- Home
- Publications
- Publication Search
- Publication Details
Title
Arginine Signaling and Cancer Metabolism
Authors
Keywords
-
Journal
Cancers
Volume 13, Issue 14, Pages 3541
Publisher
MDPI AG
Online
2021-07-15
DOI
10.3390/cancers13143541
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Arginine Deiminase Induces Immunogenic Cell Death and Is Enhanced by N-acetylcysteine in Murine MC38 Colorectal Cancer Cells and MDA-MB-231 Human Breast Cancer Cells In Vitro
- (2021) Zhiying Huang et al. MOLECULES
- Phase 1 trial of ADI-PEG20 plus cisplatin in patients with pretreated metastatic melanoma or other advanced solid malignancies
- (2021) Shuyang Yao et al. BRITISH JOURNAL OF CANCER
- Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells
- (2021) Chia-Lin Chen et al. Nature Communications
- Phase I study of ADI‐PEG20 plus low‐dose cytarabine for the treatment of acute myeloid leukemia
- (2021) Hui‐Jen Tsai et al. Cancer Medicine
- Knockdown of SLCO4C1 inhibits cell proliferation and metastasis in endometrial cancer through inactivating the PI3K/Akt signaling pathway
- (2020) Xiang Hu et al. ONCOLOGY REPORTS
- Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
- (2020) Erika M. Palmieri et al. Nature Communications
- Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase deficient ovarian cancer, including small cell carcinoma of the ovary, hypercalcemic type
- (2020) Jennifer X Ji et al. CLINICAL CANCER RESEARCH
- Myeloid Cell-Derived Arginase in Cancer Immune Response
- (2020) Tomasz M. Grzywa et al. Frontiers in Immunology
- Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy
- (2020) Qingyuan Feng et al. BMC CANCER
- Phase II Study of Arginine Deprivation Therapy with Pegargiminase in Patients with Relapsed Sensitive or Refractory Small Cell Lung Cancer.
- (2020) Peter E. Hall et al. Clinical Lung Cancer
- Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
- (2020) Weimin Wang et al. MOLECULAR CELL
- Systems level profiling of arginine starvation reveals MYC and ERK adaptive metabolic reprogramming
- (2020) Caitlyn B. Brashears et al. Cell Death & Disease
- Transport of L-Arginine Related Cardiovascular Risk Markers
- (2020) Sofna Banjarnahor et al. Journal of Clinical Medicine
- Promotion of homology-directed DNA repair by polyamines
- (2019) Chih-Ying Lee et al. Nature Communications
- p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake
- (2019) Xazmin H. Lowman et al. Cell Reports
- A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma
- (2019) Peter E. Hall et al. CLINICAL CANCER RESEARCH
- Arginine Starvation and Docetaxel Induce c-Myc-Driven hENT1 Surface Expression to Overcome Gemcitabine Resistance in ASS1-Negative Tumors
- (2019) Bethany C Prudner et al. CLINICAL CANCER RESEARCH
- MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion
- (2019) Milind D. Chalishazar et al. CLINICAL CANCER RESEARCH
- DNA double-strand break repair-pathway choice in somatic mammalian cells
- (2019) Ralph Scully et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities
- (2019) Weilei Hu et al. Frontiers in Immunology
- Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation
- (2019) Pankaj K. Singh et al. MOLECULAR CANCER THERAPEUTICS
- TSC1/mTOR-controlled metabolic–epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis
- (2019) Lei Shi et al. PLOS BIOLOGY
- Arginine metabolism and deprivation in cancer therapy
- (2019) Songyun Zou et al. BIOMEDICINE & PHARMACOTHERAPY
- Targeting extracellular nutrient dependencies of cancer cells
- (2019) Javier Garcia-Bermudez et al. Molecular Metabolism
- Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability
- (2019) Anke Werner et al. Frontiers in Oncology
- [HuArgI (co)-PEG5000]-induced arginine deprivation leads to autophagy dependent cell death in pancreatic cancer cells
- (2019) Nathalie Khalil et al. INVESTIGATIONAL NEW DRUGS
- Arginine deprivation inhibits pancreatic cancer cell migration, invasion and EMT via the down regulation of Snail, Slug, Twist, and MMP1/9
- (2019) Huan Wang et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors
- (2019) Macus Tien Kuo et al. Translational Oncology
- Phase III randomized study of second line ADI-PEG 20 plus best supportive care versus placebo plus best supportive care in patients with advanced hepatocellular carcinoma
- (2018) G K Abou-Alfa et al. ANNALS OF ONCOLOGY
- A phase 1 study of ADI-PEG 20 and modified FOLFOX6 in patients with advanced hepatocellular carcinoma and other gastrointestinal malignancies
- (2018) James J. Harding et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma
- (2018) Carmela De Santo et al. Journal of Hematology & Oncology
- Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI‑PEG20 treatment in CCA cell lines
- (2018) Somphon Roeksomtawin et al. Oncology Letters
- Arginine and the metabolic regulation of nitric oxide synthesis in cancer
- (2018) Rom Keshet et al. Disease Models & Mechanisms
- Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
- (2018) Constantinos Alexandrou et al. Scientific Reports
- Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
- (2018) Austin Yeon et al. Theranostics
- Autophagy maintains tumour growth through circulating arginine
- (2018) Laura Poillet-Perez et al. NATURE
- Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM
- (2018) Justyna Magdalena Przystal et al. Cell Death & Disease
- The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma
- (2017) Angkana Thongkum et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Phase 1 Dose-Escalation Study of Pegylated Arginine Deiminase, Cisplatin, and Pemetrexed in Patients With Argininosuccinate Synthetase 1–Deficient Thoracic Cancers
- (2017) Emma Beddowes et al. JOURNAL OF CLINICAL ONCOLOGY
- Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency
- (2017) Hui Jiang et al. Oncotarget
- PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration
- (2017) Elena Brin et al. Oncotarget
- Optimizing arginine deprivation for hard-to-treat cancers
- (2017) Ramsay Khadeir et al. Oncotarget
- Hepatitis B virus X protein-induced upregulation of CAT-1 stimulates proliferation and inhibits apoptosis in hepatocellular carcinoma cells
- (2017) Rongjuan Dai et al. Oncotarget
- Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways
- (2017) Pablo Garrido et al. Oncotarget
- Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis
- (2017) Yang Jiang et al. Theranostics
- Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
- (2017) Jeff Charles Kremer et al. Cell Reports
- Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression
- (2017) Anke Werner et al. Frontiers in Immunology
- GPRC6A: Jack of all metabolism (or master of none)
- (2017) Min Pi et al. Molecular Metabolism
- Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1–Deficient Malignant Pleural Mesothelioma
- (2017) Peter W. Szlosarek et al. JAMA Oncology
- Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53
- (2017) Takafumi Miyamoto et al. Science Advances
- Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
- (2017) Susanne M. Steggerda et al. Journal for ImmunoTherapy of Cancer
- Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression
- (2017) Wen-Bin Tsai et al. Scientific Reports
- A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients
- (2017) Hui-Jen Tsai et al. Scientific Reports
- Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
- (2016) C.-T. Cheng et al. CANCER RESEARCH
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
- (2016) Lynne Chantranupong et al. CELL
- Arginine Arms T Cells to Thrive and Survive
- (2016) Rigel J. Kishton et al. Cell Metabolism
- SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate
- (2016) Chi Chun Wong et al. GASTROENTEROLOGY
- Molecular basis and current strategies of therapeutic arginine depletion for cancer
- (2016) Livingstone Fultang et al. INTERNATIONAL JOURNAL OF CANCER
- Functions of Polyamines in Mammals
- (2016) Anthony E. Pegg JOURNAL OF BIOLOGICAL CHEMISTRY
- Arginine dependence of tumor cells: targeting a chink in cancer’s armor
- (2016) M D Patil et al. ONCOGENE
- A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas
- (2016) Gregory R Bean et al. Cell Death & Disease
- Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival
- (2016) Edoardo Gaude et al. Nature Communications
- Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation
- (2016) Yan Long et al. Oncotarget
- Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1
- (2016) Matthew Locke et al. Cell Reports
- TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection
- (2016) Ulrike Schleicher et al. Cell Reports
- Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages
- (2016) Jan Van den Bossche et al. Cell Reports
- Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
- (2016) Bernadette Carroll et al. eLife
- Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20)
- (2016) Natalie Burrows et al. Scientific Reports
- Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer
- (2015) Ellappan Babu et al. BIOCHEMICAL JOURNAL
- Phase I Trial of Arginine Deprivation Therapy with ADI-PEG 20 Plus Docetaxel in Patients with Advanced Malignant Solid Tumors
- (2015) B. K. Tomlinson et al. CLINICAL CANCER RESEARCH
- Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation
- (2015) Anke Werner et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Preliminary efficacy, safety, pharmacokinetics, pharmacodynamics and quality of life study of pegylated recombinant human arginase 1 in patients with advanced hepatocellular carcinoma
- (2015) Thomas Yau et al. INVESTIGATIONAL NEW DRUGS
- Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
- (2015) Shiran Rabinovich et al. NATURE
- Metabolic pathways promoting cancer cell survival and growth
- (2015) Lindsey K. Boroughs et al. NATURE CELL BIOLOGY
- Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents
- (2015) W-B Tsai et al. ONCOGENE
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas
- (2015) María Laura Gutiérrez et al. Oncotarget
- Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin
- (2015) Niramol Savaraj et al. Oncotarget
- Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy
- (2014) Jennifer A McAlpine et al. BMC CANCER
- Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2
- (2014) E. Lopez-Rivera et al. CANCER RESEARCH
- Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
- (2014) Rouzbeh Daylami et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- L-Arginine Stimulates Fibroblast Proliferation through the GPRC6A-ERK1/2 and PI3K/Akt Pathway
- (2014) Takashi Fujiwara et al. PLoS One
- Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy
- (2014) Chun A. Changou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells
- (2014) F. Qiu et al. Science Signaling
- Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages
- (2014) Meera Rath et al. Frontiers in Immunology
- ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
- (2013) H.-Y. Huang et al. CLINICAL CANCER RESEARCH
- Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence, and Glutamine Addiction
- (2013) Yan Long et al. MOLECULAR CANCER THERAPEUTICS
- Amino acid signalling upstream of mTOR
- (2013) Jenna L. Jewell et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Overexpression of Arginine Transporter CAT-1 Is Associated with Accumulation of L-Arginine and Cell Growth in Human Colorectal Cancer Tissue
- (2013) Ying Lu et al. PLoS One
- Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
- (2013) I. Ben-Sahra et al. SCIENCE
- Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
- (2013) A. M. Robitaille et al. SCIENCE
- Nutrient signaling to mTOR and cell growth
- (2013) Jenna L. Jewell et al. TRENDS IN BIOCHEMICAL SCIENCES
- Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma
- (2013) N Syed et al. Cell Death & Disease
- Autophagy
- (2012) Tsung-Chin Lin et al. Autophagy
- Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase
- (2012) L G Feun et al. BRITISH JOURNAL OF CANCER
- Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells
- (2012) W.-B. Tsai et al. CANCER RESEARCH
- A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma
- (2012) Thomas Yau et al. INVESTIGATIONAL NEW DRUGS
- Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma
- (2012) Patrick A. Ott et al. INVESTIGATIONAL NEW DRUGS
- TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation
- (2012) Min You et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Arginine deprivation as a new treatment strategy for head and neck cancer
- (2012) Cheng-Chih Huang et al. ORAL ONCOLOGY
- Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis
- (2012) B Delage et al. Cell Death & Disease
- Cytotoxicity of human recombinant arginase I (Co)-PEG5000 in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells
- (2011) Vaidehi Agrawal et al. ANTI-CANCER DRUGS
- Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase
- (2011) M P Kelly et al. BRITISH JOURNAL OF CANCER
- CAT-1-mediated arginine uptake and regulation of nitric oxide synthases for the survival of human breast cancer cell lines
- (2011) Salma A. Abdelmagid et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Immune Evasion by Helicobacter pylori Is Mediated by Induction of Macrophage Arginase II
- (2011) N. D. Lewis et al. JOURNAL OF IMMUNOLOGY
- l-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells
- (2011) Xiangfeng Kong et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- GPRC6A regulates prostate cancer progression
- (2011) Min Pi et al. PROSTATE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer
- (2010) Barbara Delage et al. INTERNATIONAL JOURNAL OF CANCER
- Arginine: Master and Commander in Innate Immune Responses
- (2010) S. M. Morris Science Signaling
- Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling
- (2010) J. E. Qualls et al. Science Signaling
- Amino acids: metabolism, functions, and nutrition
- (2009) Guoyao Wu AMINO ACIDS
- Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis
- (2009) R. H. Kim et al. CANCER RESEARCH
- Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1 /Sp4
- (2009) W.-B. Tsai et al. MOLECULAR CANCER THERAPEUTICS
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Myeloid-Derived Suppressor Cells Promote Cross-Tolerance in B-Cell Lymphoma by Expanding Regulatory T Cells
- (2008) P. Serafini et al. CANCER RESEARCH
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase
- (2008) Tawnya L. Bowles et al. INTERNATIONAL JOURNAL OF CANCER
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now