Journal
ONCOTARGET
Volume 8, Issue 37, Pages 60962-60974Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.17631
Keywords
HBx; CAT-1; miR-122; Gld2; HCC
Categories
Funding
- National Natural Science Fund of China [81370542]
- Chinese National Key Clinical Specialty Project [2013]
- Chinese National Science and Technology Major Project [2008ZX10202]
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The HBx protein of hepatitis B virus (HBV) is widely recognized to be a critical oncoprotein contributing to the development of HBV-related hepatocellular carcinoma (HCC). In addition, cationic amino acid transporter 1 (CAT-1) gene is a target of miR-122. In this study, we found that CAT-1 protein levels were higher in HBV-related HCC carcinomatous tissues than in para-cancerous tumor tissues, and that CAT-1 promoted HCC cell growth, proliferation, and metastasis. Moreover, HBx-induced decreases in Gld2 and miR-122 levels that contributed to the upregulation of CAT-1 in HCC. These results indicate that a Gld2/miR-122/CAT-1 pathway regulated by HBx likely participates in HBV-related hepatocellular carcinogenesis.
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