Regulation of Rho GTPases by RhoGDIs in Human Cancers

Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression

(2019) Gui-fang Zhu et al.   Nature Communications

HER2 Upregulates ATF4 to Promote Cell Migration via Activation of ZEB1 and Downregulation of E-Cadherin

(2019) Peng Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Morin Hydrate Reverses Cisplatin Resistance by Impairing PARP1/HMGB1-Dependent Autophagy in Hepatocellular Carcinoma

(2019) Singh et al.   Cancers

RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling

(2019) Fan Dai et al.   ATHEROSCLEROSIS

Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion

(2018) Hee Jun Cho et al.   CANCER LETTERS

RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation

(2017) Jae-Gyu Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1

(2017) H J Cho et al.   ONCOGENE

NF-κB p65 Overexpression Promotes Bladder Cancer Cell Migration via FBW7-Mediated Degradation of RhoGDIα Protein

(2017) Junlan Zhu et al.   NEOPLASIA

RhoGDIα Acetylation at K127 and K141 Affects Binding toward Nonprenylated RhoA

(2016) Nora Kuhlmann et al.   BIOCHEMISTRY

An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression

(2016) Mansoor Ahmed et al.   CANCER CELL

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion

(2016) Xihua Lin et al.   Oncotarget

Activating Transcription Factor 4 (ATF4) modulates Rho GTPase levels and function via regulation of RhoGDIα

(2016) Silvia Pasini et al.   Scientific Reports

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases

(2016) Cameron Smithers et al.   Cells

Signaling, Regulation, and Specificity of the Type II p21-activated Kinases

(2015) Byung Hak Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation

(2015) Nora Kuhlmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Phosphatase-PEST and β8 Integrin Regulate Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells

(2015) Hye Shin Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1

(2015) Congren Wang et al.   Oncotarget

Differentially Expressed Proteins in ER+MCF7 and ER-MDA-MB-231 Human Breast Cancer Cells by RhoGDI-α Silencing and Overexpression

(2014) Somayeh Hooshmand et al.   Asian Pacific Journal of Cancer Prevention

miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM

(2014) Q. Song et al.   CANCER RESEARCH

VEGF-C mediates RhoGDI2-induced gastric cancer cell metastasis and cisplatin resistance

(2014) Hee Jun Cho et al.   INTERNATIONAL JOURNAL OF CANCER

14-3-3  Promotes Breast Cancer Invasion and Metastasis by Inhibiting RhoGDI 

(2014) Y. Xiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma

(2013) Hui Wang et al.   FEBS LETTERS

TROY Interacts with Rho Guanine Nucleotide Dissociation Inhibitor α (RhoGDIα) to Mediate Nogo-induced Inhibition of Neurite Outgrowth

(2013) Yan Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation of RhoGDIα is required for its repression of cyclin D1 expression and anchorage-independent growth of cancer cells

(2013) Zipeng Cao et al.   Molecular Oncology

Cholecystokinin-Mediated RhoGDI Phosphorylation via PKCα Promotes both RhoA and Rac1 Signaling

(2013) Maria Eugenia Sabbatini et al.   PLoS One

FERM Domain Containing Protein 7 Interacts with the Rho GDP Dissociation Inhibitor and Specifically Activates Rac1 Signaling

(2013) Jiali Pu et al.   PLoS One

Downregulation of RhoGDIα increased migration and invasion of ER+MCF7 and ER−MDA-MB-231 breast cancer cells

(2013) Somayeh Hooshmand et al.   Cell Adhesion & Migration

RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility

(2012) Jianxiu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of RhoA Signaling by the cAMP-dependent Phosphorylation of RhoGDIα

(2012) Atsuro Oishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoGDI2 confers gastric cancer cells resistance against cisplatin-induced apoptosis by upregulation of Bcl-2 expression

(2011) Hee Jun Cho et al.   CANCER LETTERS

Protein kinase A governs a RhoA–RhoGDI protrusion–retraction pacemaker in migrating cells

(2011) Eugene Tkachenko et al.   NATURE CELL BIOLOGY

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor a with the small GTPase Rac

(2010) Fei Fei et al.   BMC BIOCHEMISTRY

RhoGDI signaling provides targets for cancer therapy

(2010) Michael A. Harding et al.   EUROPEAN JOURNAL OF CANCER

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion

(2010) Athanassios Dovas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

(2010) Etienne Boulter et al.   NATURE CELL BIOLOGY

Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA

(2010) Jie Ding et al.   NATURE CELL BIOLOGY

Diacylglycerol kinase   mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI

(2010) F. Chianale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RhoGDI2 Expression Is Associated with Tumor Growth and Malignant Progression of Gastric Cancer

(2009) H. J. Cho et al.   CLINICAL CANCER RESEARCH

RhoGDI2 as a therapeutic target in cancer

(2009) Hee Jun Cho et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Diacylglycerol Kinase ζ Regulates Actin Cytoskeleton Reorganization through Dissociation of Rac1 from RhoGDI

(2009) Hanan Abramovici et al.   MOLECULAR BIOLOGY OF THE CELL

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

Overexpression of Rho GDP-Dissociation Inhibitor Alpha Is Associated with Tumor Progression and Poor Prognosis of Colorectal Cancer

(2008) Liang Zhao et al.   JOURNAL OF PROTEOME RESEARCH