Article
Medicine, General & Internal
Yuhang Zhu, Fangfang Wang, Jue Zhou, Shuiqin Gu, Lianqing Gong, Yaoyao Lin, Xiaoli Hu, Wei Wang, Aihua Zhang, Dongmei Ma, Chunxiao Hu, Yan Wu, Lanzhong Guo, Limin Chen, Leiyin Cen, Yan He, Yuqing Cai, Enli Wang, Honglou Chen, Jing Jin, Jinhe Huang, Meiyuan Jin, Xiujuan Sun, Xiaojiao Ye, Linping Jiang, Ying Zhang, Jian Zhang, Junfei Lin, Chunping Zhang, Guofang Shen, Wei Jiang, Liuyan Zhong, Yuefang Zhou, Ruoya Wu, Shiqing Lu, Linlin Feng, Hong Guo, Shanhu Lin, Qiaosu Chen, Jinfang Kong, Xuan Yang, Mengling Tang, Chang Liu, Fang Wang, Xiao-Yang Mio Hu, Hye Won Lee, Xinfen Xu, Rong Zhang, Nicola Robinson, Myeong Soo Lee, Jisheng Han, Fan Qu
Summary: This multicenter randomized clinical trial in China showed that acupoint hot compress may reduce postpartum urinary retention, alleviate uterine contraction pain, improve depressive symptoms, and increase breastfeeding milk volume.
Article
Clinical Neurology
Mariana Fortunata Donadon, Rocio Martin-Santos, Flavia L. Osorio
Summary: The study assessed the effects of intranasal oxytocin on facial emotion recognition and negative thoughts in mothers with postpartum depression. While oxytocin did not affect facial emotion recognition, it did reduce negative thoughts, especially in mothers with PPD.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Sarah Averbach, Gennifer Kully, Erica Hinz, Arnab Dey, Holly Berkley, Marisa Hildebrand, Florin Vaida, Sadia Haider, Lisa G. Hofler
Summary: This study compared the rates of expulsion for intrauterine devices (IUDs) placed early postpartum (2-4 weeks after birth) with those placed at the standard interval (6-8 weeks postpartum). The study found that at the 6-month follow-up, the complete expulsion rate for the early placement group was 2.0%, while it was 0% for the interval placement group. The partial expulsion rate was 9.4% for the early placement group and 7.6% for the interval placement group. Therefore, understanding the expulsion risk at these time points can help patients and clinicians make informed decisions about the timing of IUD placement.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Anna Roca, Bully Camara, Joel D. Bognini, Usman N. Nakakana, Athasana M. Some, Nathalie Beloum, Toussaint Rouamba, Fatoumata Sillah, Madikoi Danso, Joquina C. Jones, Shashu Graves, Isatou Jagne, Pauline Getanda, Saffiatou Darboe, Marc C. Tahita, Ebrahim Ndure, Hien S. Franck, Sawadogo Y. Edmond, Bai L. Dondeh, Wilfried G. J. Nassa, Zakaria Garba, Abdoulie Bojang, Yusupha Njie, Christian Bottomley, Halidou Tinto, Umberto D'Alessandro
Summary: This double-blind, placebo-controlled, randomized clinical trial aimed to evaluate the efficacy of intrapartum azithromycin in reducing neonatal sepsis or mortality, as well as its impact on neonatal and maternal infections. The trial results showed that oral intrapartum azithromycin did not reduce the incidence of neonatal sepsis or mortality, suggesting it should not be routinely used for this purpose.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Xuan Che, Jianzhang Wang, Wenting Sun, Jiayi He, Qiming Wang, Danyang Zhu, Weili Zhu, Jing Zhang, Jie Dong, Jingui Xu, Feiyun Zheng, Jianwei Zhou, Weidong Zhao, Qiao Lin, Lingfang Ye, Xiumin Zhao, Zhengfen Xu, Yunyan Chen, Jing Wang, Wenlie Wu, Lingyun Zhai, Yuanyuan Zhou, Jianguang Zheng, Xinmei Zhang
Summary: This study conducted a multicenter, placebo-controlled, double-blind randomized clinical trial in China to test the effectiveness and safety of mifepristone for adenomyosis treatment. The results showed that mifepristone could be a new option for treating patients with adenomyosis based on its efficacy and acceptable tolerability.
