Identification of Novel Functional Inhibitors of Acid Sphingomyelinase

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

(2011) Daniel Canals et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants

(2010) Glyn Dawson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cheminformatics approaches to analyze diversity in compound screening libraries

(2010) Lakshmi B Akella et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Prediction of passive blood–brain partitioning: Straightforward and effective classification models based on in silico derived physicochemical descriptors

(2010) Santiago Vilar et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Acid Sphingomyelinase Inhibitors Normalize Pulmonary Ceramide and Inflammation in Cystic Fibrosis

(2009) Katrin Anne Becker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Therapeutic Efficacy and Safety of Amitriptyline in Patients with Cystic Fibrosis

(2009) Joachim Riethmüller et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

The role of ceramide in major depressive disorder

(2009) Johannes Kornhuber et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

PubChem: a public information system for analyzing bioactivities of small molecules

(2009) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

INHIBITION OF CERAMIDE BIOSYNTHESIS AMELIORATES PATHOLOGICAL CONSEQUENCES OF SPINAL CORD INJURY

(2009) Salvatore Cuzzocrea et al.   SHOCK

Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells

(2008) Si Jin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enriched random forests

(2008) D. Amaratunga et al.   BIOINFORMATICS

Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction

(2008) William S Bush et al.   BMC BIOINFORMATICS

Changes in sphingomyelinases, ceramide, Bax, Bcl2, and caspase-3 during and after experimental status epilepticus

(2008) Mohamad A. Mikati et al.   EPILEPSY RESEARCH

Quantitative modeling of selective lysosomal targeting for drug design

(2008) Stefan Trapp et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Predicting blood–brain barrier penetration from molecular weight and number of polar atoms

(2008) Xu-Chun Fu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

(2008) Eric L. Smith et al.   FASEB JOURNAL

Parameterization of an empirical model for the prediction of n-octanol, alkane and cyclohexane/water as well as brain/blood partition coefficients

(2008) Mohamed Zerara et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Size-intensive descriptors

(2008) George D. Purvis   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Ionization-Specific Prediction of Blood–Brain Permeability

(2008) Kiril Lanevskij et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Spinal Ceramide Modulates the Development of Morphine Antinociceptive Tolerance via Peroxynitrite-Mediated Nitroxidative Stress and Neuroimmune Activation

(2008) M. M. Ndengele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High Throughput Lipidomic Profiling of Schizophrenia and Bipolar Disorder Brain Tissue Reveals Alterations of Free Fatty Acids, Phosphatidylcholines, and Ceramides

(2008) Emanuel Schwarz et al.   JOURNAL OF PROTEOME RESEARCH

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Deregulation of sphingolipid metabolism in Alzheimer's disease

(2008) Xingxuan He et al.   NEUROBIOLOGY OF AGING

Acid sphingomyelinase deficiency protects from cisplatin-induced gastrointestinal damage

(2008) A Rebillard et al.   ONCOGENE

QSAR Modeling of the Blood–Brain Barrier Permeability for Diverse Organic Compounds

(2008) Liying Zhang et al.   PHARMACEUTICAL RESEARCH

Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model

(2007) Johannes Kornhuber et al.   JOURNAL OF MEDICINAL CHEMISTRY