Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes

Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes

(2018) Souvarish Sarkar et al.   NEUROTOXICOLOGY

Autophagy plays a protective role in Mn-induced toxicity in PC12 cells

(2018) Qian Zhou et al.   TOXICOLOGY

A TFEB nuclear export signal integrates amino acid supply and glucose availability

(2018) Linxin Li et al.   Nature Communications

Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy

(2018) C. M. Drion et al.   Journal of Neuroinflammation

The role S-nitrosylation in manganese-induced autophagy dysregulation in SH-SY5Y cells

(2017) Zhuo Ma et al.   ENVIRONMENTAL TOXICOLOGY

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Autophagy blockade and lysosomal membrane permeabilization contribute to lead-induced nephrotoxicity in primary rat proximal tubular cells

(2017) Xiang-Bin Song et al.   Cell Death & Disease

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

(2017) Fei Gao et al.   Frontiers in Neurology

Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons

(2017) Matthew Redmann et al.   Redox Biology

Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity

(2017) Huifeng Pi et al.   Scientific Reports

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells

(2016) Min Li et al.   JOURNAL OF PINEAL RESEARCH

Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux

(2016) Akihiko Kimura et al.   TOXICOLOGY

PINK1/Parkin-mediated mitophagy play a protective role in manganese induced apoptosis in SH-SY5Y cells

(2016) Hong-Tao Zhang et al.   TOXICOLOGY IN VITRO

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

(2016) Kavya Reddy et al.   Cell Reports

Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay

(2015) Eirini Lionaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions

(2015) RM Gorojod et al.   FREE RADICAL BIOLOGY AND MEDICINE

Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells

(2015) Ola Awad et al.   HUMAN MOLECULAR GENETICS

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

(2015) Michael Fritz et al.   JOURNAL OF CLINICAL INVESTIGATION

Manganese homeostasis in the nervous system

(2015) Pan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission

(2015) Safa Bouabid et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin

(2015) A. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach

(2015) Jihoon Nah et al.   MOLECULES AND CELLS

Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity

(2015) Pratap Karki et al.   NEUROCHEMISTRY INTERNATIONAL

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

(2015) Marta Martinez-Vicente   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of Astrocyte Mitochondria in Differential Regional Susceptibility to Environmental Neurotoxicants: Tools for Understanding Neurodegeneration

(2015) Laura L. Kubik et al.   TOXICOLOGICAL SCIENCES

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

(2015) Gunnar Kwakye et al.   International Journal of Environmental Research and Public Health

Role of autophagy in methylmercury-induced neurotoxicity in rat primary astrocytes

(2014) Fang Yuntao et al.   ARCHIVES OF TOXICOLOGY

Evaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles

(2014) Agnieszka Pierzyńska-Mach et al.   CYTOMETRY PART A

Neurobehavioral Function in School-Age Children Exposed to Manganese in Drinking Water

(2014) Youssef Oulhote et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Considerations on manganese (Mn) treatments for in vitro studies

(2014) Aaron B. Bowman et al.   NEUROTOXICOLOGY

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

Manganese neurotoxicity and the role of reactive oxygen species

(2013) Ebany J. Martinez-Finley et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Manganese induces mitochondrial dynamics impairment and apoptotic cell death: A study in human Gli36 cells

(2013) Agustina Alaimo et al.   NEUROSCIENCE LETTERS

The Role of Autophagy Dysregulation in Manganese-Induced Dopaminergic Neurodegeneration

(2013) Jianbin Zhang et al.   NEUROTOXICITY RESEARCH

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal Membrane Proteins and Their Central Role in Physiology

(2013) Michael Schwake et al.   TRAFFIC

Role of astrocytes in manganese mediated neurotoxicity

(2013) Marta Sidoryk-Wegrzynowicz et al.   BMC Pharmacology & Toxicology

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Integration of cellular bioenergetics with mitochondrial quality control and autophagy

(2012) Bradford G. Hill et al.   BIOLOGICAL CHEMISTRY

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

(2012) Marcelo Farina et al.   NEUROCHEMISTRY INTERNATIONAL

Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

(2012) Jennifer L. Madison et al.   PLoS One

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Mitochondria removal by autophagy

(2011) Ke Wang et al.   Autophagy

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

(2011) Carmine Settembre et al.   Autophagy

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

Manganese exposure from drinking water and children's academic achievement

(2011) Khalid Khan et al.   NEUROTOXICOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Intellectual Impairment in School-Age Children Exposed to Manganese from Drinking Water

(2010) Maryse F. Bouchard et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In search of an “autophagomometer”

(2009) David C. Rubinsztein et al.   Autophagy

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

(2009) Anurag Kumar Singh et al.   JOURNAL OF CLINICAL INVESTIGATION

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia

(2009) Gregg D. Stanwood et al.   JOURNAL OF NEUROCHEMISTRY

Manganese and its Role in Parkinson’s Disease: From Transport to Neuropathology

(2009) Michael Aschner et al.   NEUROMOLECULAR MEDICINE

Oxidative damage and neurodegeneration in manganese-induced neurotoxicity

(2009) Dejan Milatovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

(2008) Zhaoobao Yin et al.   BRAIN RESEARCH

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats

(2007) M. Morello et al.   NEUROTOXICOLOGY