TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer
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Title
TGF-Beta-Activated Cancer-Associated Fibroblasts Limit Cetuximab Efficacy in Preclinical Models of Head and Neck Cancer
Authors
Keywords
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Journal
Cancers
Volume 12, Issue 2, Pages 339
Publisher
MDPI AG
Online
2020-02-06
DOI
10.3390/cancers12020339
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Note: Only part of the references are listed.- MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer
- (2019) Ofra Novoplansky et al. INTERNATIONAL JOURNAL OF CANCER
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- (2019) Andrew Woolston et al. CANCER CELL
- Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma
- (2019) Li‑Ping Sun et al. ONCOLOGY REPORTS
- Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells
- (2019) Jose M. Ayuso et al. Scientific Reports
- BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC
- (2018) Brandon Leonard et al. CANCER RESEARCH
- Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts
- (2018) Delfina Costa et al. Frontiers in Immunology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Transforming growth factor‑β signaling in head and neck squamous cell carcinoma: Insights into cellular responses (Review)
- (2018) Xin Pang et al. Oncology Letters
- The roles of PTEN, cMET, and p16 in resistance to cetuximab in head and neck squamous cell carcinoma
- (2018) Alexandre A. B. A. da Costa et al. MEDICAL ONCOLOGY
- HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models
- (2016) Dongsheng Wang et al. CLINICAL CANCER RESEARCH
- Functional Genomics Uncover the Biology behind the Responsiveness of Head and Neck Squamous Cell Cancer Patients to Cetuximab
- (2016) P. Bossi et al. CLINICAL CANCER RESEARCH
- Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma
- (2016) Paolo Bossi et al. Oncotarget
- AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas
- (2015) Moshe Elkabets et al. CANCER CELL
- Microenvironmental regulation of therapeutic response in cancer
- (2015) Florian Klemm et al. TRENDS IN CELL BIOLOGY
- Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer
- (2015) Sandra Schmitz et al. Oncotarget
- Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids
- (2015) Stephan Klöss et al. Frontiers in Immunology
- Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth
- (2015) Kazuyoshi Shiga et al. Cancers
- AXL Mediates Resistance to Cetuximab Therapy
- (2014) T. M. Brand et al. CANCER RESEARCH
- Podoplanin-Positive Cancer-Associated Fibroblasts in the Tumor Microenvironment Induce Primary Resistance to EGFR-TKIs in Lung Adenocarcinoma with EGFR Mutation
- (2014) Tatsuya Yoshida et al. CLINICAL CANCER RESEARCH
- TGF-beta in CAF-mediated tumor growth and metastasis
- (2014) A. Calon et al. SEMINARS IN CANCER BIOLOGY
- Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models
- (2013) Sarah Elizabeth Wheeler et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance
- (2013) C. Boeckx et al. ONCOLOGIST
- Molecular communication between tumor-associated fibroblasts and head and neck squamous cell carcinoma
- (2013) George Leef et al. ORAL ONCOLOGY
- RNA-Seq Differentiates Tumour and Host mRNA Expression Changes Induced by Treatment of Human Tumour Xenografts with the VEGFR Tyrosine Kinase Inhibitor Cediranib
- (2013) James R. Bradford et al. PLoS One
- Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase-Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells
- (2012) A.-C. Johansson et al. MOLECULAR CANCER RESEARCH
- Inhibition of TGF- Enhances the In Vivo Antitumor Efficacy of EGF Receptor-Targeted Therapy
- (2012) A. Bedi et al. MOLECULAR CANCER THERAPEUTICS
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Phase II study of the combination of cetuximab and weekly paclitaxel in the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
- (2011) R. Hitt et al. ANNALS OF ONCOLOGY
- Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion
- (2011) Yuan Zhang et al. CANCER LETTERS
- Expression of Amphiregulin and EGFRvIII Affect Outcome of Patients with Squamous Cell Carcinoma of the Head and Neck Receiving Cetuximab-Docetaxel Treatment
- (2011) I. Tinhofer et al. CLINICAL CANCER RESEARCH
- Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer
- (2011) Tadaaki Yamada et al. Journal of Thoracic Oncology
- Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
- (2011) Mina J Bissell et al. NATURE MEDICINE
- TGF- downregulates the activating receptor NKG2D on NK cells and CD8+ T cells in glioma patients
- (2011) C. A. Crane et al. NEURO-ONCOLOGY
- Cetuximab Therapy for Head and Neck Squamous Cell Carcinoma
- (2011) Travis D. Reeves et al. OTOLARYNGOLOGY-HEAD AND NECK SURGERY
- HGF and c-Met Participate in Paracrine Tumorigenic Pathways in Head and Neck Squamous Cell Cancer
- (2009) L. M. Knowles et al. CLINICAL CANCER RESEARCH
- Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
- (2009) W. Wang et al. CLINICAL CANCER RESEARCH
- Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
- (2009) James A Bonner et al. LANCET ONCOLOGY
- Nuclear EGFR contributes to acquired resistance to cetuximab
- (2009) C Li et al. ONCOGENE
- Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression
- (2008) R. F. Hwang et al. CANCER RESEARCH
- Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer
- (2008) Jan B. Vermorken et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
- (2008) D L Wheeler et al. ONCOGENE
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