Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF- B Pathway and Generation of Reactive Oxygen Species

(2010) Y. Jin et al.   CANCER RESEARCH

Synergistic Activity of Sorafenib and Sulforaphane Abolishes Pancreatic Cancer Stem Cell Characteristics

(2010) Vanessa Rausch et al.   CANCER RESEARCH

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Breast Cancer Stem Cells

(2010) Suling Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?

(2010) Malcolm R Alison et al.   JOURNAL OF PATHOLOGY

Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma

(2010) Brian W. Morrison et al.   MELANOMA RESEARCH

Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer

(2010) C. N. Landen et al.   MOLECULAR CANCER THERAPEUTICS

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis

(2010) Paola Marcato et al.   STEM CELLS

Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines

(2009) Bing Xu et al.   CANCER LETTERS

Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines

(2009) Xiaoxia Guo et al.   CANCER LETTERS

High-Throughput Cell-Based Screening of 4910 Known Drugs and Drug-like Small Molecules Identifies Disulfiram as an Inhibitor of Prostate Cancer Cell Growth

(2009) K. Iljin et al.   CLINICAL CANCER RESEARCH

Inhibition of tumor proteasome activity by gold-dithiocarbamato complexes via both redox-dependent and -independent processes

(2009) Xia Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines

(2009) Daiane S. Marques et al.   LEUKEMIA RESEARCH

Suppressing Glioblastoma Stem Cell Function by Aldehyde Dehydrogenase Inhibition with Chloramphenicol or Disulfiram as a New Treatment Adjunct: A Hypothesis

(2009) Richard Kast et al.   Current Stem Cell Research & Therapy

Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

(2008) Anshul Gupte et al.   CANCER TREATMENT REVIEWS

Phase I study of bortezomib with weekly paclitaxel in patients with advanced solid tumours

(2008) S. Cresta et al.   EUROPEAN JOURNAL OF CANCER

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

(2008) Satori A Marchitti et al.   Expert Opinion on Drug Metabolism & Toxicology

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL