Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

Rapgef2 Connects GPCR-Mediated cAMP Signals to ERK Activation in Neuronal and Endocrine Cells

(2013) A. C. Emery et al.   Science Signaling

A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer

(2012) Jyotsana Menon et al.   PLoS One

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells

(2011) Pablo Hernández-Varas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1

(2011) Monika Raab et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ezrin is required for efficient Rap1-induced cell spreading

(2011) S. H. Ross et al.   JOURNAL OF CELL SCIENCE

The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge

(2011) Y. He et al.   JOURNAL OF CELL SCIENCE

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

Protein Kinase A Activity and Anchoring Are Required for Ovarian Cancer Cell Migration and Invasion

(2011) Andrew J. McKenzie et al.   PLoS One

Preventing the Activation or Cycling of the Rap1 GTPase Alters Adhesion and Cytoskeletal Dynamics and Blocks Metastatic Melanoma Cell Extravasation into the Lungs

(2010) Spencer A. Freeman et al.   CANCER RESEARCH

T Cell Receptor “Inside-Out” Pathway via Signaling Module SKAP1-RapL Regulates T Cell Motility and Interactions in Lymph Nodes

(2010) Monika Raab et al.   IMMUNITY

The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope

(2010) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Epac inhibits migration and proliferation of human prostate carcinoma cells

(2009) M Grandoch et al.   BRITISH JOURNAL OF CANCER

Control of cell adhesion dynamics by Rap1 signaling

(2009) Benjamin Boettner et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphorylation-induced Conformational Changes in Rap1b

(2009) Martin M. Edreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Asymmetric focal adhesion disassembly in motile cells

(2008) Joshua A Broussard et al.   CURRENT OPINION IN CELL BIOLOGY

Spatial Distribution of Protein Kinase A Activity during Cell Migration Is Mediated by A-kinase Anchoring Protein AKAP Lbc

(2008) Adriana A. Paulucci-Holthauzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

(2008) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Integrin-mediated Protein Kinase A Activation at the Leading Edge of Migrating Cells

(2008) Chinten J. Lim et al.   MOLECULAR BIOLOGY OF THE CELL

Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

(2007) George G. Holz et al.   CELLULAR SIGNALLING