Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

(2019) Michael X. Henderson et al.   Acta Neuropathologica Communications

The vicious cycle between α ‐synuclein aggregation and autophagic‐lysosomal dysfunction

(2019) Giovanni Bellomo et al.   MOVEMENT DISORDERS

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

(2017) Amani Alghamdi et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

(2017) Ahmed Yousef et al.   Acta Neuropathologica Communications

Impairment of proteasome and anti-oxidative pathways in the induced pluripotent stem cell model for sporadic Parkinson's disease

(2016) Kuo-Hsuan Chang et al.   PARKINSONISM & RELATED DISORDERS

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction

(2015) Jada H Vaden et al.   Molecular Neurodegeneration

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein

(2015) Eduard Bentea et al.   Frontiers in Behavioral Neuroscience

The Ubiquitin-Proteasome System in Neurodegeneration

(2014) Chris McKinnon et al.   ANTIOXIDANTS & REDOX SIGNALING

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein

(2014) DANMEI LAN et al.   Molecular Medicine Reports

Adaptive changes in autophagy after UPS impairment in Parkinson's disease

(2013) Yu-fei Shen et al.   ACTA PHARMACOLOGICA SINICA

Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein

(2013) Fang Yang et al.   ACTA PHARMACOLOGICA SINICA

α-Synuclein oligomers and clinical implications for Parkinson disease

(2012) Lorraine V. Kalia et al.   ANNALS OF NEUROLOGY

Phosphorylation of α-synuclein is crucial in compensating for proteasomal dysfunction

(2012) Hee soon Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

(2012) Shubhangi Prabhudesai et al.   Neurotherapeutics

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

(2011) James B. Koprich et al.   PLoS One

A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy

(2010) Salma Bukhatwa et al.   BRAIN RESEARCH

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease

(2010) James B Koprich et al.   Molecular Neurodegeneration

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

A Cellular Model To Monitor Proteasome Dysfunction by α-Synuclein

(2009) Takashi Nonaka et al.   BIOCHEMISTRY

Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson’s disease pathogenesis

(2009) Kai-Yin Chau et al.   JOURNAL OF NEUROCHEMISTRY

Reciprocal Effects of α-Synuclein Overexpression and Proteasome Inhibition in Neuronal Cells and Tissue

(2009) Melanie Dyllick-Brenzinger et al.   NEUROTOXICITY RESEARCH

Limitations of SLLVY-AMC in calpain and proteasome measurements

(2008) Christopher J. Giguere et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Cell-produced α-synuclein oligomers are targeted to, and impair, the 26S proteasome

(2008) Evangelia Emmanouilidou et al.   NEUROBIOLOGY OF AGING