Article
Medicine, General & Internal
Sheldon H. Preskorn, Scott Zeller, Leslie Citrome, Jeffrey Finman, Joseph F. Goldberg, Maurizio Fava, Rishi Kakar, Michael De Vivo, Frank D. Yocca, Robert Risinger
Summary: The study showed that oral sublingual dexmedetomidine significantly reduced agitation in patients with bipolar disorder at 2 hours. Treatment effects were observed as early as 20 minutes after administration, but some patients experienced adverse events.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Chemistry, Medicinal
Vahdad Varzaghani, Masoomeh Sharifi, Reza Hajiaghaee, Sara Bagheri, Saeideh Momtaz, Zahra Tarassoli, Ali Razmi
Summary: This study aimed to evaluate the efficacy and safety of propolis as a complementary therapy for depressive disorder. The results showed that propolis could safely attenuate symptoms of moderate-severe depression, possibly due to its rich content of phenolic acids and flavonoids.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Majid Ramezani, Mahnaz Reisian, Zohreh Sajadi Hezaveh
Summary: This study investigated the effect of synbiotic supplementation on hypothyroid patients through a double-blind, placebo-controlled, randomized clinical trial. The results showed that a 10-week synbiotic supplementation had no significant effect on thyroid stimulating hormone and free thyroxine, but it improved blood pressure and quality of life.
Article
Psychiatry
Kristina M. Deligiannidis, Samantha Meltzer-Brody, Bassem Maximos, E. Quinn Peeper, Marlene Freeman, Robert Lasser, Amy Bullock, Mona Kotecha, Sigui Li, Fiona Forrestal, Nilanjana Rana, Manny Garcia, Bridgette Leclair, James Doherty
Summary: This study investigated the efficacy and safety of Zuranolone, a positive allosteric modulator of GABAA receptors, as an oral treatment for severe postpartum depression. The results demonstrated significant improvements in depressive symptoms and a good tolerability profile for Zuranolone.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Anesthesiology
Anthony Lembo, John M. Kelley, Judy Nee, Sarah Ballou, Johanna Iturrino, Vivian Cheng, Vikram Rangan, Jesse Katon, William Hirsch, Irving Kirsch, Kathryn Hall, Roger B. Davis, Ted J. Kaptchuk
Summary: In the study on irritable bowel syndrome, open-label placebo (OLP) treatment was found to be superior to no-pill control (NPC) and had similar efficacy to double-blind placebo (DBP).
Article
Medicine, General & Internal
Mei Elansary, Caroline J. Kistin, Jocelyn Antonio, Ivys Fernandez-Pastrana, Aviva Lee-Parritz, Howard Cabral, Emily S. Miller, Michael Silverstein
Summary: This randomized clinical trial compared the effectiveness of immediate referral strategy with short-term management of symptoms among pregnant and postpartum persons with screen-detected depression. The findings showed no significant differences in the rate of depressive or anxiety symptom episodes between groups, but there was evidence suggesting improved symptom trajectory following immediate referral. Further research is needed to guide approaches to ensuring adequate follow-up care for peripartum persons with positive depression screen results.
Article
Medicine, General & Internal
Shenghong Zhang, Baili Chen, Bangmao Wang, Hong Chen, Yan Li, Qian Cao, Jie Zhong, Ming-Jium Shieh, Zhihua Ran, Tongyu Tang, Ming Yang, Beibei Xu, Qiang Wang, Yunjie Liu, Lijia Ma, Xiaolin Wang, Nan Zhang, Su Zhang, Wenyu Guo, Liang Huang, Stefan Schreiber, Minhu Chen
Summary: This study aimed to assess the effect of olamkicept as induction therapy in patients with active ulcerative colitis. The study found that biweekly intravenous infusion of 600 mg olamkicept was more likely to result in clinical response at 12 weeks compared with placebo. However, further research is needed to validate its long-term efficacy and safety.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yuki Arakawa, Maho Haseda, Kosuke Inoue, Daisuke Nishioka, Shiho Kino, Daisuke Nishi, Hideki Hashimoto, Naoki Kondo
Summary: This randomized controlled trial in Japan explored the effectiveness of mHealth professional consultation services in preventing postpartum depression. The study found that women in the mHealth group had a lower risk of postpartum depressive symptoms, higher self-efficacy, less loneliness, and fewer perceived barriers to healthcare access compared to the usual care group. These findings suggest that local government-funded mHealth consultation services can remove physical and psychological barriers to healthcare access in real-world settings.
Article
Medicine, General & Internal
Finn Johannsen, Jens Lykkegaard Olesen, Tommy Frisgaard Ohlenschlager, Mathilde Lundgaard-Nielsen, Camilla Kjaer Cullum, Anna Svarre Jakobsen, Michael Skovdal Rathleff, Peter Stig Magnusson, Michael Kjaer
Summary: This study investigated the effect of corticosteroid injection and exercise therapy compared with placebo injection and exercise therapy in patients with Achilles tendinopathy. The results showed that the combination of corticosteroid injection and exercise therapy significantly improved symptoms and function in patients with Achilles tendinopathy. This is important for the treatment of long-standing Achilles tendinopathy.
Article
Medicine, General & Internal
Jason C. Yam, Xiu Juan Zhang, Yuzhou Zhang, Benjamin H. K. Yip, Fangyao Tang, Emily S. Wong, Christine H. T. Bui, Ka Wai Kam, Mandy P. H. Ng, Simon T. Ko, Wilson W. K. Yip, Alvin L. Young, Clement C. Tham, Li Jia Chen, Chi Pui Pang
Summary: The study aimed to evaluate the efficacy of low-concentration atropine eyedrops at 0.05% and 0.01% concentration for delaying the onset of myopia. The results showed that children who used 0.05% atropine eyedrops had a significantly lower incidence of myopia and percentage of participants with fast myopic shift at 2 years, compared to the placebo group. There was no significant difference between the 0.01% atropine group and the placebo group.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Pharmacology & Pharmacy
Yardana Kaufman, Sara Carlini, Kristina M. Deligiannidis
Summary: Postpartum depression is a common condition that can have negative effects on both the mother and the baby. Standard antidepressants have limited evidence for their safety and efficacy, while new drugs may offer better treatment options. This article reviews the efficacy and safety of various drugs in the treatment of postpartum depression.
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jeffrey Wald, Anja Henningsson, Eva Hanze, Ethan Hoffmann, Haihong Li, Helen Colquhoun, Kristina M. Deligiannidis
Summary: This study assessed the pharmacokinetic properties of brexanolone and determined the relative infant dose in breastfeeding mothers. The results showed that the concentration-time profiles of allopregnanolone in breast milk and plasma were similar. The study also found that brexanolone weight-based dosing is appropriate and supports other labeling recommendations.
CLINICAL PHARMACOKINETICS
(2022)
Review
Biochemistry & Molecular Biology
Georgios Schoretsanitis, Kristina M. Deligiannidis, Michael Paulzen, Edoardo Spina, Jose de Leon
Summary: This comprehensive overview examines pharmacokinetic drug-drug interactions between oral contraceptives (OCs) and psychotropic medications. The findings provide recommendations for clinicians and dosage correction factors based on available evidence and package inserts.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Article
Clinical Neurology
Kristina M. Deligiannidis, Thalia Robakis, Sarah C. Homitsky, Erona Ibroci, Bridget King, Sunu Jacob, Diana Coppola, Shane Raines, Konstantinos Alataris
Summary: The study suggests that the Nesos taVNS system may be an effective non-invasive, non-pharmacological treatment for major depressive disorder with peripartum onset. However, further evaluation in larger sham-controlled studies is needed.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Meeting Abstract
Psychology, Developmental
David L. Kaye, Victor M. Fornari, Michael A. Scharf, Wanda Fremont, Rachel Zuckerbrot, Kristina M. Deligiannidis, Breck Borcherding, Carmel A. Foley, James M. Wallace, Sourav Sengupta, Eric R. MacMaster, Nayla M. Khoury, Zoya Popivker, Elizabeth Fitelson, Catherine Monk, Beth A. Smith, Ira Bhatia
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
C. Neill Epperson, David R. Rubinow, Samantha Meltzer-Brody, Kristina M. Deligiannidis, Robert Riesenberg, Andrew D. Krystal, Kemi Bankole, Ming-Yi Huang, Haihong Li, Colville Brown, Stephen J. Kanes, Robert Lasser
Summary: The study demonstrates that Brexanolone is associated with rapid improvement in depressive symptoms and symptoms of anxiety and insomnia compared with placebo in women with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Obstetrics & Gynecology
Sara Carlini, Teresa Lanza di Scalea, Stephanie Trentacoste McNally, Janice Lester, Kristina M. Deligiannidis
Summary: This article provides a clinically focused review of the last twenty years of research on the treatment of premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). The review evaluates 194 studies and finds that selective serotonin reuptake inhibitors (SSRIs) and combined oral contraceptives (COCs) have the highest quality evidence, while gonadotropin releasing hormone (GnRH) agonists and surgical interventions show efficacy for refractory cases. Alternative and complementary medicine treatments such as nutraceuticals, acupuncture, and yoga also show some evidence of efficacy, but the variability in study quality and methods must be considered.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Psychiatry
Sara Carlini, Sandra J. Weiss, Lauren Mordukhaev, Sunu Jacob, Heather A. Flynn, Kristina M. Deligiannidis
Summary: The study found that nearly one-third of women reporting premenstrual symptoms also reported the presence of suicidal ideation, highlighting the importance of premenstrual syndrome as a significant cyclic risk factor.
BIOPSYCHOSOCIAL MEDICINE
(2022)
Meeting Abstract
Obstetrics & Gynecology
Bassem Maximos, Kristina Deligiannidis, Samantha Meltzer-Brody, E. Quinn Peeper, Robert Lasser, Amy Bullock, Mona Kotecha, Sigui Li, Fiona Forrestal, Manny Garcia, Bridgette Leclair, Jim Doherty
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Psychiatry
A. Clayton, A. J. Cutler, K. M. Deligiannidis, R. Lasser, J. Sankoh, J. Doherty, M. Kotecha
EUROPEAN PSYCHIATRY
(2022)
Correction
Psychiatry
K. M. Deligiannidis, S. Meltzer-Brody, H. Gunduz-Bruce
Correction
Psychiatry
K. M. Deligiannidis, S. Meltzer-Brody, H. Gunduz-Bruce
Meeting Abstract
Obstetrics & Gynecology
Anita H. Clayton, Kristina M. Deligiannidis, Mona Kotecha, James Doherty
OBSTETRICS AND GYNECOLOGY
(2022)
Correction
Psychiatry
K. M. Deligiannidis, S. Meltzer-Brody, H. Gunduz-Bruce
Meeting Abstract
Neurosciences
Kristina Deligiannidis, Anita Clayton, Robert Lasser, Colville Brown, Richard Hughes, Nilanjana Rana, Mona Kotecha, James Doherty
BIOLOGICAL PSYCHIATRY
(2022)