NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer

Temozolomide–perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer

(2018) Xingguo Song et al.   Cell Death & Disease

Targeting cancer cell mitochondria as a therapeutic approach: recent updates

(2017) Qingbin Cui et al.   Future Medicinal Chemistry

Effects of endoplasmic reticulum stress on the autophagy, apoptosis, and chemotherapy resistance of human breast cancer cells by regulating the PI3K/AKT/mTOR signaling pathway

(2017) Jia-Teng Zhong et al.   TUMOR BIOLOGY

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases

(2016) Marco Sardiello   Annals of the New York Academy of Sciences

Mitochondrial dynamics altered by oxidative stress in cancer

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Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer

(2016) Xingguo Song et al.   Scientific Reports

Does mitochondrial fusion require transmembrane potential?

(2015) I. E. Karavaeva et al.   BIOCHEMISTRY-MOSCOW

When cytoprotective autophagy isn’t… and even when it is

(2014) David A Gewirtz   Autophagy

NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas

(2014) H.-Y. Cho et al.   MOLECULAR CANCER THERAPEUTICS

A Novel Temozolomide-Perillyl Alcohol Conjugate Exhibits Superior Activity against Breast Cancer Cells In Vitro and Intracranial Triple-Negative Tumor Growth In Vivo

(2014) T. C. Chen et al.   MOLECULAR CANCER THERAPEUTICS

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Therapeutic strategies in epithelial ovarian cancer

(2012) Ayako Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas

(2012) H.-Y. Cho et al.   MOLECULAR CANCER THERAPEUTICS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Ovarian Cancer Development and Metastasis

(2010) Ernst Lengyel   AMERICAN JOURNAL OF PATHOLOGY

Oxidative Stress Stimulates Autophagic Flux During Ischemia/Reperfusion

(2010) Nirmala Hariharan et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of CHK2 in cancer development

(2008) Rosario Perona et al.   Clinical & Translational Oncology

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls

(2008)   LANCET