Emerging Roles of Small GTPases in Islet β-Cell Function

Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3

(2021) Yi Sun et al.   Cell Reports

ABCA12 regulates insulin secretion from β‐cells

(2020) Gloria M Ursino et al.   EMBO REPORTS

Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics

(2020) Nicole A. J. Krentz et al.   Nature Reviews Endocrinology

Glucose transporters in pancreatic islets

(2020) Constantin Berger et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

β-cell secretory dysfunction: a key cause of type 2 diabetes

(2020) Rury R Holman et al.   Lancet Diabetes & Endocrinology

Loss of Caveolin-1 Is Associated with a Decrease in Beta Cell Death in Mice on a High Fat Diet

(2020) Paloma Lillo Urzúa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diet and exercise in the prevention and treatment of type 2 diabetes mellitus

(2020) Faidon Magkos et al.   Nature Reviews Endocrinology

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

(2020) Alexandra Chadt et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Specific deletion of CDC42 in pancreatic β cells attenuates glucose-induced insulin expression and secretion in mice

(2020) Xiang-Qin He et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nucleocytoplasmic transport

(2019) Eduardo E. Benarroch   NEUROLOGY

The Ras Superfamily of Small GTPases in Non-neoplastic Cerebral Diseases

(2019) Liang Qu et al.   Frontiers in Molecular Neuroscience

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

(2019) Sean R. Jesinkey et al.   Cell Reports

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Lipid-associated metabolic signalling networks in pancreatic beta cell function

(2019) Marc Prentki et al.   DIABETOLOGIA

β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes

(2019) Laura I. Hudish et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

(2019) Toma-Fukai et al.   MOLECULES

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling

(2019) Jing Duan et al.   International Journal of Endocrinology

Regulation of Rho GTPases by RhoGDIs in Human Cancers

(2019) Cho et al.   Cells

Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion

(2018) Hee Jun Cho et al.   CANCER LETTERS

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

(2018) Nikhil R. Gandasi et al.   Cell Metabolism

Caveolin-1 deficiency protects pancreatic β cells against palmitate-induced dysfunction and apoptosis

(2018) Wen Zeng et al.   CELLULAR SIGNALLING

Restoration of Glucose-Stimulated Cdc42-Pak1 Activation and Insulin Secretion by a Selective Epac Activator in Type 2 Diabetic Human Islets

(2018) Rajakrishnan Veluthakal et al.   DIABETES

Novel approaches to restore beta cell function in prediabetes and type 2 diabetes

(2018) Vishal A. Salunkhe et al.   DIABETOLOGIA

The Science of Obesity Management: An Endocrine Society Scientific Statement

(2018) George A Bray et al.   ENDOCRINE REVIEWS

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner

(2018) Yanqing Zhang et al.   DIABETES

NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease

(2017) Radhika Rastogi et al.   Frontiers in Cellular Neuroscience

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

(2017) Fatou K. Ndiaye et al.   Molecular Metabolism

Type 1 diabetes mellitus

(2017) Anastasia Katsarou et al.   Nature Reviews Disease Primers

NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model

(2016) Rajakrishnan Veluthakal et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2

(2016) Kohichi Matsunaga et al.   JOURNAL OF CELL SCIENCE

A lack of ‘glue’ misplaces Rab27A to cause islet dysfunction in diabetes

(2016) Anjaneyulu Kowluru   JOURNAL OF PATHOLOGY

Protein prenylation: unique fats make their mark on biology

(2016) Mei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

(2016) Kyle S. McCommis et al.   Molecular Metabolism

The skeleton in the closet: actin cytoskeletal remodeling in β-cell function

(2015) Caroline Arous et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1)

(2015) Vaibhav Sidarala et al.   BIOCHEMICAL PHARMACOLOGY

Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells

(2015) Sergio Wehinger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells

(2015) Rajakrishnan Veluthakal et al.   DIABETOLOGIA

Increased risk of diabetes with statin treatment is associated with impaired insulin sensitivity and insulin secretion: a 6 year follow-up study of the METSIM cohort

(2015) Henna Cederberg et al.   DIABETOLOGIA

PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a

(2015) Mami Yamaoka et al.   JOURNAL OF CELL SCIENCE

GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation

(2015) Shan Jiang et al.   JOURNAL OF PATHOLOGY

Involvement of RhoA/ROCK in insulin secretion of pancreatic β-cells in 3D culture

(2014) Xiaofang Liu et al.   CELL AND TISSUE RESEARCH

YES, a Src Family Kinase, Is a Proximal Glucose-specific Activator of Cell Division Cycle Control Protein 42 (Cdc42) in Pancreatic Islet β Cells

(2014) Stephanie M. Yoder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arfs at a Glance

(2014) C. L. Jackson et al.   JOURNAL OF CELL SCIENCE

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

(2014) Ida Moltke et al.   NATURE

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion

(2014) Ghupurjan Gheni et al.   Cell Reports

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

Identification and Characterization of GLP-1 Receptor-Expressing Cells Using a New Transgenic Mouse Model

(2013) P. Richards et al.   DIABETES

Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin

(2013) S. Asahara et al.   DIABETOLOGIA

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

(2013) Maho Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling

(2013) Maria Eugenia Sabbatini et al.   PLoS One

Correction: The GTPase Rab37 Participates in the Control of Insulin Exocytosis

(2013) Sanda Ljubicic et al.   PLoS One

Regulation of Insulin Secretion in Human Pancreatic Islets

(2012) Patrik Rorsman et al.   Annual Review of Physiology

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Regulation of RhoA Signaling by the cAMP-dependent Phosphorylation of RhoGDIα

(2012) Atsuro Oishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane

(2012) Hao Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells

(2012) Daleep K. Arora et al.   Islets

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems

(2012) Josep M. Mercader et al.   PLoS Genetics

RhoB Loss Prevents Streptozotocin-Induced Diabetes and Ameliorates Diabetic Complications in Mice

(2011) Arturo Bravo-Nuevo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

(2011) Erica M. Kepner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

(2011) Nicolai M. Doliba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation

(2011) Ismail Syed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets

(2011) Bhavaani Jayaram et al.   BIOCHEMICAL PHARMACOLOGY

Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets

(2011) Ismail Syed et al.   DIABETES

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

(2011) Susumu Seino et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

(2011) Igor Dzhura et al.   Islets

Mapping Dynamic Protein Interactions to Insulin Secretory Granule Behavior with TIRF-FRET

(2010) Alice D. Lam et al.   BIOPHYSICAL JOURNAL

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor a with the small GTPase Rac

(2010) Fei Fei et al.   BMC BIOCHEMISTRY

Small G Proteins in Islet β-Cell Function

(2010) Anjaneyulu Kowluru   ENDOCRINE REVIEWS

Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic β cells

(2010) Wei-na Ma et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans

(2010) Joshua P. Lewis et al.   GENOMICS

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion

(2010) Athanassios Dovas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rap1 Promotes Multiple Pancreatic Islet Cell Functions and Signals through Mammalian Target of Rapamycin Complex 1 to Enhance Proliferation

(2010) Patrick Kelly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epac2-dependent mobilization of intracellular Ca2+by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ɛ knockout mice

(2010) Igor Dzhura et al.   JOURNAL OF PHYSIOLOGY-LONDON

Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials

(2010) Naveed Sattar et al.   LANCET

Glucose activates prenyltransferases in pancreatic islet β-cells

(2009) Marc Goalstone et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rac1 regulates pancreatic islet morphogenesis

(2009) Thomas U Greiner et al.   BMC DEVELOPMENTAL BIOLOGY

Statin Therapy and Risk of Developing Type 2 Diabetes: A Meta-Analysis

(2009) S. N. Rajpathak et al.   DIABETES CARE

Phosphoenolpyruvate Cycling via Mitochondrial Phosphoenolpyruvate Carboxykinase Links Anaplerosis and Mitochondrial GTP with Insulin Secretion

(2009) Romana Stark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Phosphorylation of RhoGDI Mediates the Distinct Cycling of Cdc42 and Rac1 to Regulate Second-phase Insulin Secretion

(2009) Zhanxiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology

(2009) T. McAvoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic β-cells

(2008) Rajakrishnan Veluthakal et al.   BIOCHEMICAL PHARMACOLOGY

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic  -Cells

(2008) K. Bouzakri et al.   DIABETES

R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians

(2008) Yvonne Böttcher et al.   JOURNAL OF HUMAN GENETICS

Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic β-cells

(2008) Matthew J. Merrins et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE