Chromosome Organization in Early Meiotic Prophase

Loop extrusion as a mechanism for formation of DNA damage repair foci

(2021) Coline Arnould et al.   NATURE

Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice

(2021) Ihsan Dereli et al.   NUCLEIC ACIDS RESEARCH

Interplay between Pds5 and Rec8 in regulating chromosome axis length and crossover frequency

(2021) Meihui Song et al.   Science Advances

Mechanism and Control of Meiotic DNA Double-Strand Break Formation in S. cerevisiae

(2021) Vikash Kumar Yadav et al.   Frontiers in Cell and Developmental Biology

Regulation of Cohesin-Mediated Chromosome Folding by Eco1 and Other Partners

(2020) Lise Dauban et al.   MOLECULAR CELL

Interacting genomic landscapes of REC8-cohesin, chromatin and meiotic recombination in Arabidopsis thaliana

(2020) Christophe Lambing et al.   PLANT CELL

PDS 5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis

(2020) Alberto Viera et al.   EMBO REPORTS

Topoisomerases Modulate the Timing of Meiotic DNA Breakage and Chromosome Morphogenesis in Saccharomyces cerevisiae

(2020) Jonna Heldrich et al.   GENETICS

Wapl releases Scc1-cohesin and regulates chromosome structure and segregation in mouse oocytes

(2020) Mariana C.C. Silva et al.   JOURNAL OF CELL BIOLOGY

Multilayered mechanisms ensure that short chromosomes recombine in meiosis

(2020) Hajime Murakami et al.   NATURE

Ensuring meiotic DNA break formation in the mouse pseudoautosomal region

(2020) Laurent Acquaviva et al.   NATURE

Quantitative cytogenetics reveals molecular stoichiometry and longitudinal organization of meiotic chromosome axes and loops

(2020) Alexander Woglar et al.   PLOS BIOLOGY

Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase

(2020) Yasuhiro Fujiwara et al.   PLoS Genetics

CTCF sites display cell cycle–dependent dynamics in factor binding and nucleosome positioning

(2019) Marlies E. Oomen et al.   GENOME RESEARCH

A conserved filamentous assembly underlies the structure of the meiotic chromosome axis

(2019) Alan M V West et al.   eLife

Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development

(2019) Kris G. Alavattam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase

(2019) Lucas Patel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reprogramming of Meiotic Chromatin Architecture during Spermatogenesis

(2019) Yao Wang et al.   MOLECULAR CELL

Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes

(2019) Tanmoy Bhattacharyya et al.   CURRENT BIOLOGY

Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes

(2019) Frantzeskos Papanikos et al.   MOLECULAR CELL

Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis

(2019) Covadonga Vara et al.   Cell Reports

Conserved HORMA domain-containing protein Hop1 stabilizes interaction between proteins of meiotic DNA break hotspots and chromosome axis

(2019) Ryo Kariyazono et al.   NUCLEIC ACIDS RESEARCH

Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy

(2019) Huizhong Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA loop extrusion by human cohesin

(2019) Iain F. Davidson et al.   SCIENCE

Human cohesin compacts DNA by loop extrusion

(2019) Yoori Kim et al.   SCIENCE

Principles of meiotic chromosome assembly revealed in S. cerevisiae

(2019) Stephanie A. Schalbetter et al.   Nature Communications

Molecular architecture of the SYCP3 fibre and its interaction with DNA

(2019) Daniel Bollschweiler et al.   Open Biology

Organization of Chromosomal DNA by SMC Complexes

(2019) Stanislau Yatskevich et al.   Annual Review of Genetics

Chromosome-associated RNA–protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe

(2019) Da-Qiao Ding et al.   Nature Communications

SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage

(2018) Uddipta Biswas et al.   CURRENT BIOLOGY

Characterizing meiotic chromosomes' structure and pairing using a designer sequence optimized for Hi‐C

(2018) Héloïse Muller et al.   Molecular Systems Biology

A pathway for mitotic chromosome formation

(2018) Johan H. Gibcus et al.   SCIENCE

ATR is a multifunctional regulator of male mouse meiosis

(2018) Alexander Widger et al.   Nature Communications

The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes

(2018) Céline Adam et al.   PLoS Genetics

Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers

(2018) Mridula Nambiar et al.   MOLECULAR CELL

The cohesin complex in mammalian meiosis

(2018) Kei-ichiro Ishiguro   GENES TO CELLS

Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2

(2017) Alan M V West et al.   NUCLEIC ACIDS RESEARCH

Superresolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intactCaenorhabditis eleganstissue

(2017) Simone Köhler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex

(2017) Jianrong Feng et al.   Protein & Cell

Single-molecule observation of DNA compaction by meiotic protein SYCP3

(2017) Johanna L Syrjänen et al.   eLife

The synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors

(2017) Ofer Rog et al.   eLife

Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation

(2016) Mercedes R. Gyuricza et al.   CURRENT BIOLOGY

Meiosis: Cohesins Are Not Just for Sisters Any More

(2016) Cori K. Cahoon et al.   CURRENT BIOLOGY

High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation

(2016) Ana Agostinho et al.   EMBO REPORTS

Sororin loads to the synaptonemal complex central region independently of meiotic cohesin complexes

