Arginine is an epigenetic regulator targeting TEAD4 to modulate OXPHOS in prostate cancer cells

OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

(2020) Bernd Schöpf et al.   Nature Communications

A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma

(2019) Peter E. Hall et al.   CLINICAL CANCER RESEARCH

Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression

(2019) Lingli He et al.   CANCER RESEARCH

Regulation of TEAD Transcription Factors in Cancer Biology

(2019) Hyunbin D. Huh et al.   Cells

O-Glycosylation–mediated signaling circuit drives metastatic castration-resistant prostate cancer

(2018) Sheue-Fen Tzeng et al.   FASEB JOURNAL

Regulation of energy metabolism during early mammalian development: TEAD4 controls mitochondrial transcription

(2018) Ram P. Kumar et al.   DEVELOPMENT

Functions and mechanisms of non-histone protein acetylation

(2018) Takeo Narita et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficacy of arginine depletion by ADI-PEG20 in an intracranial model of GBM

(2018) Justyna Magdalena Przystal et al.   Cell Death & Disease

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

(2017) Kimberly C. Lin et al.   NATURE CELL BIOLOGY

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

(2017) Shi Jiao et al.   Nature Communications

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

(2017) Jeff Charles Kremer et al.   Cell Reports

Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1–Deficient Malignant Pleural Mesothelioma

(2017) Peter W. Szlosarek et al.   JAMA Oncology

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma

(2016) Ying-Ying Li et al.   Oncotarget

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

(2016) Anthony J Covarrubias et al.   eLife

Chromatophagy: Autophagy goes nuclear and captures broken chromatin during arginine-starvation

(2015) Hsing-Jien Kung et al.   Autophagy

EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer

(2015) Jing Zhang et al.   EMBO JOURNAL

Genetic variants in Hippo pathway genesYAP1,TEAD1andTEAD4are associated with melanoma-specific survival

(2015) Hua Yuan et al.   INTERNATIONAL JOURNAL OF CANCER

Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial–mesenchymal transition and metastasis in a YAP-independent manner

(2015) Y Liu et al.   ONCOGENE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

(2015) Niramol Savaraj et al.   Oncotarget

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

(2014) Chun A. Changou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells

(2014) F. Qiu et al.   Science Signaling

TEAD4 establishes the energy homeostasis essential for blastocoel formation

(2013) K. J. Kaneko et al.   DEVELOPMENT

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis

(2012) B Delage et al.   Cell Death & Disease

Structural basis of YAP recognition by TEAD4 in the Hippo pathway

(2010) L. Chen et al.   GENES & DEVELOPMENT

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT