The multifaceted roles of the HORMA domain in cellular signaling

The mammalian autophagy initiator complex contains 2 HORMA domain proteins

(2015) Max Michel et al.   Autophagy

Phosphorylation ofXenopusp31cometpotentiates mitotic checkpoint exit

(2015) Min Mo et al.   CELL CYCLE

Destabilization of pluripotency in the absence of Mad2l2

(2015) Mehdi Pirouz et al.   CELL CYCLE

Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination by Assembling the Meiotic Chromosome Axis

(2015) Takeshi Sakuno et al.   DEVELOPMENTAL CELL

Eukaryotic DNA polymerase ζ

(2015) Alena V. Makarova et al.   DNA REPAIR

TRIP13 PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response

(2015) Christian R. Nelson et al.   JOURNAL OF CELL BIOLOGY

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation

(2015) Hironori Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ

(2015) Junya Tomida et al.   NUCLEIC ACIDS RESEARCH

Structure of an intermediate conformer of the spindle checkpoint protein Mad2

(2015) Mayuko Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation

(2015) Sho W. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex

(2015) Shiqian Qi et al.   STRUCTURE

Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation

(2015) Hironori Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers

(2015) Christophe Lambing et al.   PLoS Genetics

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

(2015) Qiaozhen Ye et al.   eLife

Atomistic Autophagy: The Structures of Cellular Self-Digestion

(2014) James H. Hurley et al.   CELL

HORMA Domains at the Heart of Meiotic Chromosome Dynamics

(2014) Gerben Vader et al.   DEVELOPMENTAL CELL

The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins

(2014) Yumi Kim et al.   DEVELOPMENTAL CELL

A non-sister act: Recombination template choice during meiosis

(2014) Neil Humphryes et al.   EXPERIMENTAL CELL RESEARCH

The HORMA domain: an evolutionarily conserved domain discovered in chromatin-associated proteins, has unanticipated diverse functions

(2014) K. Muniyappa et al.   GENE

The Role of Dbf4-Dependent Protein Kinase in DNA Polymerase ζ-Dependent Mutagenesis in Saccharomyces cerevisiae

(2014) Luis N. Brandão et al.   GENETICS

Thyroid Hormone Receptor Interacting Protein 13 (TRIP13) AAA-ATPase Is a Novel Mitotic Checkpoint-silencing Protein

(2014) Kexi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation Regulates the p31Comet-Mitotic Arrest-deficient 2 (Mad2) Interaction to Promote Spindle Assembly Checkpoint (SAC) Activity

(2014) Dipali A. Date et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homologue engagement controls meiotic DNA break number and distribution

(2014) Drew Thacker et al.   NATURE

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of starvation-induced assembly of the autophagy initiation complex

(2014) Yuko Fujioka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Assembly and dynamics of the autophagy-initiating Atg1 complex

(2014) G. Stjepanovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31comet

(2014) E. Eytan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Meiotic Checkpoint Network: Step-by-Step through Meiotic Prophase

(2014) V. V. Subramanian et al.   Cold Spring Harbor Perspectives in Biology

The Transcription Factor TFII-I Promotes DNA Translesion Synthesis and Genomic Stability

(2014) Farjana J. Fattah et al.   PLoS Genetics

The Putative HORMA Domain Protein Atg101 Dimerizes and Is Required for Starvation-Induced and Selective Autophagy inDrosophila

(2014) Krisztina Hegedűs et al.   Biomed Research International

REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1

(2013) Abel Chiu-Shun Chun et al.   CELL CYCLE

ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

(2013) M. Yamada et al.   GENES & DEVELOPMENT

Numerical constraints and feedback control of double-strand breaks in mouse meiosis

(2013) L. Kauppi et al.   GENES & DEVELOPMENT

The REV7 Subunit of DNA Polymerase ζ Is Essential for Primordial Germ Cell Maintenance in the Mouse

(2013) Naoki Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset

(2013) Tamar Listovsky et al.   JOURNAL OF CELL BIOLOGY

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy

(2013) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1

(2013) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translesion DNA Synthesis and Mutagenesis in Eukaryotes

(2013) J. E. Sale   Cold Spring Harbor Perspectives in Biology

A Critical Function of Mad2l2 in Primordial Germ Cell Development of Mice

(2013) Mehdi Pirouz et al.   PLoS Genetics

Identification of novel mitosis regulators through data mining with human centromere/kinetochore proteins as group queries

(2012) Aaron R Tipton et al.   BMC CELL BIOLOGY

Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

(2012) Michael J. Ragusa et al.   CELL

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins

(2012) Sotaro Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ

(2012) Jessica Wojtaszek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3

(2012) Maheen Ferdous et al.   PLoS Genetics

Structural insights into the assembly of human translesion polymerase complexes

(2012) Wei Xie et al.   Protein & Cell

An Atg13 Protein-mediated Self-association of the Atg1 Protein Kinase Is Important for the Induction of Autophagy

(2011) Yuh-Ying Yeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit

(2011) F. G. Westhorpe et al.   JOURNAL OF CELL SCIENCE

p31comet acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment

(2011) Robert S. Hagan et al.   MOLECULAR BIOLOGY OF THE CELL

Cubism and the cell cycle: the many faces of the APC/C

(2011) Jonathon Pines   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p31comet promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process

(2011) A. Teichner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Checkpoint mechanisms: the puppet masters of meiotic prophase

(2011) Amy J. MacQueen et al.   TRENDS IN CELL BIOLOGY

Quantitative Interaction Proteomics and Genome-wide Profiling of Epigenetic Histone Marks and Their Readers

(2010) Michiel Vermeulen et al.   CELL

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Overlapping in short motif sequences for binding to human REV7 and MAD2 proteins

(2010) Tomo Hanafusa et al.   GENES TO CELLS

Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1

(2010) Kodai Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAIR3, an axis-associated protein, is essential for the recruitment of recombination elements onto meiotic chromosomes in rice

(2010) Kejian Wang et al.   MOLECULAR BIOLOGY OF THE CELL

The Mitotic Arrest Deficient Protein MAD2B Interacts with the Clathrin Light Chain A during Mitosis

(2010) Klaas Medendorp et al.   PLoS One

Hormad1 Mutation Disrupts Synaptonemal Complex Formation, Recombination, and Chromosome Segregation in Mammalian Meiosis

(2010) Yong-Hyun Shin et al.   PLoS Genetics

Purification, crystallization and initial X-ray diffraction study of human REV7 in complex with a REV3 fragment

(2009) Kodai Hara et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

Atg101, a novel mammalian autophagy protein interacting with Atg13

(2009) Nao Hosokawa et al.   Autophagy

A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes

(2009) Tomoyuki Fukuda et al.   EXPERIMENTAL CELL RESEARCH

Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

(2009) L. S. Waters et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Mitotic Arrest Deficient Protein MAD2B Interacts with the Small GTPase RAN throughout the Cell Cycle

(2009) Klaas Medendorp et al.   PLoS One

Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

(2009) Lukasz Wojtasz et al.   PLoS Genetics

HTP-3 Links DSB Formation with Homolog Pairing and Crossing Over during C. elegans Meiosis

(2008) William Goodyer et al.   DEVELOPMENTAL CELL

Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis

(2008) G. V. Borner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Metamorphosis: The Two-State Behavior of Mad2

(2008) Xuelian Luo et al.   STRUCTURE