A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

Soft Tissue Sarcoma, Version 2.2014

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Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Programmed necrosis and necroptosis signalling

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Drugging the p53 pathway: understanding the route to clinical efficacy

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Arginine deprivation and autophagic cell death in cancer

(2014) Peter Wojciech Szlosarek   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

(2014) Chun A. Changou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine Starvation Impairs Mitochondrial Respiratory Function in ASS1-Deficient Breast Cancer Cells

(2014) F. Qiu et al.   Science Signaling

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging

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ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance

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Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

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Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma

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Novel Pathways and Molecular Targets for the Treatment of Sarcoma

(2013) Ashley E. Frith et al.   Current Oncology Reports

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase

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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma

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TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

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Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase

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Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

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Arginine Deprivation, Autophagy, Apoptosis (AAA) for the Treatment of Melanoma

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Phase II Study of Pegylated Arginine Deiminase for Nonresectable and Metastatic Hepatocellular Carcinoma

(2010) Evan S. Glazer et al.   JOURNAL OF CLINICAL ONCOLOGY

Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma

(2010) E. Kobayashi et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer

(2009) Linda J. Nicholson et al.   INTERNATIONAL JOURNAL OF CANCER

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

Mutations and polymorphisms in the human argininosuccinate synthetase (ASS1) gene

(2008) Katharina Engel et al.   HUMAN MUTATION

Pancreatic cancer cell lines deficient in argininosuccinate synthetase are sensitive to arginine deprivation by arginine deiminase

(2008) Tawnya L. Bowles et al.   INTERNATIONAL JOURNAL OF CANCER