Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Zika virus infected primary microglia impairs NPCs proliferation and differentiation

(2018) Jin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Persistent Increase in Microglial RAGE Contributes to Chronic Stress–Induced Priming of Depressive-like Behavior

(2018) Tina C. Franklin et al.   BIOLOGICAL PSYCHIATRY

High mobility group box-1 (HMGB1) is increased in injured mouse spinal cord and can elicit neurotoxic inflammation

(2018) Kristina A. Kigerl et al.   BRAIN BEHAVIOR AND IMMUNITY

The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke

(2018) Qingqing Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Atomoxetine, a selective norepinephrine reuptake inhibitor, improves short-term histological outcomes after hypoxic-ischemic brain injury in the neonatal male rat

(2018) Masatake Toshimitsu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures

(2018) Joanna Ślusarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Different levels of pro- and anti-inflammatory cytokines in patients with unipolar and bipolar depression

(2018) Ruizhi Mao et al.   JOURNAL OF AFFECTIVE DISORDERS

Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats

(2018) Ya-Lin Wang et al.   Journal of Neuroinflammation

Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice

(2018) Joanna Ruth Appel et al.   JOURNAL OF NEUROSCIENCE

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

(2018) Akiko Miki et al.   OPHTHALMOLOGICA

A P2X7 receptor antagonist reverses behavioural alterations, microglial activation and neuroendocrine dysregulation in an unpredictable chronic mild stress (UCMS) model of depression in mice

(2018) Rai Khalid Farooq et al.   PSYCHONEUROENDOCRINOLOGY

Disruption of the Microglial ADP Receptor P2Y13 Enhances Adult Hippocampal Neurogenesis

(2018) Jennifer Stefani et al.   Frontiers in Cellular Neuroscience

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice

(2018) Wenjuan Yang et al.   Frontiers in Aging Neuroscience

RhoA/ROCK-2 Pathway Inhibition and Tight Junction Protein Upregulation by Catalpol Suppresses Lipopolysaccaride-Induced Disruption of Blood-Brain Barrier Permeability

(2018) Shan Feng et al.   MOLECULES

Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation

(2017) Meetu Wadhwa et al.   Journal of Neuroinflammation

Combined effect of BCG vaccination and enriched environment promote neurogenesis and spatial cognition via a shift in meningeal macrophage M2 polarization

(2017) Fangfang Qi et al.   Journal of Neuroinflammation

The effects of sEH inhibitor on depression-like behavior and neurogenesis in male mice

(2017) Qiong Wu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses

(2017) Lijuan Tong et al.   NEUROCHEMICAL RESEARCH

The Secretome of Microglia Regulate Neural Stem Cell Function

(2017) Ahmed M. Osman et al.   NEUROSCIENCE

Microglia: An Interface between the Loss of Neuroplasticity and Depression

(2017) Gaurav Singhal et al.   Frontiers in Cellular Neuroscience

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

(2017) Aleksandra Deczkowska et al.   Nature Communications

M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway

(2017) Jichao Yuan et al.   Oncotarget

Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates

(2017) Feng Zhang et al.   Frontiers in Aging Neuroscience

Salvianolic acid B ameliorates depressive-like behaviors in chronic mild stress-treated mice: involvement of the neuroinflammatory pathway

(2016) Jin-qiang Zhang et al.   ACTA PHARMACOLOGICA SINICA

Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

(2016) Sabine Hellwig et al.   BRAIN BEHAVIOR AND IMMUNITY

Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life

(2016) Junhua Yang et al.   BRAIN RESEARCH BULLETIN

Differential regulation of NSC phenotype and genotype by chronically activated microglia within cocultures

(2016) Kurt Farrell et al.   Integrative Biology

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

(2016) Christopher S. von Bartheld et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Experimental Cortical Spreading Depression Induces NMDA Receptor Dependent Potassium Currents in Microglia

(2016) S. Wendt et al.   JOURNAL OF NEUROSCIENCE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Hippocampal neurogenesis dysfunction linked to depressive-like behaviors in a neuroinflammation induced model of depression

(2016) Ming-ming Tang et al.   PHYSIOLOGY & BEHAVIOR

Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10

(2015) Beatriz Almolda et al.   BRAIN BEHAVIOR AND IMMUNITY

Atypical Neurotransmitters and the Neurobiology of Depression

(2015) Samia Joca et al.   CNS & Neurological Disorders-Drug Targets

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Effects of Microglia on Neurogenesis

(2015) Kaoru Sato   GLIA

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood

(2015) A.M. Depino   NEUROSCIENCE

Blockade of nociceptin/orphanin FQ receptor signaling reverses LPS-induced depressive-like behavior in mice

(2015) Iris U. Medeiros et al.   PEPTIDES

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Molecular and epigenetic basis of macrophage polarized activation

(2015) Chiara Porta et al.   SEMINARS IN IMMUNOLOGY

HPA-axis stress reactivity in youth depression: evidence of impaired regulatory processes in depressed boys

(2015) Nestor L. Lopez-Duran et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Glia in the cytokine-mediated onset of depression: fine tuning the immune response

(2015) Wendy K. Jo et al.   Frontiers in Cellular Neuroscience

NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

(2015) Audrey Gustin et al.   PLoS One

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis

(2014) Ronen Reshef et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia are polarized to M1 type in high-anxiety inbred mice in response to lipopolysaccharide challenge

(2014) Zhilin Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia

(2014) Chittappen K. Prajeeth et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

(2014) Susana G. Torres-Platas et al.   BRAIN BEHAVIOR AND IMMUNITY

Neonatal Peripheral Immune Challenge Activates Microglia and Inhibits Neurogenesis in the Developing Murine Hippocampus

(2014) Peter L.P. Smith et al.   DEVELOPMENTAL NEUROSCIENCE

A review of the relationship between proinflammatory cytokines and major depressive disorder

(2014) Juan Joseph Young et al.   JOURNAL OF AFFECTIVE DISORDERS

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation

(2014) Rocío M de Pablos et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury

(2014) Kentaro Hayakawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Current perspectives on the link between neuroinflammation and neurogenesis

(2014) Brian Wang et al.   METABOLIC BRAIN DISEASE

Impact of indomethacin on neuroinflammation and hippocampal neurogenesis in aged mice

(2014) Marcus Boehme et al.   NEUROSCIENCE LETTERS

Dysregulation of the hypothalamus-pituitary-adrenal axis predicts some aspects of the behavioral response to chronic fluoxetine: association with hippocampal cell proliferation

(2014) Wahid Khemissi et al.   Frontiers in Behavioral Neuroscience

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

(2014) Amanda Sierra et al.   NEURAL PLASTICITY

Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory

(2014) Jorge Valero et al.   Frontiers in Neuroscience

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Involvement of MicroRNA in Microglia-Mediated Immune Response

(2013) J. Guedes et al.   Clinical & Developmental Immunology

Early-life stress and HPA axis trigger recurrent adulthood depression

(2013) Mario F. Juruena   EPILEPSY & BEHAVIOR

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

miRNA–transcription factor interactions: a combinatorial regulation of gene expression

(2013) S. Arora et al.   MOLECULAR GENETICS AND GENOMICS

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Imipramine treatment increases cell proliferation following fluid percussion brain injury in rats

(2013) J Zhang et al.   NEUROLOGICAL RESEARCH

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia

(2013) Robert W. Freilich et al.   PLoS One

The role of microglia in adult hippocampal neurogenesis

(2013) Carmelina Gemma et al.   Frontiers in Cellular Neuroscience

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

Microglia Control Neuronal Network Excitability via BDNF Signalling

(2013) Francesco Ferrini et al.   NEURAL PLASTICITY

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

(2012) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response

(2012) Timothy R. Powell et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS

(2012) Eugene D. Ponomarev et al.   GLIA

Corticosterone suppresses the proliferation of BV2 microglia cells via glucocorticoid, but not mineralocorticoid receptor

(2012) Yoshihiko Nakatani et al.   LIFE SCIENCES

Modelling Neuroinflammation In Vitro: A Tool to Test the Potential Neuroprotective Effect of Anti-Inflammatory Agents

(2012) Núria Gresa-Arribas et al.   PLoS One

Inflammatory Factors Contribute to Depression and Its Comorbid Conditions

(2012) H. Anisman et al.   Science Signaling

Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: Involvement in depression

(2011) Zili You et al.   BEHAVIOURAL BRAIN RESEARCH

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

(2011) K.-W. Kim et al.   BLOOD

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Lipopolysaccharide acutely inhibits proliferation of neural precursor cells in the dentate gyrus in adult rats

(2010) Hitomi Fujioka et al.   BRAIN RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

A psychoneuroimmunological review on cytokines involved in antidepressant treatment response

(2010) Debbie G. A. Janssen et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Early microglial colonization of the human forebrain and possible involvement in periventricular white-matter injury of preterm infants

(2010) Catherine Verney et al.   JOURNAL OF ANATOMY

Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid   Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme

(2010) Y. Kong et al.   JOURNAL OF NEUROSCIENCE

Microglia and neuroprotection: From in vitro studies to therapeutic applications

(2010) Elisabetta Polazzi et al.   PROGRESS IN NEUROBIOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury

(2009) Seija Lehnardt   GLIA

Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?

(2009) Lucile Capuron et al.   JOURNAL OF AFFECTIVE DISORDERS

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus

(2009) A.M. Espinosa-Oliva et al.   NEUROBIOLOGY OF AGING

Early-life programming of later-life brain and behavior: a critical role for the immune system

(2009) Staci D. Bilbo   Frontiers in Behavioral Neuroscience

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

(2008) Gaylia Jean Harry et al.   Expert Opinion on Drug Metabolism & Toxicology

Cell cycle regulation, neurogenesis, and depression

(2008) K. A. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

(2006) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH