Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells

Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies

(2012) Concetta Conticello et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells

(2011) Alysha K. Croker et al.   BREAST CANCER RESEARCH AND TREATMENT

Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

(2011) N C Yip et al.   BRITISH JOURNAL OF CANCER

The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance

(2011) Jan S. Moreb et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aldehyde dehydrogenases and cell proliferation

(2011) G. Muzio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

(2011) Xiao-Qun Ye et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

(2010) C. N. Landen et al.   MOLECULAR CANCER THERAPEUTICS

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

Phase II study of fixed dose rate gemcitabine as radiosensitizer for newly diagnosed glioblastoma multiforme

(2009) Giulio Metro et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

(2009) Xiaoxia Guo et al.   CANCER LETTERS

High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth

(2009) K. Iljin et al.   CLINICAL CANCER RESEARCH

Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells

(2009) Elise Jean et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells

(2008) Jan S Moreb et al.   Molecular Cancer

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL