Lysosomal quality control of cell fate: a novel therapeutic target for human diseases

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

(2020) Ren-Qi Yao et al.   Autophagy

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Molecular Mechanisms of Lysosome and Nucleus Communication

(2020) Qian Zhao et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

(2019) Xiucui Ma et al.   Journal of the American Heart Association

Update on the Genetics of Spastic Paraplegias

(2019) Maxime Boutry et al.   Current Neurology and Neuroscience Reports

Cilostazol protects against myocardial ischemia and reperfusion injury by activating transcription factor EB (TFEB)

(2019) Jiangjin Li et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation

(2019) Sabrina Sofia Burgener et al.   Cell Reports

The Lysosome Signaling Platform: Adapting With the Times

(2019) Subothan Inpanathan et al.   Frontiers in Cell and Developmental Biology

Synergistic anti-breast cancer effect of pulsatilla saponin D and camptothecin through interrupting autophagic–lysosomal function and promoting p62-mediated ubiquitinated protein aggregation

(2019) Kai Wang et al.   CARCINOGENESIS

Repair or Lysophagy: Dealing with Damaged Lysosomes

(2019) Chrisovalantis Papadopoulos et al.   JOURNAL OF MOLECULAR BIOLOGY

Resolution of inflammation: from basic concepts to clinical application

(2019) Markus F. Neurath   Seminars in Immunopathology

Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity

(2019) Marzia Savini et al.   TRENDS IN CELL BIOLOGY

Ferroptosis is a lysosomal cell death process

(2018) Huan Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lysosomal acid lipase and lipid metabolism

(2018) Hanrui Zhang   CURRENT OPINION IN LIPIDOLOGY

Cargo recognition and degradation by selective autophagy

(2018) Damián Gatica et al.   NATURE CELL BIOLOGY

Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

(2018) Cong-Lin Liu et al.   Nature Reviews Cardiology

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis

(2018) Shuo Liu et al.   Cell Death & Disease

Cathepsin B: Active site mapping with peptidic substrates and inhibitors

(2018) Janina Schmitz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Lysosome: The metabolic signaling hub

(2018) Dudley W. Lamming et al.   TRAFFIC

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Review of Gaucher Disease Pathophysiology, Clinical Presentation and Treatments

(2017) Jérôme Stirnemann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mastocarcinoma therapy synergistically promoted by lysosome dependent apoptosis specifically evoked by 5-Fu@nanogel system with passive targeting and pH activatable dual function

(2017) Xiandi Zhu et al.   JOURNAL OF CONTROLLED RELEASE

SZT2 dictates GATOR control of mTORC1 signalling

(2017) Min Peng et al.   NATURE

Ubiquitination of exposed glycoproteins by SCFFBXO27directs damaged lysosomes for autophagy

(2017) Yukiko Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blocking Liver Autophagy Accelerates Apoptosis and Mitochondrial Injury in Hepatocytes and Reduces Time to Mortality in a Murine Sepsis Model

(2017) Takehiko Oami et al.   SHOCK

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Emerging Roles for the Lysosome in Lipid Metabolism

(2017) Ashley M. Thelen et al.   TRENDS IN CELL BIOLOGY

Knockout of Eva1a leads to rapid development of heart failure by impairing autophagy

(2017) Shu Zhang et al.   Cell Death & Disease

Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1

(2017) Tianlong Zhang et al.   Nature Communications

Phagocytosis: A Fundamental Process in Immunity

(2017) Carlos Rosales et al.   Biomed Research International

Diversity and Versatility of Phagocytosis: Roles in Innate Immunity, Tissue Remodeling, and Homeostasis

(2017) Justin J. Lim et al.   Frontiers in Cellular and Infection Microbiology

Control of Phagocytosis by Microbial Pathogens

(2017) Eileen Uribe-Querol et al.   Frontiers in Immunology

Autophagy: A Potential Therapeutic Target for Reversing Sepsis-Induced Immunosuppression

(2017) Chao Ren et al.   Frontiers in Immunology

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Lysosomal cell death mechanisms in aging

(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Autophagy in sepsis: Degradation into exhaustion?

