Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia

Targeting the blood-brain barrier for the delivery of stroke therapies

(2021) Anisha D'Souza et al.   ADVANCED DRUG DELIVERY REVIEWS

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats

(2021) Lin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Effect of Exosomes Derived from Bone Marrow Stem Cells in Combination with Rosuvastatin on Functional Recovery and Neuroprotection in Rats After Ischemic Stroke

(2020) Mohsen Safakheil et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

MSCs-Derived Exosomes Attenuate Acute Brain Injury and Inhibit Microglial Inflammation by Reversing CysLT2R-ERK1/2 Mediated Microglia M1 Polarization

(2020) Yangmin Zhao et al.   NEUROCHEMICAL RESEARCH

Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke

(2020) Catriona J. Cunningham et al.   Stem Cell Research & Therapy

Low dose of extracellular vesicles identified that promote recovery after ischemic stroke

(2020) Laura Otero-Ortega et al.   Stem Cell Research & Therapy

Glial Cells: Role of the Immune Response in Ischemic Stroke

(2020) Shenbin Xu et al.   Frontiers in Immunology

Exosomes-carried microRNA-26b-5p regulates microglia M1 polarization after cerebral ischemia/reperfusion

(2020) Guangying Li et al.   CELL CYCLE

Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation

(2020) Hyemee Kim et al.   MOLECULAR THERAPY

Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice

(2020) X. Zheng et al.   Translational Stroke Research

Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: a Randomized Clinical Trial

(2020) Assia Jaillard et al.   Translational Stroke Research

Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation

(2020) Chih-Hsuan Hsia et al.   Journal of Clinical Medicine

The conditioned medium of human embryonic stem cell‐derived mesenchymal stem cells alleviates neurological deficits and improves synaptic recovery in experimental stroke

(2020) Afsaneh Asgari Taei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesenchymal Stromal Cell–Derived Small Extracellular Vesicles Induce Ischemic Neuroprotection by Modulating Leukocytes and Specifically Neutrophils

(2020) Chen Wang et al.   STROKE

Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke

(2020) Yuguo Xia et al.   Stem Cell Research & Therapy

Bone marrow mesenchymal stem cells induce M2 microglia polarization through PDGF-AA/MANF signaling

(2020) Fan Yang et al.   World Journal of Stem Cells

hUCMSCs Mitigate LPS-Induced Trained Immunity in Ischemic Stroke

(2020) Yi-wei Feng et al.   Frontiers in Immunology

Dietary Fe3O4 Nanozymes Prevent the Injury of Neurons and Blood–Brain Barrier Integrity from Cerebral Ischemic Stroke

(2020) Bing Chun Yan et al.   ACS Biomaterials-Science & Engineering

Clinical Applications of Mesenchymal Stem/Stromal Cell Derived Extracellular Vesicles: Therapeutic Potential of an Acellular Product

(2020) Margherita Massa et al.   Diagnostics

Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Stroke: Challenges and Progress

(2019) Oh Young Bang et al.   Frontiers in Neurology

HMG-CoA Reductase Inhibitors Attenuate Neuronal Damage by Suppressing Oxygen Glucose Deprivation-Induced Activated Microglial Cells

(2019) Dan Lu et al.   NEURAL PLASTICITY

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

(2019) Huixin Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3

(2019) Yang Liu et al.   Biomed Research International

Allogeneic adipose-derived mesenchymal stem cell sheet that produces neurological improvement with angiogenesis and neurogenesis in a rat stroke model

(2019) Bikei Ryu et al.   JOURNAL OF NEUROSURGERY

Mesenchymal stem cell–derived extracellular vesicles: a new impetus of promoting angiogenesis in tissue regeneration

(2019) Yinghong Shi et al.   CYTOTHERAPY

Exosomes Secreted by the Cocultures of Normal and Oxygen–Glucose-Deprived Stem Cells Improve Post-stroke Outcome

(2019) Koteswara Rao Nalamolu et al.   NEUROMOLECULAR MEDICINE

Concise Review: Mesenchymal Stem Cells: From Roots to Boost

(2019) Anna Andrzejewska et al.   STEM CELLS

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

Concise Review: Stem Cell Therapy for Stroke Patients: Are We There Yet?

(2019) Cesario V. Borlongan   Stem Cells Translational Medicine

Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome

(2019) Harrell et al.   Cells

Neuroprotective effects of andrographolide derivative CX-10 in transient focal ischemia in rat: Involvement of Nrf2/AE and TLR/NF-κB signaling

(2019) Ming-Yan Yang et al.   PHARMACOLOGICAL RESEARCH

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Stable Intracerebral Transplantation of Neural Stem Cells for the Treatment of Paralysis Due to Ischemic Stroke

(2019) Guangzhu Zhang et al.   Stem Cells Translational Medicine

Topically applied adipose-derived mesenchymal stem cell treatment in experimental focal cerebral ischemia

(2019) Ping Kuen Lam et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial

(2019) Farhaan S. Vahidy et al.   STEM CELLS

Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2

(2019) Yiming Deng et al.   Journal of Biological Engineering

From Tumor Metastasis towards Cerebral Ischemia—Extracellular Vesicles as a General Concept of Intercellular Communication Processes

(2019) Xuan Zheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus–infected human macrophages

(2019) Tshifhiwa Magoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats

(2019) Sylwia Dabrowska et al.   Journal of Neuroinflammation

Phase I/II Study of Safety and Preliminary Efficacy of Intravenous Allogeneic Mesenchymal Stem Cells in Chronic Stroke

(2019) Michael L. Levy et al.   STROKE

Ischaemic stroke

(2019) Bruce C. V. Campbell et al.   Nature Reviews Disease Primers

Achyranthes bidentata polypeptide k suppresses neuroinflammation in BV2 microglia through Nrf2-dependent mechanism

(2019) Qiong Cheng et al.   Annals of Translational Medicine

Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway

(2019) Rui Zhao et al.   NEUROSCIENCE

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Treatment targets for M2 microglia polarization in ischemic stroke

(2018) Ji wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Intravenously Delivered Allogeneic Mesenchymal Stem Cells Bidirectionally Regulate Inflammation and Induce Neurotrophic Effects in Distal Middle Cerebral Artery Occlusion Rats Within the First 7 Days After Stroke

(2018) XiaoBo Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

(2018) Mei Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen–Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis

(2018) Yujia Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

CD8 signaling in microglia/macrophage M1 polarization in a rat model of cerebral ischemia

(2018) Jan Boddaert et al.   PLoS One

Allogeneic Umbilical Cord Blood Infusion for Adults with Ischemic Stroke: Clinical Outcomes from a Phase I Safety Study

(2018) Daniel T. Laskowitz et al.   Stem Cells Translational Medicine

Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke

(2018) Fan Wang et al.   CELL TRANSPLANTATION

Thrombectomy for Acute Ischemic Stroke: Recent Insights and Future Directions

(2018) Aravind Ganesh et al.   Current Neurology and Neuroscience Reports

PGC-1α-Mediated Mitochondrial Biogenesis is Involved in Cannabinoid Receptor 2 Agonist AM1241-Induced Microglial Phenotype Amelioration

(2018) Lei Ma et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

A Mesenchymal stem cell line (B10) increases angiogenesis in a rat MCAO model

(2018) Abdullah Md. Sheikh et al.   EXPERIMENTAL NEUROLOGY

Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization

(2018) Bhakta Prasad Gaire et al.   Journal of Neuroinflammation

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

(2018) Lijuan Zhang et al.   Frontiers in Cellular Neuroscience

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

(2018) Guanguan Qiu et al.   Stem Cell Research & Therapy

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

(2018) Gyeong Joon Moon et al.   Translational Stroke Research

Bone marrow mesenchymal stem cell transplantation exerts neuroprotective effects following cerebral ischemia/reperfusion injury by inhibiting autophagy via the PI3K/Akt pathway

(2018) He He et al.   BRAIN RESEARCH

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions

(2017) Revathy Guruswamy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke

(2017) Susumu Yamaguchi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke

(2017) Laura Otero-Ortega et al.   Scientific Reports

Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

(2017) Masataka Nakajima et al.   Molecular Therapy-Methods & Clinical Development

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice

(2016) Zhao-Ma Shu et al.   CNS Neuroscience & Therapeutics

The effect of ultrasound for increasing neural differentiation in hBM-MSCs and inducing neurogenesis in ischemic stroke model

(2016) Sang-Eun Cho et al.   LIFE SCIENCES

Microglia and Monocyte-Derived Macrophages in Stroke

(2016) Eunhee Kim et al.   Neurotherapeutics

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Interleukin-1 in Stroke

(2016) Oluwaseun A. Sobowale et al.   STROKE

Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury

(2016) Bingke Lv et al.   Frontiers in Cellular Neuroscience

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

(2016) Jiho Jang et al.   Nature Communications

Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke

(2016) Kuan-Hung Chen et al.   Oncotarget

Microvesicles from brain-extract—treated mesenchymal stem cells improve neurological functions in a rat model of ischemic stroke

(2016) Ji Yong Lee et al.   Scientific Reports

Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

(2015) Masato Kanazawa et al.   BRAIN

Endocannabinoids drive the acquisition of an alternative phenotype in microglia

(2015) M. Mecha et al.   BRAIN BEHAVIOR AND IMMUNITY

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

(2015) Clare H Latta et al.   Journal of Neuroinflammation

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Enhanced angiogenesis promoted by human umbilical mesenchymal stem cell transplantation in stroked mouse is Notch1 signaling associated

(2015) J. Zhu et al.   NEUROSCIENCE

Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice

(2015) Guo-wen Hu et al.   Stem Cell Research & Therapy

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

The Ischemic Environment Drives Microglia and Macrophage Function

(2015) Stefano Fumagalli et al.   Frontiers in Neurology

Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms

(2015) Atsuhiko Toyoshima et al.   PLoS One

Intracerebral Implantation of Autologous Peripheral Blood Stem Cells in Stroke Patients: A Randomized Phase II Study

(2014) Der-Cherng Chen et al.   CELL TRANSPLANTATION

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke

(2014) Liu-Qing Wang et al.   CNS Neuroscience & Therapeutics

Reparative Therapy for Acute Ischemic Stroke with Allogeneic Mesenchymal Stem Cells from Adipose Tissue: A Safety Assessment

(2014) Exuperio Díez-Tejedor et al.   Journal of Stroke & Cerebrovascular Diseases

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis

(2014) Annelies Bronckaers et al.   PHARMACOLOGY & THERAPEUTICS

Intravenous Autologous Bone Marrow Mononuclear Stem Cell Therapy for Ischemic Stroke

(2014) Kameshwar Prasad et al.   STROKE

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Ischemic brain injury: A consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction

(2013) Colin P. McGuckin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Feasibility of Delivering Mesenchymal Stem Cells via Catheter to the Proximal End of the Lesion Artery in Patients with Stroke in the Territory of the Middle Cerebral Artery

(2013) Yongjun Jiang et al.   CELL TRANSPLANTATION

A Double-Blind Placebo-Controlled Clinical Evaluation of Multistem for the Treatment of Ischemic Stroke

(2013) David C. Hess et al.   International Journal of Stroke

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MicroRNAs in Cerebral Ischemia-Induced Neurogenesis

(2013) Xian Shuang Liu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human mesenchymal stem cell transplantation changes proinflammatory gene expression through a nuclear factor-κB-dependent pathway in a rat focal cerebral ischemic model

(2013) Hui Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Immune following suppression mesenchymal stem cell transplantation in the ischemic brain is mediated by TGF-β

(2013) Seung-Wan Yoo et al.   NEUROBIOLOGY OF DISEASE

Human Mesenchymal Stem Cell Microvesicles for Treatment ofEscherichia coliEndotoxin-Induced Acute Lung Injury in Mice

(2013) Ying-gang Zhu et al.   STEM CELLS

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

(2013) Bin Zhang et al.   STEM CELLS AND DEVELOPMENT

Intra-arterial Cell Transplantation Provides Timing-Dependent Cell Distribution and Functional Recovery After Stroke

(2013) Shunsuke Ishizaka et al.   STROKE

Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhances angiogenesis and neurogenesis after cerebral ischemia in rats

(2012) Ling Wei et al.   NEUROBIOLOGY OF DISEASE

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

(2012) Manoj M. Lalu et al.   PLoS One

Intra-Arterial Bone Marrow Mononuclear Cells in Ischemic Stroke

(2012) Francisco Moniche et al.   STROKE

Intravenous autologous bone marrow mononuclear cells for ischemic stroke

(2011) Sean I. Savitz et al.   ANNALS OF NEUROLOGY

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mesenchymal stem cell transplantation modulates neuroinflammation in focal cerebral ischemia: Contribution of fractalkine and IL-5

(2010) Abdullah Md. Sheikh et al.   NEUROBIOLOGY OF DISEASE

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Mouse Bone Marrow-Derived Mesenchymal Stromal Cells Turn Activated Macrophages into a Regulatory-Like Profile

(2010) Julian Maggini et al.   PLoS One

A Long-Term Follow-Up Study of Intravenous Autologous Mesenchymal Stem Cell Transplantation in Patients With Ischemic Stroke

(2010) Jin Soo Lee et al.   STEM CELLS

Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition

(2009) Dashdemberel Narantuya et al.   BRAIN RESEARCH

PTEN regulate angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells

(2009) Jiachi Ma et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice

(2009) Qindong Shi et al.   NEUROSCIENCE LETTERS

Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia

(2008) Kentaro Toyama et al.   EXPERIMENTAL NEUROLOGY

Acute ischaemic stroke and infection: recent and emerging concepts

(2008) Hedley CA Emsley et al.   LANCET NEUROLOGY

Systemic infection, inflammation and acute ischemic stroke

(2008) B.W. McColl et al.   NEUROSCIENCE