Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients

(2021) Maria Xydia et al.   Nature Communications

New predictors for immunotherapy responses sharpen our view of the tumour microenvironment

(2020) Tullia C. Bruno   NATURE

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

(2020) Yaqing Zhang et al.   Cancer Discovery

TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer

(2020) Ksenia M. Yegodayev et al.   Cancers

Tumor-infiltrating regulatory T cells, CD8/Treg ratio, and cancer stem cells are correlated with lymph node metastasis in patients with early breast cancer

(2020) Luis Alberto Solis-Castillo et al.   Breast Cancer

Mogamulizumab in Combination with Durvalumab or Tremelimumab in Patients with Advanced Solid Tumors: A Phase I Study

(2020) Dmitriy Zamarin et al.   CLINICAL CANCER RESEARCH

Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy

(2020) Christopher A Chuckran et al.   Journal for ImmunoTherapy of Cancer

HIF-2α is indispensable for regulatory T cell function

(2020) Tzu-Sheng Hsu et al.   Nature Communications

TIGIT in cancer immunotherapy

(2020) Joe-Marc Chauvin et al.   Journal for ImmunoTherapy of Cancer

Collagen density regulates the activity of tumor-infiltrating T cells

(2019) Dorota E. Kuczek et al.   Journal for ImmunoTherapy of Cancer

Umbilical cord blood‑derived Helios‑positive regulatory T�cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway

(2019) Xue Li et al.   Molecular Medicine Reports

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion

(2019) Deepali V. Sawant et al.   NATURE IMMUNOLOGY

Targeting Treg cells in cancer immunotherapy

(2019) Atsushi Tanaka et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A positive feedback between IDO1 metabolite and COL12A1 via MAPK pathway to promote gastric cancer metastasis

(2019) Zhen Xiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function

(2019) Selena Vigano et al.   Frontiers in Immunology

CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

(2019) Vitalijs Ovcinnikovs et al.   Science Immunology

A Phase I Study of the Anti-CC Chemokine Receptor 4 Antibody, Mogamulizumab, in Combination with Nivolumab in Patients with Advanced or Metastatic Solid Tumors

(2019) Toshihiko Doi et al.   CLINICAL CANCER RESEARCH

A neuropilin-1 antagonist exerts anti-tumor immunity by inhibiting the suppressive function of intratumoral regulatory T cells

(2019) Keunok Jung et al.   Cancer Immunology Research

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment

(2018) Rong Fu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

(2018) Fei Tang et al.   Cell and Bioscience

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity

(2018) Prabhakaran Kumar et al.   JOURNAL OF AUTOIMMUNITY

TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action

(2017) Wenwen Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phenotypic and Functional Properties of Tumor-Infiltrating Regulatory T Cells

(2017) Gap Ryol Lee   MEDIATORS OF INFLAMMATION

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

(2017) Shucai Yang et al.   Molecular Cancer

CCR5-Dependent Homing of T Regulatory Cells to the Tumor Microenvironment Contributes to Skin Squamous Cell Carcinoma Development

(2017) Carine Ervolino de Oliveira et al.   MOLECULAR CANCER THERAPEUTICS

The relative change in regulatory T cells / T helper lymphocytes ratio as parameter for prediction of therapy efficacy in metastatic colorectal cancer patients

(2017) Tong Xu et al.   Oncotarget

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

(2017) Leena Halim et al.   Cell Reports

Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

(2017) Emily J. Colbeck et al.   Cancer Immunology Research

The IDO–AhR Axis Controls Th17/Treg Immunity in a Pulmonary Model of Fungal Infection

(2017) Eliseu Frank de Araújo et al.   Frontiers in Immunology

Sunitinib represses regulatory T cells to overcome immunotolerance in a murine model of hepatocellular cancer

(2017) Dai Liu et al.   OncoImmunology

Efficacy and toxicity of treatment with the anti-CTLA-4 antibody ipilimumab in patients with metastatic melanoma after prior anti-PD-1 therapy

(2016) S Bowyer et al.   BRITISH JOURNAL OF CANCER

Interleukin-35 Limits Anti-Tumor Immunity

(2016) Meghan E. Turnis et al.   IMMUNITY

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

(2016) J-t Cheng et al.   Oncogenesis

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Regulatory T Cells Promote β-Catenin–Mediated Epithelium-to-Mesenchyme Transition During Radiation-Induced Pulmonary Fibrosis

(2015) Shanshan Xiong et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity

(2015) Alison M. Paterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

(2015) J. David Peske et al.   Nature Communications

Reduction of Regulatory T Cells by Mogamulizumab, a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients with Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome

(2014) X. Ni et al.   CLINICAL CANCER RESEARCH

Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II

(2014) Bitao Liang et al.   JOURNAL OF IMMUNOLOGY

Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

(2014) M. C. B. Tan et al.   JOURNAL OF IMMUNOLOGY

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Active CREB1 Promotes a Malignant TGF 2 Autocrine Loop in Glioblastoma

(2014) L. Rodon et al.   Cancer Discovery

Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

(2013) Tomonari Kinoshita et al.   CANCER SCIENCE

Tumor Stromal Architecture Can Define the Intrinsic Tumor Response to VEGF-Targeted Therapy

(2013) N. R. Smith et al.   CLINICAL CANCER RESEARCH

TGF-β Cytokine Signaling Promotes CD8+ T Cell Development and Low-Affinity CD4+ T Cell Homeostasis by Regulation of Interleukin-7 Receptor α Expression

(2013) Weiming Ouyang et al.   IMMUNITY

The VEGF receptor, neuropilin-1, represents a promising novel target for chronic lymphocytic leukemia patients

(2013) Agnieszka Piechnik et al.   INTERNATIONAL JOURNAL OF CANCER

Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy

(2013) Paula D. Bos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells

(2013) S. Malchow et al.   SCIENCE

Convergences and Divergences of Thymus- and Peripherally Derived Regulatory T Cells in Cancer

(2013) Alessia Burocchi et al.   Frontiers in Immunology

T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

(2012) J. P. Hindley et al.   CANCER RESEARCH

The T-cell Receptor Repertoire of Tumor-Infiltrating Regulatory T Lymphocytes Is Skewed Toward Public Sequences

(2012) A. Sainz-Perez et al.   CANCER RESEARCH

VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer

(2012) M. Terme et al.   CANCER RESEARCH

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

(2012) R. J. deLeeuw et al.   CLINICAL CANCER RESEARCH

Neuropilin 1 deficiency on CD4+Foxp3+regulatory T cells impairs mouse melanoma growth

(2012) Wiebke Hansen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-7 Influences FOXP3+CD4+ Regulatory T Cells Peripheral Homeostasis

(2012) Federico Simonetta et al.   PLoS One

CD8+ cytotoxic T cell and FOXP3+ regulatory T cell infiltration in relation to breast cancer survival and molecular subtypes

(2011) Fangfang Liu et al.   BREAST CANCER RESEARCH AND TREATMENT

Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types

(2011) Gang Wei et al.   IMMUNITY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Localization of FOXP3-positive cells in renal cell carcinoma

(2011) Katharina Sell et al.   TUMOR BIOLOGY

Tumor necrosis factor-α is associated with positive lymph node status in patients with recurrence of colorectal cancer—indications for anti-TNF-α agents in cancer treatment

(2011) M. Grimm et al.   CELLULAR ONCOLOGY

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

(2010) R. K. Shrimali et al.   CANCER RESEARCH

Analysis of the T-Cell Receptor Repertoires of Tumor-Infiltrating Conventional and Regulatory T Cells Reveals No Evidence for Conversion in Carcinogen-Induced Tumors

(2010) J. P. Hindley et al.   CANCER RESEARCH

Foxp3+ T Cells Induce Perforin-Dependent Dendritic Cell Death in Tumor-Draining Lymph Nodes

(2010) Alexandre Boissonnas et al.   IMMUNITY

The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation

(2009) P. Farinha et al.   BLOOD

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

Combination of peritumoral mast cells and T-regulatory cells predicts prognosis of hepatocellular carcinoma

(2009) Min-Jie Ju et al.   CANCER SCIENCE

Transforming Growth Factor-βs and Mammary Gland Involution; Functional Roles and Implications for Cancer Progression

(2009) Kathleen C. Flanders et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

The prognostic value of peritumoral regulatory T cells and its correlation with intratumoral cyclooxygenase-2 expression in clear cell renal cell carcinoma

(2008) Jin F. Li et al.   BJU INTERNATIONAL

Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma

(2008) A. Tzankov et al.   HAEMATOLOGICA

The T-cell receptor repertoire of regulatory T cells

(2008) Rafal Pacholczyk et al.   IMMUNOLOGY

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE