The Role and Regulatory Mechanism of Transcription Factor EB in Health and Diseases

The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis

(2021) Alessia Oppezzo et al.   Cell and Bioscience

Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation

(2020) Javier E. Irazoqui   TRENDS IN IMMUNOLOGY

Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte

(2020) Purvi C. Trivedi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-dependent TFEB Signaling Pathway

(2020) Yan You et al.   CIRCULATION RESEARCH

Emerging role of transcription factor EB in mitochondrial quality control

(2020) Shujun Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Xenophagy in innate immunity: A battle between host and pathogen

(2020) Zhenhui Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Lysosomal quality control of cell fate: a novel therapeutic target for human diseases

(2020) Sheng-yu Zhu et al.   Cell Death & Disease

Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2

(2020) Jinjian Sun et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization

(2019) Yang Xu et al.   Autophagy

Inhibition of TFEB oligomerization by co-treatment of melatonin with vorinostat promotes the therapeutic sensitivity in glioblastoma and glioma stem cells

(2019) Gi-Jun Sung et al.   JOURNAL OF PINEAL RESEARCH

The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

(2019) Leeanna El-Houjeiri et al.   Cell Reports

Impaired TFEB-Mediated Lysosomal Biogenesis Promotes the Development of Pancreatitis in Mice and Is Associated with Human Pancreatitis

(2019) Shaogui Wang et al.   Autophagy

Overexpression of transcription factor EB regulates mitochondrial autophagy to protect lipopolysaccharide-induced acute lung injury

(2019) Wei Liu et al.   CHINESE MEDICAL JOURNAL

Ligand-activated progesterone receptor B activates transcription factor EB to promote autophagy in human breast cancer cells

(2019) Sijie Tan et al.   EXPERIMENTAL CELL RESEARCH

SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL‐treated human vascular smooth muscle cells

(2019) Huifeng Pi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer

(2019) Xingguo Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB

(2019) Xi Zhou et al.   Nutrition & Metabolism

The transcription factor MITF in RPE function and dysfunction

(2019) Xiaoyin Ma et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mitochondria and Inflammation: Cell Death Heats Up

(2019) Esmee Vringer et al.   Frontiers in Cell and Developmental Biology

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

Mitochondria as central hub of the immune system

(2019) Cristiane Naffah de Souza Breda et al.   Redox Biology

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

(2019) Chunyan Li et al.   Frontiers in Cell and Developmental Biology

Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

(2019) Ziyan Zhang et al.   Autophagy

3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE 3 and TFEB

(2019) Guo Chen et al.   EMBO Molecular Medicine

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

(2019) Yusha Wang et al.   EMBO REPORTS

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast cancer cells

(2019) Logan Slade et al.   BIOCHEMICAL JOURNAL

Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle

(2019) W.F. Theeuwes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner

(2018) Avigail T. Erlich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ligand-dependent transcriptional induction of lethal autophagy: A new perspective for cancer treatment

(2018) Sandrine Silvente-Poirot et al.   Autophagy

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis

(2018) Trent D. Evans et al.   Autophagy

STAT3 contributes to lysosomal-mediated cell death in a novel derivative of riccardin D-treated breast cancer cells in association with TFEB

(2018) Lin Li et al.   BIOCHEMICAL PHARMACOLOGY

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

(2018) Amin Ardestani et al.   Cell Metabolism

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

(2018) Constanza J. Cortes et al.   NEUROBIOLOGY OF DISEASE

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

(2018) Cynthia L. Hsu et al.   Nature Communications

TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins

(2018) Samrat T. Kundu et al.   Nature Communications

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

(2018) Melissa J. Silvestrini et al.   Cell Reports

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy

(2018) Israel C. Nnah et al.   Autophagy

MPB, a novel berberine derivative, enhances lysosomal and bactericidal properties via TGF-β–activated kinase 1-dependent activating the transcription factor EB

(2018) Xiaojia Liu et al.   FASEB JOURNAL

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB

(2018) Ruizhi He et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TFEB, a potential therapeutic target for osteoarthritis via autophagy regulation

(2018) Gang Zheng et al.   Cell Death & Disease

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Autophagic flux response and glioblastoma sensitivity to radiation

(2018) G. Mitrakas Achilleas et al.   Cancer Biology & Medicine

MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress

(2018) Deniz Gulfem Ozturk et al.   Autophagy

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

(2018) Hyo Jeong Kim et al.   Cell Death & Disease

Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A

(2017) Jinzhong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism

(2017) Yi Sak Kim et al.   JOURNAL OF IMMUNOLOGY

The MiTF/TFE Family of Transcription Factors: Master Regulators of Organelle Signaling, Metabolism, and Stress Adaptation

(2017) Logan Slade et al.   MOLECULAR CANCER RESEARCH

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

(2017) Rose Willett et al.   Nature Communications

Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo

(2017) Tatsuro Murano et al.   Scientific Reports

Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells

(2017) Hisa Hui Ling Tseng et al.   Frontiers in Immunology

Autophagy: A Potential Therapeutic Target for Reversing Sepsis-Induced Immunosuppression

(2017) Chao Ren et al.   Frontiers in Immunology

Transcriptional factor EB regulates macrophage polarization in the tumor microenvironment

(2017) Liang Fang et al.   OncoImmunology

TFEB-amplified Renal Cell Carcinomas

(2016) Pedram Argani et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure

(2016) Yohan Santin et al.   ANTIOXIDANTS & REDOX SIGNALING

DrosophilaMitf regulates the V-ATPase and the lysosomal-autophagic pathway

(2016) Valentina Bouché et al.   Autophagy

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression

(2016) Alicia M. Blessing et al.   Autophagy

Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B

(2016) Si Ming Man et al.   Autophagy

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages

(2016) Nunzia Pastore et al.   Autophagy

tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis

(2016) C. B. Mahony et al.   BLOOD

Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy

(2016) Ilias V Karagounis et al.   BRITISH JOURNAL OF CANCER

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB

(2016) Matthew A. Gray et al.   CURRENT BIOLOGY

TFEB and TFE3 are novel components of the integrated stress response

(2016) J. A. Martina et al.   EMBO JOURNAL

FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells

(2016) Dongyoung Kim et al.   JOURNAL OF PROTEOME RESEARCH

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice

(2016) Fang Li et al.   Oxidative Medicine and Cellular Longevity

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

(2016) Jintao Bao et al.   Protein & Cell

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

(2015) Davor Ivankovic et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of the Transcription Factor EB-PGC1α Axis by Beclin-1 Controls Mitochondrial Quality and Cardiomyocyte Death under Stress

(2015) Xiucui Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy

(2014) Genki Tohnai et al.   HUMAN MOLECULAR GENETICS

Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes

(2014) Orane Visvikis et al.   IMMUNITY

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA

(2014) Constanza J Cortes et al.   NATURE NEUROSCIENCE

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

GCN5-like Protein 1 (GCN5L1) Controls Mitochondrial Content through Coordinated Regulation of Mitochondrial Biogenesis and Mitophagy

(2013) Iain Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice

(2012) Hitoshi Iwasaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Intracellular NAD+depletion induces autophagic death in multiple myeloma cells

(2012) Michele Cea et al.   Autophagy

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF

(2012) V. Pogenberg et al.   GENES & DEVELOPMENT

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

(2011) W van Veelen et al.   ONCOGENE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Identification of a Lysosomal Pathway That Modulates Glucocorticoid Signaling and the Inflammatory Response

(2011) Y. He et al.   Science Signaling

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE