Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

Immune-Based Antitumor Effects of BRAF Inhibitors Rely on Signaling by CD40L and IFN 

(2014) P.-C. Ho et al.   CANCER RESEARCH

Activated CD8 T Cells Redistribute to Antigen-Free Lymph Nodes and Exhibit Effector and Memory Characteristics

(2014) C. C. Brinkman et al.   JOURNAL OF IMMUNOLOGY

Melanoma-intrinsic β-catenin signaling prevents T cell infiltration and anti-tumor immunity

(2014) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

Cognate antigen directs CD8+ T cell migration to vascularized transplants

(2013) Jeffrey M. Walch et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial cell–specific lymphotoxin-β receptor signaling is critical for lymph node and high endothelial venule formation

(2013) Lucas Onder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High Endothelial Venule Blood Vessels for Tumor-Infiltrating Lymphocytes Are Associated with Lymphotoxin  -Producing Dendritic Cells in Human Breast Cancer

(2013) L. Martinet et al.   JOURNAL OF IMMUNOLOGY

T-Cell Trafficking Facilitated by High Endothelial Venules Is Required for Tumor Control after Regulatory T-Cell Depletion

(2012) J. P. Hindley et al.   CANCER RESEARCH

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?

(2012) Jane L. Messina et al.   Scientific Reports

High endothelial venules (HEVs) in human melanoma lesions

(2012) Ludovic Martinet et al.   OncoImmunology

Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling

(2011) Domenico Coppola et al.   AMERICAN JOURNAL OF PATHOLOGY

β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient Melanomas

(2011) William E. Damsky et al.   CANCER CELL

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

(2011) A. Palazon et al.   CANCER RESEARCH

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

(2011) L. Martinet et al.   CANCER RESEARCH

Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses

(2011) Reza Motallebzadeh et al.   FASEB JOURNAL

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

(2011) Christine Moussion et al.   NATURE

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotoxin-dependent pathway

(2010) V. Kumar et al.   BLOOD

Natural Killer Cell Education and Tolerance

(2010) Mark T. Orr et al.   CELL

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus–infected mice

(2009) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells

(2009) Stephan Halle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice

(2009) Margaret K Gatumu et al.   ARTHRITIS RESEARCH & THERAPY

Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking

(2008) Hekla Sigmundsdottir et al.   NATURE IMMUNOLOGY