Synthetic Ruthenium Complex TQ-6 Potently Recovers Cerebral Ischemic Stroke: Attenuation of Microglia and Platelet Activation

Antiplatelet Therapy in Ischemic Stroke and Transient Ischemic Attack

(2019) Daniel G. Hackam et al.   STROKE

Possible Molecular Targets of Novel Ruthenium Complexes in Antiplatelet Therapy

(2018) Thanasekaran Jayakumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

(2018) Sreekanth Thota et al.   JOURNAL OF MEDICINAL CHEMISTRY

Clinical Significance of Acute and Serial Platelet Function Testing in Acute Ischemic Stroke

(2018) Joon‐Tae Kim et al.   Journal of the American Heart Association

Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling

(2017) Ravikanth Velagapudi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation

(2017) Joen-Rong Sheu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Advances in the design of organometallic anticancer complexes

(2017) Pingyu Zhang et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Tryptanthrin Suppresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling

(2017) Young-Won Kwon et al.   Frontiers in Cellular Neuroscience

A novel ruthenium (II)-derived organometallic compound, TQ-6, potently inhibits platelet aggregation: Ex vivo and in vivo studies

(2017) Chih-Hsuan Hsia et al.   Scientific Reports

Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice

(2016) Zhao-Ma Shu et al.   CNS Neuroscience & Therapeutics

PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microglia

(2016) Antonia Cianciulli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Prevention of arterial thrombosis by nobiletin: in vitro and in vivo studies

(2016) Wan-Jung Lu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Andrographolide stimulates p38 mitogen-activated protein kinase–nuclear factor erythroid-2-related factor 2–heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats

(2016) Ting-Lin Yen et al.   Translational Research

Transcription factor NF-κB associates with microtubules and stimulates apoptosis in response to suppression of microtubule dynamics in MCF-7 cells

(2015) Ankit Rai et al.   BIOCHEMICAL PHARMACOLOGY

Innate and adaptive immune response in stroke: Focus on epigenetic regulation

(2015) Antonietta Picascia et al.   JOURNAL OF NEUROIMMUNOLOGY

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

(2015) Yang Li et al.   NEUROCHEMICAL RESEARCH

Long‐Term Antiplatelet Mono‐ and Dual Therapies After Ischemic Stroke or Transient Ischemic Attack: Network Meta‐Analysis

(2015) Wuxiang Xie et al.   Journal of the American Heart Association

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling

(2014) Tsung-Ming Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation

(2014) N. G. Innamorato et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Strategic Selection of Neuroinflammatory Models in Parkinson's Disease: Evidence from Experimental Studies

(2013) Sandeep More et al.   CNS & Neurological Disorders-Drug Targets

Progressive Neurodegeneration After Experimental Brain Trauma

(2013) David J. Loane et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

New Ruthenium(II)–Letrozole Complexes as Anticancer Therapeutics

(2012) Annie Castonguay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

(2012) M. Lalancette-Hebert et al.   JOURNAL OF NEUROSCIENCE

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

(2011) Agnieszka Jazwa et al.   ANTIOXIDANTS & REDOX SIGNALING

Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice

(2011) Carlo Perego et al.   Journal of Neuroinflammation

Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: New class of analgesic and anti-inflammatory agents

(2010) Rekha S. Hoonur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials

(2009)   LANCET

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

(2008) G. Stoll et al.   BLOOD

Inflammation as Therapeutic Objective in Stroke

(2008) Joaquin Jordan et al.   CURRENT PHARMACEUTICAL DESIGN

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

(2008) Pär Thored et al.   GLIA