(2016) Rocío Gómez et al.   EMBO REPORTS

Meiotic cohesin subunits RAD21L and REC8 are positioned at distinct regions between lateral elements and transverse filaments in the synaptonemal complex of mouse spermatocytes

(2016) Mei RONG et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Structural Basis and IP 6 Requirement for Pds5-Dependent Cohesin Dynamics

(2016) Zhuqing Ouyang et al.   MOLECULAR CELL

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice

(2016) Marcello Stanzione et al.   NATURE CELL BIOLOGY

Organization and function of the 3D genome

(2016) Boyan Bonev et al.   NATURE REVIEWS GENETICS

Formation of Chromosomal Domains by Loop Extrusion

(2016) Geoffrey Fudenberg et al.   Cell Reports

Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis

(2016) Uddipta Biswas et al.   PLoS Genetics

Compaction and segregation of sister chromatids via active loop extrusion

(2016) Anton Goloborodko et al.   eLife

Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe

(2015) Da-Qiao Ding et al.   CHROMOSOMA

Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination by Assembling the Meiotic Chromosome Axis

(2015) Takeshi Sakuno et al.   DEVELOPMENTAL CELL

The multifaceted roles of the HORMA domain in cellular signaling

(2015) Scott C. Rosenberg et al.   JOURNAL OF CELL BIOLOGY

MEI4 - a central player in the regulation of meiotic DNA double-strand break formation in the mouse

(2015) R. Kumar et al.   JOURNAL OF CELL SCIENCE

Ycs4 is Required for Efficient Double-Strand Break Formation and Homologous Recombination During Meiosis

(2015) Soogil Hong et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

(2015) Valerie Garcia et al.   NATURE

Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution

(2015) Katharina Schücker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombination, Pairing, and Synapsis of Homologs during Meiosis

(2015) Denise Zickler et al.   Cold Spring Harbor Perspectives in Biology

Meiotic Recombination: The Essence of Heredity

(2015) Neil Hunter   Cold Spring Harbor Perspectives in Biology

Transcription dynamically patterns the meiotic chromosome-axis interface

(2015) Xiaoji Sun et al.   eLife

Self-Organization of Meiotic Recombination Initiation: General Principles and Molecular Pathways

(2014) Scott Keeney et al.   Annual Review of Genetics

The Chromosomal Courtship Dance—homolog pairing in early meiosis

(2014) Michael Klutstein et al.   CURRENT OPINION IN CELL BIOLOGY

The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins

(2014) Yumi Kim et al.   DEVELOPMENTAL CELL

Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion

(2014) T. Winters et al.   EMBO JOURNAL

STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis

(2014) T. Fukuda et al.   EMBO JOURNAL

Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes

(2014) K.-i. Ishiguro et al.   GENES & DEVELOPMENT

Meiotic recombination cold spots in chromosomal cohesion sites

(2014) Masaru Ito et al.   GENES TO CELLS

STAG3 is a strong candidate gene for male infertility

(2014) Elena Llano et al.   HUMAN MOLECULAR GENETICS

Topoisomerase II mediates meiotic crossover interference

(2014) Liangran Zhang et al.   NATURE

The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis

(2014) Hiroki Shibuya et al.   NATURE CELL BIOLOGY

Mutant Cohesin in Premature Ovarian Failure

(2014) Sandrine Caburet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes

(2014) Jessica Hopkins et al.   PLoS Genetics

Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes

(2014) Aaron F Severson et al.   eLife

A molecular model for the role of SYCP3 in meiotic chromosome organisation

(2014) Johanna Liinamaria Syrjänen et al.   eLife

WAPL-Mediated Removal of Cohesin Protects against Segregation Errors and Aneuploidy

(2013) Judith H.I. Haarhuis et al.   CURRENT BIOLOGY

Homologous Pairing Preceding SPO11-Mediated Double-Strand Breaks in Mice

(2013) Kingsley A. Boateng et al.   DEVELOPMENTAL CELL

Roles of Cohesin and Condensin in Chromosome Dynamics During Mammalian Meiosis

(2013) Jibak LEE   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Wapl is an essential regulator of chromatin structure and chromosome segregation

(2013) Antonio Tedeschi et al.   NATURE

Cytological Studies of Human Meiosis: Sex-Specific Differences in Recombination Originate at, or Prior to, Establishment of Double-Strand Breaks

(2013) Jennifer R. Gruhn et al.   PLoS One

A specific family of interspersed repeats (SINEs) facilitates meiotic synapsis in mammals

(2013) Matthew E Johnson et al.   Molecular Cytogenetics

Meiotic Cohesin SMC1β Provides Prophase I Centromeric Cohesion and Is Required for Multiple Synapsis-Associated Functions

(2013) Uddipta Biswas et al.   PLoS Genetics

Single-Molecule DNA Analysis Reveals That Yeast Hop1 Protein Promotes DNA Folding and Synapsis: Implications for Condensation of Meiotic Chromosomes

(2012) Krishnendu Khan et al.   ACS Nano

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms

(2012) L. Wojtasz et al.   GENES & DEVELOPMENT

HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity

(2012) Hiroshi Kogo et al.   GENES TO CELLS

Meiotic cohesin complexes are essential for the formation of the axial element in mice

(2012) Elena Llano et al.   JOURNAL OF CELL BIOLOGY

Spp1, a Member of the Set1 Complex, Promotes Meiotic DSB Formation in Promoters by Tethering Histone H3K4 Methylation Sites to Chromosome Axes

(2012) Vérane Sommermeyer et al.   MOLECULAR CELL

Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans

(2012) J. Fraune et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meiosis-Specific Noncoding RNA Mediates Robust Pairing of Homologous Chromosomes in Meiosis

(2012) D.-Q. Ding et al.   SCIENCE

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Sister Chromatid Cohesion

(2012) J.-M. Peters et al.   Cold Spring Harbor Perspectives in Biology

Separation of DNA Replication from the Assembly of Break-Competent Meiotic Chromosomes

(2012) Hannah G. Blitzblau et al.   PLoS Genetics

Synaptonemal Complex Components Persist at Centromeres and Are Required for Homologous Centromere Pairing in Mouse Spermatocytes

(2012) C. Gaston Bisig et al.   PLoS Genetics

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

Spo11-Accessory Proteins Link Double-Strand Break Sites to the Chromosome Axis in Early Meiotic Recombination

(2011) Silvia Panizza et al.   CELL

Identification and molecular characterization of the mammalian α-kleisin RAD21L

(2011) Cristina Gutiérrez-Caballero et al.   CELL CYCLE

The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility

(2011) Yurema Herrán et al.   EMBO JOURNAL

A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing

(2011) Kei-ichiro Ishiguro et al.   EMBO REPORTS

RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis

(2011) Jibak Lee et al.   JOURNAL OF CELL BIOLOGY

Cohesin: a catenase with separate entry and exit gates?

(2011) Kim Nasmyth   NATURE CELL BIOLOGY

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1

(2011) Katrin Daniel et al.   NATURE CELL BIOLOGY

Distinct Properties of the XY Pseudoautosomal Region Crucial for Male Meiosis

(2011) L. Kauppi et al.   SCIENCE

Sister Cohesion and Structural Axis Components Mediate Homolog Bias of Meiotic Recombination

(2010) Keun P. Kim et al.   CELL

Synaptonemal Complex Protein SYCP3 Exists in Two Isoforms Showing Different Conservation in Mammalian Evolution

(2010) M. Alsheimer et al.   CYTOGENETIC AND GENOME RESEARCH

Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes

(2010) K. Tachibana-Konwalski et al.   GENES & DEVELOPMENT

Condensin and cohesin complexity: the expanding repertoire of functions

(2010) Andrew J. Wood et al.   NATURE REVIEWS GENETICS

Hormad1 Mutation Disrupts Synaptonemal Complex Formation, Recombination, and Chromosome Segregation in Mammalian Meiosis

(2010) Yong-Hyun Shin et al.   PLoS Genetics

Condensins Regulate Meiotic DNA Break Distribution, thus Crossover Frequency, by Controlling Chromosome Structure

(2009) David G. Mets et al.   CELL

A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes

(2009) Tomoyuki Fukuda et al.   EXPERIMENTAL CELL RESEARCH

Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1

(2009) K. Shintomi et al.   GENES & DEVELOPMENT

The axial element protein HTP-3 promotes cohesin loading and meiotic axis assembly in C. elegans to implement the meiotic program of chromosome segregation

(2009) A. F. Severson et al.   GENES & DEVELOPMENT

Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis

(2009) Hui Jin et al.   JOURNAL OF CELL BIOLOGY

Cohesin SMC1β protects telomeres in meiocytes

(2009) Caroline Adelfalk et al.   JOURNAL OF CELL BIOLOGY

Rec8 Guides Canonical Spo11 Distribution along Yeast Meiotic Chromosomes

(2009) Kazuto Kugou et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential Assembly of Centromeric Proteins in Male Mouse Meiosis

(2009) María Teresa Parra et al.   PLoS Genetics

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

(2009) Lukasz Wojtasz et al.   PLoS Genetics

Protein SYCP2 provides a link between transverse filaments and lateral elements of mammalian synaptonemal complexes

(2008) Karoline Winkel et al.   CHROMOSOMA

Cohesin Smc1β determines meiotic chromatin axis loop organization

(2008) Ivana Novak et al.   JOURNAL OF CELL BIOLOGY

Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis

(2008) G. V. Borner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA