Journal
CYTOGENETIC AND GENOME RESEARCH
Volume 128, Issue 1-3, Pages 162-168Publisher
KARGER
DOI: 10.1159/000303341
Keywords
Isoforms; Mammals; Meiosis; SYCP3; Synaptonemal complex
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Funding
- DFG [1384]
- Graduate School [1048]
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Meiosis-specific protein SYCP3 is a major structural component of synaptonemal complex (SC) lateral elements. SYCP3 is rather well conserved in vertebrates. However, some differences in SYCP3 expression have been shown among mammals. To clarifiy these differences, we have investigated SYCP3 expression with the aid of bioinformatic, biochemical and cell biological methods. Here we show that, in contrast to other vertebrates, rat and mouse SYCP3 exist in 2 isoforms. The short isoform is conserved among vertebrates. However, the longer isoform, which represents an N-terminal extension of the shorter one, most likely appeared about 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch. Copyright (C) 2010 S. Karger AG, Basel
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