit et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The genetic architecture of Parkinson's disease

(2019) Cornelis Blauwendraat et al.   LANCET NEUROLOGY

Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction

(2019) Shu Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Multinucleated polyploid cardiomyocytes undergo an enhanced adaptability to hypoxia via mitophagy

(2019) Yun-Han Jiang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway

(2019) David Kung-Chun Chiu et al.   Cell Death & Disease

Autophagy and LRRK2 in the Aging Brain

(2019) Federica Albanese et al.   Frontiers in Neuroscience

Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process

(2018) Amin Karimi-Moghadam et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Activating Autophagy as a Therapeutic Strategy for Parkinson’s Disease

(2018) Alan J. Fowler et al.   CNS DRUGS

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Chloroquine inhibits autophagy and deteriorates the mitochondrial dysfunction and apoptosis in hypoxic rat neurons

(2018) Peng Li et al.   LIFE SCIENCES

Mild TBI and risk of Parkinson disease

(2018) Raquel C. Gardner et al.   NEUROLOGY

Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson’s disease

(2018) Anand Rane et al.   NEUROTOXICOLOGY

Early occurrence of inspiratory muscle weakness in Parkinson’s disease

(2018) Guillaume Baille et al.   PLoS One

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

(2018) Iryna Prots et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson’s Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function

(2018) Xuan Li et al.   Frontiers in Aging Neuroscience

Oxidative Stress in Parkinson's Disease: A Systematic Review and Meta-Analysis

(2018) Zexu Wei et al.   Frontiers in Molecular Neuroscience

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

(2018) Tao Li et al.   Frontiers in Pharmacology

δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways

(2018) Tao Chen et al.   MOLECULAR NEUROBIOLOGY

Understanding multifactorial architecture of Parkinson’s disease: pathophysiology to management

(2018) Ramandeep Kaur et al.   NEUROLOGICAL SCIENCES

The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease

(2018) Minrui Weng et al.   Parkinsons Disease

Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

(2018) Fatemeh N. Emamzadeh et al.   Frontiers in Neuroscience

ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

(2018) Ruoxi Wang et al.   JOURNAL OF CELL BIOLOGY

The insights into molecular pathways of hypoxia‐inducible factor in the brain

(2018) Robert P. Ostrowski et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage

(2018) Yun-Hee Bae et al.   Cell Death & Disease

DJ-1 promotes survival of human colon cancer cells under hypoxia by modulating HIF-1α expression through the PI3K-AKT pathway

(2018) Hong Zheng et al.   Cancer Management and Research

Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice

(2018) Shuang-Feng Xu et al.   Redox Biology

Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction

(2017) Samer Tohme et al.   HEPATOLOGY

Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson’s Disease

(2017) Tingting Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Α-synuclein induces microglial cell migration through stimulating HIF-1α accumulation

(2017) Hongfei Qiao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Aging and Parkinson's disease: Different sides of the same coin?

(2017) Timothy J. Collier et al.   MOVEMENT DISORDERS

Selective neuronal vulnerability in Parkinson disease

(2017) D. James Surmeier et al.   NATURE REVIEWS NEUROSCIENCE

Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

(2017) Alice Biosa et al.   NEUROBIOLOGY OF DISEASE

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

(2017) Juan Liu et al.   Nature Communications

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Differential impact of various reactive oxygen species (ROS) on HIF-1α/p53 direct interaction in SK-N-MC neuroblastoma cells

(2017) Elham Parandavar et al.   Cell and Bioscience

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

(2017) Yunjong Lee et al.   Cell Reports

Autonomic Function Impairment and Brain Perfusion Deficit in Parkinson’s Disease

(2017) Wei-Che Lin et al.   Frontiers in Neurology

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria

(2017) Luke W. Thomas et al.   Frontiers in Oncology

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson’s disease

(2017) Brianada Koentjoro et al.   Scientific Reports

Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia

(2016) José López-Barneo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro

(2016) Grazia Maugeri et al.   CELL AND TISSUE RESEARCH

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

(2016) Chuang Guo et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

(2016) Tongmei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

(2016) Kenneth R. Pryde et al.   JOURNAL OF CELL BIOLOGY

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of ATP13A2 via PHD2-HIF1  Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease

(2016) S. Rajagopalan et al.   JOURNAL OF NEUROSCIENCE

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

(2016) Hong Jiang et al.   MOLECULAR NEUROBIOLOGY

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism

(2016) LAN GUI et al.   Experimental and Therapeutic Medicine

The Parkinson’s disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

(2016) Carla F. Bento et al.   Nature Communications

Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson’s disease

(2016) Pingping Song et al.   Protein & Cell

Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra

(2016) Nannan Yang et al.   Scientific Reports

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

(2015) David I. Finkelstein et al.   ACS Chemical Neuroscience

Biological and physiological role of reactive oxygen species - the good, the bad and the ugly

(2015) L. Zuo et al.   Acta Physiologica

DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulatingpink1

(2015) Raquel Requejo-Aguilar et al.   BIOCHEMICAL JOURNAL

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Parkin structure and function

(2015) Marjan Seirafi et al.   FEBS Journal

Cellular processes associated with LRRK2 function and dysfunction

(2015) Rebecca Wallings et al.   FEBS Journal

Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate

(2015) Shahrzad Movafagh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia-inducible factor-1α upregulates tyrosine hydroxylase and dopamine transporter by nuclear receptor ERRγ in SH-SY5Y cells

(2015) Juhee Lim et al.   NEUROREPORT

Ameliorative effects of baicalein in MPTP-induced mouse model of Parkinson's disease: A microarray study

(2015) Li Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson’s disease model

(2015) S Kasai et al.   Cell Death & Disease

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

(2015) Edward L. LaGory et al.   Cell Reports

Intranasally-administered deferoxamine mitigates toxicity of 6-OHDA in a rat model of Parkinson׳s disease

(2014) J.M. Fine et al.   BRAIN RESEARCH

Loss of PINK1 Attenuates HIF-1  Induction by Preventing 4E-BP1-Dependent Switch in Protein Translation under Hypoxia

(2014) W. Lin et al.   JOURNAL OF NEUROSCIENCE

Regulation of the VHL/HIF-1 Pathway by DJ-1

(2014) M. Parsanejad et al.   JOURNAL OF NEUROSCIENCE

Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease

(2014) Ya Feng et al.   NEUROSCIENCE LETTERS

Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells

(2014) YU-YING WAN et al.   ONCOLOGY REPORTS

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1

(2014) Raquel Requejo-Aguilar et al.   Nature Communications

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

(2014) Sarah van Veen et al.   Frontiers in Molecular Neuroscience

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model

(2013) Fabia Febbraro et al.   EXPERIMENTAL NEUROLOGY

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

 -Synuclein in CSF of patients with severe traumatic brain injury

(2013) S. Mondello et al.   NEUROLOGY

Intermittent Hypoxia Can Aggravate Motor Neuronal Loss and Cognitive Dysfunction in ALS Mice

(2013) Sung-Min Kim et al.   PLoS One

Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria

(2013) H.-J. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Hypoxia regulation of ATP13A2 (PARK9) gene transcription

(2012) Qian Xu et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowth

(2012) Chengyu Sheng et al.   NEUROBIOLOGY OF AGING

Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival

(2012) Eisuke Dohi et al.   NEUROCHEMISTRY INTERNATIONAL

HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia

(2012) Salvador Naranjo-Suarez et al.   PLoS One

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Recent advances and contraversies on the role of pulmonary neuroepithelial bodies as airway sensors

(2012) Ernest Cutz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell death

(2011) Matthias Elstner et al.   ACTA NEUROPATHOLOGICA

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Hypoxia Inducible Factor-1 as a Target for Neurodegenerative Diseases

(2011) Z. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells

(2011) Ji Hye Kim et al.   STEM CELLS AND DEVELOPMENT

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

The human side of hypoxia-inducible factor

(2010) Thomas G. Smith et al.   BRITISH JOURNAL OF HAEMATOLOGY

Role of the hypoxia inducible factors HIF in iron metabolism

(2010) Carole Peyssonnaux et al.   CELL CYCLE

The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

(2010) S Michiorri et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients

(2010) Lingyun Zhu et al.   CELL RESEARCH

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

(2010) Thomas Landes et al.   EMBO REPORTS

Mitochondrial fission and fusion

(2010) Iain Scott et al.   Essays in Biochemistry

Parkinson Disease-associated DJ-1 Is Required for the Expression of the Glial Cell Line-derived Neurotrophic Factor Receptor RET in Human Neuroblastoma Cells

(2010) Rossana Foti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson's disease

(2010) Ashley R. Winslow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration

(2010) David T. Dexter et al.   JOURNAL OF NEURAL TRANSMISSION

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells

(2010) Jens Leander Johansen et al.   JOURNAL OF NEUROCHEMISTRY

Parkin Directly Modulates 26S Proteasome Activity

(2010) J. W. Um et al.   JOURNAL OF NEUROSCIENCE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1α and induction of autophagy in SH-SY5Y cells

(2010) Yuncheng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

(2010) Guido Krebiehl et al.   PLoS One

Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain

(2009) Obinna I. Ndubuizu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking†

(2009) Andreas Weihofen et al.   BIOCHEMISTRY

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

PINK1 function in health and disease

(2009) Emma Deas et al.   EMBO Molecular Medicine

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

(2009) Donna W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation

(2009) A. Kathrin Lutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HUMMR, a hypoxia- and HIF-1α–inducible protein, alters mitochondrial distribution and transport

(2009) Yan Li et al.   JOURNAL OF CELL BIOLOGY

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

(2009) Johanna Chiche et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo

(2009) Louise Witten et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Impaired Expression of Neuroprotective Molecules in the HIF-1α Pathway following Traumatic Brain Injury in Aged Mice

(2009) Joshua Anderson et al.   JOURNAL OF NEUROTRAUMA

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle

(2009) Kristen A Malkus et al.   Molecular Neurodegeneration

Restoration of Nigrostriatal Dopamine Neurons in Post-MPTP Treatment by the Novel Multifunctional Brain-Permeable Iron Chelator-Monoamine Oxidase Inhibitor Drug, M30

(2009) Shunit Gal et al.   NEUROTOXICITY RESEARCH

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression

(2009) Jolene Bohensky et al.   PEDIATRIC NEPHROLOGY

Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells

(2009) Matthew E. Gegg et al.   PLoS One

PGC-1  is coupled to HIF-1 -dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

(2009) K. A. O'Hagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Eaten Alive

(2008) Charleen T. Chu   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3 and BNIP3L

(2008) I Papandreou et al.   CELL DEATH AND DIFFERENTIATION

Decreased Vascular Repair and Neovascularization with Ageing: Mechanisms and Clinical Relevance with an Emphasis on Hypoxia- Inducible Factor-1

(2008) Michel Hoenig et al.   CURRENT MOLECULAR MEDICINE

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Hypoxia Stimulates Mitochondrial Biogenesis in Brain Subcortex by a Neuronal Nitric Oxide Synthase-Dependent Mechanism

(2008) D. R. Gutsaeva et al.   JOURNAL OF NEUROSCIENCE

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

(2008) Silvia Carloni et al.   NEUROBIOLOGY OF DISEASE

Parkinson's disease and pesticides: a toxicological perspective

(2008) J HATCHER et al.   TRENDS IN PHARMACOLOGICAL SCIENCES