Targeting the blood-brain barrier for the delivery of stroke therapies

The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

(2020) Thai Thanh Hoang Thi et al.   Polymers

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Extracellular Vesicles as Signaling Mediators and Disease Biomarkers across Biological Barriers

(2020) Pasquale Simeone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ultrasound-responsive neurotrophic factor-loaded microbubble- liposome complex: Preclinical investigation for Parkinson's disease treatment

(2020) Chung-Yin Lin et al.   JOURNAL OF CONTROLLED RELEASE

Hyperacute Management of Ischemic Strokes

(2020) Pratit Patel et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Challenges in the development and establishment of exosome-based drug delivery systems

(2020) Jin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

(2019) Asif Manzoor Khan et al.   Nanotoxicology

Transcytosis to Cross the Blood Brain Barrier, New Advancements and Challenges

(2019) Victor M. Pulgar   Frontiers in Neuroscience

Embryonic Stem Cells‐Derived Exosomes Endowed with Targeting Properties as Chemotherapeutics Delivery Vehicles for Glioblastoma Therapy

(2019) Qingwei Zhu et al.   Advanced Science

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

(2019) Huixin Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Advances in nanocarriers enabled brain targeted drug delivery across blood brain barrier

(2019) Garima Sharma et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential

(2019) Vibhuti Agrahari et al.   ADVANCED DRUG DELIVERY REVIEWS

Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles

(2019) Sara Busatto et al.   BIOMEDICAL MICRODEVICES

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

(2019) Olivier G. de Jong et al.   ACCOUNTS OF CHEMICAL RESEARCH

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

(2019) Rebecca Parodi-Rullán et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation: friend and foe for ischemic stroke

(2019) Richard L. Jayaraj et al.   Journal of Neuroinflammation

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy

(2019) Masamitsu Kanada et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic Potential of Neurotrophins for Repair After Brain Injury: A Helping Hand From Biomaterials

(2019) Josh Houlton et al.   Frontiers in Neuroscience

The Development of Functional Non-Viral Vectors for Gene Delivery

(2019) Patil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy

(2019) Minkyung Kim et al.   Journal of Biomedical Nanotechnology

Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

(2019) Morgan D. McSweeney et al.   JOURNAL OF CONTROLLED RELEASE

Progress of Research on Exosomes in the Protection Against Ischemic Brain Injury

(2019) Xianhui Kang et al.   Frontiers in Neuroscience

Evolution of Nanoparticle Protein Corona across the Blood–Brain Barrier

(2018) Alysia Cox et al.   ACS Nano

Noninvasive, targeted gene therapy for acute spinal cord injury using LIFU-mediated BDNF-loaded cationic nanobubble destruction

(2018) Zhaojun Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Transplantation of BDNF Gene Recombinant Mesenchymal Stem Cel ls and Adhesive Peptide-modified Hydrogel Scaffold for Spinal Cord Repa ir

(2018) Li-Ming Li et al.   CURRENT GENE THERAPY

Extracellular vesicle therapeutics for liver disease

(2018) David A. Borrelli et al.   JOURNAL OF CONTROLLED RELEASE

Role of Autophagy in Endothelial Damage and Blood–Brain Barrier Disruption in Ischemic Stroke

(2018) Kyeong-A Kim et al.   STROKE

ARMMs as a versatile platform for intracellular delivery of macromolecules

(2018) Qiyu Wang et al.   Nature Communications

Current Strategies for Brain Drug Delivery

(2018) Xiaowei Dong   Theranostics

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends

(2018) Maria Yu. Konoshenko et al.   Biomed Research International

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

(2018) Sarah Caruso et al.   Frontiers in Immunology

Extracellular vesicles: intelligent delivery strategies for therapeutic applications

(2018) Alice Pinheiro et al.   JOURNAL OF CONTROLLED RELEASE

Circulating Extracellular Vesicles in Human Disease

(2018) Ravi Shah et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria in Ischemic Stroke: New Insight and Implications

(2018) Fan Liu et al.   Aging and Disease

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

(2018) Yu Jiang et al.   ACS Nano

Emerging Technologies for Delivery of Biotherapeutics and Gene Therapy Across the Blood–Brain Barrier

(2018) Danica B. Stanimirovic et al.   BIODRUGS

Potential of Exosomes for the Treatment of Stroke

(2018) Shi-Bin Hong et al.   CELL TRANSPLANTATION

Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem®-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke

(2018) Kristine Ravina et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes: natural nanoparticles as bio shuttles for RNAi delivery

(2018) Saber Ghazizadeh Darband et al.   JOURNAL OF CONTROLLED RELEASE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Nanotechnology-mediated crossing of two impermeable membranes to modulate the stars of the neurovascular unit for neuroprotection

(2018) Bapurao Surnar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood-Brain Delivery Methods Using Nanotechnology

(2018) Daniel Teleanu et al.   Pharmaceutics

Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

(2017) L Jiang et al.   GENE THERAPY

Adjunctive Therapy Approaches for Ischemic Stroke: Innovations to Expand Time Window of Treatment

(2017) Talia Knecht et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

(2017) Imre Mäger et al.   NEUROPHARMACOLOGY

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury

(2017) Yejie Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model

(2017) Tao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants

(2017) Maurizio Bruschi et al.   Proteomics Clinical Applications

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein

(2017) Maoxue Tang et al.   Nature Communications

Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

(2017) Jialei Yang et al.   Molecular Therapy-Nucleic Acids

Recent Advances in Nanomaterials for Gene Delivery—A Review

(2017) Michael Riley et al.   Nanomaterials

Evolution of blood-brain-barrier permeability after acute ischemic stroke

(2017) Zamir Merali et al.   PLoS One

Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases

(2016) Anna M. Janas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia

(2016) Somayyeh Hamzei Taj et al.   BIOMATERIALS

Stroke: a global response is needed

(2016) Walter Johnson et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

(2016) Tek N. Lamichhane et al.   Cellular and Molecular Bioengineering

Blood–brain barrier shuttle peptides: an emerging paradigm for brain delivery

(2016) Benjamí Oller-Salvia et al.   CHEMICAL SOCIETY REVIEWS

Glial-endothelial crosstalk regulates blood–brain barrier function

(2016) Lara Cheslow et al.   CURRENT OPINION IN PHARMACOLOGY

Brain endothelial cell‐targeted gene therapy of neurovascular disorders

(2016) Serena Marchiò et al.   EMBO Molecular Medicine

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

(2016) Jakob Körbelin et al.   EMBO Molecular Medicine

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

(2016) Scott W. Ferguson et al.   JOURNAL OF CONTROLLED RELEASE

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

Non-viral liposome-mediated transfer of brain-derived neurotrophic factor across the blood-brain barrier

(2016) Zong-xin Xia et al.   Neural Regeneration Research

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

The Mystery of Antibodies Against Polyethylene Glycol (PEG) - What do we Know?

(2016) Christian Lubich et al.   PHARMACEUTICAL RESEARCH

Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery

(2016) Nia M. Harris et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke

(2016) Tara M. Stanne et al.   STROKE

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

(2016) Yejie Shi et al.   Nature Communications

Intranasal Delivery of Recombinant AAV Containing BDNF Fused with HA2TAT: a Potential Promising Therapy Strategy for Major Depressive Disorder

(2016) Xian-cang Ma et al.   Scientific Reports

Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor

(2016) Hong Chen et al.   Scientific Reports

The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995–2015

(2016) Xiaoling Chen et al.   Acta Pharmaceutica Sinica B

Temporal assessment of nanoparticle accumulation after experimental brain injury: Effect of particle size

(2016) Vimala N. Bharadwaj et al.   Scientific Reports

Applying the Retro-Enantio Approach To Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier

(2015) Roger Prades et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

(2015) Michelle E. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internalization of targeted quantum dots by brain capillary endothelial cells in vivo

(2015) Sarah Paris-Robidas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apicobasal polarity of brain endothelial cells

(2015) Thomas Worzfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A critical evaluation of drug delivery from ligand modified nanoparticles: Confounding small molecule distribution and efficacy in the central nervous system

(2015) Rebecca L. Cook et al.   JOURNAL OF CONTROLLED RELEASE

Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease

(2015) Maarten Rotman et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Bilayer Crossing—The Gate of Symmetry. Water-Soluble Phenylproline-Based Blood-Brain Barrier Shuttles

(2015) Pol Arranz-Gibert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rescue of Brain Function Using Tunneling Nanotubes Between Neural Stem Cells and Brain Microvascular Endothelial Cells

(2015) Xiaoqing Wang et al.   MOLECULAR NEUROBIOLOGY

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke

(2015) Qi-jin Yu et al.   Neural Regeneration Research

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

(2015) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery

(2014) Shivani Rai Paliwal et al.   DRUG DELIVERY

Polymersomes conjugated to 83-14 monoclonal antibodies: Invitro targeting of brain capillary endothelial cells

(2014) Le-Ha Dieu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

(2014) William M Pardridge   Expert Opinion on Drug Delivery

Post-stroke recovery: the role of activity-dependent release of brain-derived neurotrophic factor

(2014) Antonio Berretta et al.   Expert Review of Neurotherapeutics

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

(2014) Hong Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Brain-derived neurotrophic factor in the airways

(2014) Y.S. Prakash et al.   PHARMACOLOGY & THERAPEUTICS

Correction: A Unique Carrier for Delivery of Therapeutic Compounds beyond the Blood-Brain Barrier

(2014) Delara Karkan et al.   PLoS One

Current Status of Cell Therapies in Stroke

(2014) Oh Young Bang   International Journal of Stem Cells

LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma

(2013) Bo Zhang et al.   BIOMATERIALS

Dual system for the central nervous system targeting and blood-brain barrier transport of a selective prolyl oligopeptidase inhibitor

(2013) Meritxell Teixidó et al.   BIOPOLYMERS

Successes and Failures for Drugs in Late-Stage Development for Alzheimer’s Disease

(2013) Camryn Berk et al.   DRUGS & AGING

In Vitro and in Vivo Evaluation of Lactoferrin-Conjugated Liposomes as a Novel Carrier to Improve the Brain Delivery

(2013) Feng-Yun Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution

(2013) Antonietta Vilella et al.   JOURNAL OF CONTROLLED RELEASE

Solid lipid nanoparticles carrying chemotherapeutic drug across the blood–brain barrier through insulin receptor-mediated pathway

(2013) Yung-Chih Kuo et al.   JOURNAL OF DRUG TARGETING

Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury

(2013) Yu Okuma et al.   NEUROSCIENCE LETTERS

Angiopep-Conjugated Nanoparticles for Targeted Long-Term Gene Therapy of Parkinson’s Disease

(2013) Rongqin Huang et al.   PHARMACEUTICAL RESEARCH

Targeted Brain Derived Neurotropic Factors (BDNF) Delivery across the Blood-Brain Barrier for Neuro-Protection Using Magnetic Nano Carriers: An In-Vitro Study

(2013) Sudheesh Pilakka-Kanthikeel et al.   PLoS One

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

(2013) D. T. Wiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

Stroke Unit Care Benefits Patients With Intracerebral Hemorrhage

(2013) Peter Langhorne et al.   STROKE

Peroxiredoxin 2 Battles Poly(ADP-Ribose) Polymerase 1- and p53-Dependent Prodeath Pathways After Ischemic Injury

(2013) Rehana K. Leak et al.   STROKE

Microvesicles

(2013) Ming-Lin Liu et al.   Current Opinion in Endocrinology Diabetes and Obesity

From Molecular to Nanotechnology Strategies for Delivery of Neurotrophins: Emphasis on Brain-Derived Neurotrophic Factor (BDNF)

(2013) Claire Géral et al.   Pharmaceutics

Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes

(2012) Julia V. Georgieva et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor

(2012) Roger Prades et al.   BIOMATERIALS

Antithrombotic and Thrombolytic Therapy for Ischemic Stroke

(2012) Maarten G. Lansberg et al.   CHEST

The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target

(2012) R Anne Stetler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amelioration of cerebral ischemia–reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin

(2012) Takayuki Ishii et al.   JOURNAL OF CONTROLLED RELEASE

Phosphorylation of HSP27 by Protein Kinase D Is Essential for Mediating Neuroprotection against Ischemic Neuronal Injury

(2012) R. A. Stetler et al.   JOURNAL OF NEUROSCIENCE

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

(2012) Casey A Maguire et al.   MOLECULAR THERAPY

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted gene delivery to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

(2011) Qin Huang et al.   EXPERIMENTAL NEUROLOGY

Mitochondrial ATP synthase: architecture, function and pathology

(2011) An I. Jonckheere et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke

(2011) Trent M Woodruff et al.   Molecular Neurodegeneration

In Vivo Labeling of Brain Capillary Endothelial Cells after Intravenous Injection of Monoclonal Antibodies Targeting the Transferrin Receptor

(2011) S. Paris-Robidas et al.   MOLECULAR PHARMACOLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Neuroprotection With Intraventricular Brain-Derived Neurotrophic Factor in Rat Venous Occlusion Model

(2011) Yasuhiro Takeshima et al.   NEUROSURGERY

Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System

(2011) Francisco C. Pérez-Martínez et al.   PHARMACEUTICAL RESEARCH

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

(2011) Y. J. Yu et al.   Science Translational Medicine

Multidrug resistance associated proteins in multidrug resistance

(2011) Kamlesh Sodani et al.   Chinese Journal of Cancer

Leptin-derived peptide, a targeting ligand for mouse brain-derived endothelial cells via macropinocytosis

(2010) Mina Tamaru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential neurotoxicity of nanoparticles

(2010) Yu-Lan Hu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cell Number and Timing of Transplantation Determine Survival of Human Neural Stem Cell Grafts in Stroke-Damaged Rat Brain

(2010) Vladimer Darsalia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain

(2010) Inge van Rooy et al.   JOURNAL OF CONTROLLED RELEASE

Targeting the insulin receptor: nanoparticles for drug delivery across the blood–brain barrier (BBB)

(2010) Karsten Ulbrich et al.   JOURNAL OF DRUG TARGETING

Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models

(2010) Heath D Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Complement Activation by Polymers Carrying Hydroxyl Groups

(2009) Yusuke Arima et al.   ACS Applied Materials & Interfaces

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Minimal penetration of lipopolysaccharide across the murine blood–brain barrier

(2009) William A. Banks et al.   BRAIN BEHAVIOR AND IMMUNITY

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

(2009) Sandra R. Alcalá-Barraza et al.   JOURNAL OF DRUG TARGETING

Brain delivery and systemic effect of cationic albumin conjugated PLGA nanoparticles

(2009) Feng Xu et al.   JOURNAL OF DRUG TARGETING

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

(2009) Anna Valeria Vergoni et al.   Nanomedicine-Nanotechnology Biology and Medicine

Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy

(2009) Yong Hong Chen et al.   NATURE MEDICINE

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Re-Engineering Biopharmaceuticals for Delivery to Brain with Molecular Trojan Horses

(2008) William M. Pardridge   BIOCONJUGATE CHEMISTRY

TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs

(2008) Kavitha S. Rao et al.   BIOMATERIALS

Physiological Pathway for Low-Density Lipoproteins across the Blood-Brain Barrier: Transcytosis through Brain Capillary Endothelial Cells In Vitro

(2008) Pietra Candela et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

(2008) Ryan G. Soderquist et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26

(2008) Zhiqing Pang et al.   JOURNAL OF CONTROLLED RELEASE

Hsp27 Protects against Ischemic Brain Injury via Attenuation of a Novel Stress-Response Cascade Upstream of Mitochondrial Cell Death Signaling

(2008) R. A. Stetler et al.   JOURNAL OF NEUROSCIENCE

Intracellular Drug Delivery by Poly(lactic-co-glycolic acid) Nanoparticles, Revisited

(2008) Peisheng Xu et al.   MOLECULAR PHARMACEUTICS

Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning?

(2008) Ulrich Dirnagl et al.   NEUROPHARMACOLOGY

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons

(2008) S. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging

(2008) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

(2008) J.-i. Tanaka et al.   SCIENCE

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

(2008) Nickolai Sheikov et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

GDNF fusion protein for targeted-drug delivery across the human blood–brain barrier

(2007) Ruben J. Boado et al.   BIOTECHNOLOGY AND BIOENGINEERING