(2016) Jeffery Ho et al.   Autophagy

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

An essential role for functional lysosomes in ferroptosis of cancer cells

(2016) S. Torii et al.   BIOCHEMICAL JOURNAL

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Release of Cathepsin B in Cytosol Causes Cell Death in Acute Pancreatitis

(2016) Rupjyoti Talukdar et al.   GASTROENTEROLOGY

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

Regulation of lysosomal ion homeostasis by channels and transporters

(2016) Jian Xiong et al.   Science China-Life Sciences

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease

(2016) Rituraj Pal et al.   Scientific Reports

Danon disease: a phenotypic expression of LAMP-2 deficiency

(2015) Yukari Endo et al.   ACTA NEUROPATHOLOGICA

Targeting the lysosome in cancer

(2015) Shengfu Piao et al.   Annals of the New York Academy of Sciences

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

(2015) Ana Serrano-Puebla et al.   Annals of the New York Academy of Sciences

Autophagy in Vascular Disease

(2015) G. R. Y. De Meyer et al.   CIRCULATION RESEARCH

The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms

(2015) Jin-Sung Park et al.   MOVEMENT DISORDERS

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

The role of lysosome in cell death regulation

(2015) Feifei Yu et al.   TUMOR BIOLOGY

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Regulated lysosomal exocytosis mediates cancer progression

(2015) E. Machado et al.   Science Advances

Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae

(2014) Roy Emanuel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

(2014) Jordi Bové et al.   Autophagy

Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway

(2014) Min Xu et al.   GLIA

Structure of Transmembrane Domain of Lysosome-associated Membrane Protein Type 2a (LAMP-2A) Reveals Key Features for Substrate Specificity in Chaperone-mediated Autophagy

(2014) Ashok K. Rout et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal membrane permeabilization in cell death: Concepts and challenges

(2014) Urška Repnik et al.   MITOCHONDRION

Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP

(2014) E.E. Coffey et al.   NEUROSCIENCE

mTORC1 signaling controls multiple steps in ribosome biogenesis

(2014) Valentina Iadevaia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tacrine induces apoptosis through lysosome- and mitochondria-dependent pathway in HepG2 cells

(2014) Chunpeng Gao et al.   TOXICOLOGY IN VITRO

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Poly IC Triggers a Cathepsin D- and IPS-1-Dependent Pathway to Enhance Cytokine Production and Mediate Dendritic Cell Necroptosis

(2013) Jian Zou et al.   IMMUNITY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression

(2013) F Bengsch et al.   ONCOGENE

Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells

(2013) Chunpeng Gao et al.   PHYTOMEDICINE

Distinct effects of methamphetamine on autophagy–lysosome and ubiquitin–proteasome systems in HL-1 cultured mouse atrial cardiomyocytes

(2013) Izumi Funakoshi-Hirose et al.   TOXICOLOGY

The lysosome: from waste bag to potential therapeutic target

(2013) Hanna Appelqvist et al.   Journal of Molecular Cell Biology

Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death

(2012) Xiucui Ma et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

(2012) N. P. Withana et al.   CANCER RESEARCH

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Ubiquitination and selective autophagy

(2012) S Shaid et al.   CELL DEATH AND DIFFERENTIATION

Lysosomal pathways to cell death and their therapeutic applications

(2012) Maruša Hafner Česen et al.   EXPERIMENTAL CELL RESEARCH

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

How nascent phagosomes mature to become phagolysosomes

(2012) Gregory D. Fairn et al.   TRENDS IN IMMUNOLOGY

Biogenesis and Cargo Selectivity of Autophagosomes

(2011) Hilla Weidberg et al.   Annual Review of Biochemistry

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional characterization of (pro)renin receptor in association with V-ATPase

(2011) Kenichiro Kinouchi   Frontiers in Bioscience-Landmark

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

(2010) Nikolaj H.T. Petersen et al.   CELL CYCLE

Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology

(2010) Thomas Kirkegaard et al.   NATURE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

(2010) L Sevenich et al.   ONCOGENE

The delivery of endocytosed cargo to lysosomes: Figure 1

(2009) J. Paul Luzio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Inflammation

(2008) Ursula Weiss   NATURE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY