Article
Materials Science, Biomaterials
Wei-Nan Zhao, Hongjuan Li, Shiguo Sun, Yongqian Xu
Summary: The nanotherapeutic approach GOx-CuCaP-DSF is designed to overcome challenges in chemodynamic therapy by self-supplying H2O2 and providing low valence metal ions. It enhances the efficiency of CDT through promoting the Cu+-based Fenton reaction and harnessing the therapeutic effect of a chemotherapeutic drug.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Qing-Hua Lan, Chu-Chu Du, Run-Jie Yu, Jiaoyuan Zhai, Yannan Shi, Longfa Kou, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao, Qing Yao
Summary: The study investigated the use of Tf-DSF/CuS nanocomplex for glioma therapy, demonstrating high cytotoxic effect in vitro and effective tumor growth suppression in vivo. The UTMD technique facilitated selective accumulation of the nanocomplex in the tumor, contributing to the successful treatment outcome.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Iftekhar Hassan, Hossam Ebaid, Ibrahim M. Alhazza, Jameel Al-Tamimi, Ahmed M. Rady
Summary: The present study investigated the potential of combining the anticancer drug 5-FU with copper and its chelating agent, disulfiram, in treating hepatocellular carcinoma in rats. The combination treatment showed significant improvement in most parameters, improving histological details and triggering apoptosis in cancer cells to a remarkable extent. Manipulating copper levels greatly enhances the antineoplastic activity of 5-FU and sensitizes cancer cells to the increased efficacy of the drug.
Article
Cell Biology
Meng-ya Geng, Lizhuo Wang, Ying-ying Song, Jing Gu, Xin Hu, Cheng Yuan, Meng Yang, Wen-jun Pei, Yao Zhang, Jia-lin Gao
Summary: The absence of the Sidt2 gene results in impaired lysosomal function and a decreased number of acidic lysosomes, leading to formation and degradation disorders of autophagolysosomes. Sidt2 plays a crucial role in maintaining the normal function of lysosomes and the physiological stability of the kidneys.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Yufeng Wang, David L. Drum, Ruochuan Sun, Yida Zhang, Feng Chen, Fengfei Sun, Emre Dal, Ling Yu, Jingyu Jia, Shahrzad Arya, Lin Jia, Song Fan, Steven J. Isakoff, Allison M. Kehlmann, Gianpietro Dotti, Fubao Liu, Hui Zheng, Cristina R. Ferrone, Alphonse G. Taghian, Albert B. DeLeo, Marco Ventin, Giulia Cattaneo, Yongxiang Li, Youssef Jounaidi, Peigen Huang, Cristina Maccalli, Hanyu Zhang, Cheng Wang, Jibing Yang, Genevieve M. Boland, Ruslan I. Sadreyev, LaiPing Wong, Soldano Ferrone, Xinhui Wang
Summary: This study demonstrates a non-genetic approach to improve the efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors by reprogramming CAR T cells with stressed target cancer cells, resulting in the acquisition of memory-like characteristics and prolonged anti-tumor response in preclinical models.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy, Douglas W. Sborov, Paul J. Shami
Summary: This study aimed to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced solid tumors and liver involvement. Some toxicities were observed in the treatment group, but overall tolerability was good, with an increase in S-glutathionylation of serum proteins following treatment.
Article
Chemistry, Multidisciplinary
Zeqian Huang, Yong Luo, Tao Zhang, Yaqing Ding, Meixu Chen, Jie Chen, Qiuxing Liu, Yanjuan Huang, Chunshun Zhao
Summary: Selective activation of prodrugs is important for reducing the side effects of disease treatment. In this study, a metal-carrying prochelator concept was proposed, which can co-carry a metal ion and chelator within a small-molecule compound and synthesize a bioactive metal complex for targeted therapy. A H2O2-responsive small-molecule prochelator, DPBD, was designed and showed potent antitumor efficacy with low systemic toxicity by releasing chelator DTC and chelating Cu2+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Sheila S. Fontes, Mateus L. Nogueira, Rosane B. Dias, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Marcos A. Vannier-Santos, Daniel P. Bezerra
Summary: This study investigated the combination of curcumin and disulfiram in the treatment of melanoma and found synergistic anti-tumor effects. The combination promoted apoptosis and DNA fragmentation in melanoma cells and increased oxidative stress. In animal experiments, the combination therapy inhibited tumor growth.
Article
Oncology
Marwa M. Abu-Serie, Marwa Eltarahony
Summary: A novel nanocomplex of DS-CuO NPs was prepared, showing high stability and potent selective anticancer activity against human breast, lung, and liver cancer cells with low inhibitory concentration. This nanocomplex exhibited better anticancer effect and cellular uptake, as well as prooxidant effect-mediated apoptosis and anti-metastatic potential. These findings suggest that the novel nanocomplex may improve the therapeutic index of the conventional DS-Cu complex and warrant further investigation for future clinical applications.
CANCER NANOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haixian Zhang, Feifei Song, Caihong Dong, Luodan Yu, Cai Chang, Yu Chen
Summary: This study proposed a therapeutic construction with high biosafety and efficiency for synergistic tumor-activated and photothermal-augmented chemotherapy in breast tumor eradication both in vitro and in vivo, achieving remarkable results in tumor elimination.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vinodh Kannappan, Misha Ali, Benjamin Small, Gowtham Rajendran, Salena Elzhenni, Hamza Taj, Weiguang Wang, Q. Ping Dou
Summary: Copper plays a key role in cancer progression and copper-based complexes are being investigated as novel anticancer drugs. The combination of DSF with copper has shown great anticancer potential, but DSF has proven unsuccessful in clinical trials, likely due to poor stability of the currently used oral version of DSF.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Environmental Sciences
Wenlan Yu, Jianzhao Liao, Fan Yang, Hui Zhang, Xiaoyue Chang, Yanyang Yang, Rana Muhammad Bilal, Guimei Wei, Wenqing Liang, Jianying Guo, Zhaoxin Tang
Summary: High concentrations of copper exposure can lead to oxidative stress liver injury, while appropriate dietary copper can promote mitophagy and alleviate oxidative stress. Excess copper accumulation, on the other hand, can cause liver damage and inhibit mitophagy pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Han-Xiao Tang, Jian-Ting Zhang, Chen-Guang Liu, Shi-Bin Wang, Xiao-Ke Zheng, Ai-Zheng Chen
Summary: In this study, a simple and efficient strategy was developed for the controllable loading of hydrophobic DSF into Cu2+-doped mesoporous silica nanoparticles (Cu-MSN) using supercritical CO2 technology. The DSF-loaded Cu-MSN exhibited high anticancer activity in vitro and in vivo, indicating its potential in cancer therapy.
JOURNAL OF CO2 UTILIZATION
(2023)
Article
Engineering, Biomedical
Yao Lu, Qingqing Pan, Wenxia Gao, Yuji Pu, Kui Luo, Bin He, Zhongwei Gu
Summary: Disulfiram (DSF) has been used as an alcoholism drug for 70 years and has recently gained attention for its anticancer activity. However, the oral delivery of DSF in clinical settings has not yielded satisfactory outcomes, calling for a deeper understanding of its mechanisms and limitations. This review provides a critical summary of the molecular biological anticancer mechanisms of DSF/Cu2+ and explains the challenges of oral DSF delivery in clinical oncology. It also highlights recent advances in DSF/Cu2+ delivery strategies and emerging treatment regimens for cancer therapy.
Article
Infectious Diseases
Claire N. Shanholtzer, Cameron Rice, Katherine Watson, Hannah Carreon, Timothy E. Long
Summary: This study evaluated the impact of copper on the antifungal activity of disulfiram against fluconazole-resistant Candida species. The results showed that copper addition enhanced the inhibitory effects of disulfiram on Candida cultures, but it also antagonized the fungicidal activity of disulfiram.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)