New predictors for immunotherapy responses sharpen our view of the tumour microenvironment

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens

(2018) Jeff DeFalco et al.   CLINICAL IMMUNOLOGY

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Antigen-Presenting Intratumoral B Cells Affect CD4 + TIL Phenotypes in Non–Small Cell Lung Cancer Patients

(2017) Tullia C. Bruno et al.   Cancer Immunology Research

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

Characterization of tumor-associated B-cell subsets in patients with colorectal cancer

(2015) Alexander Shimabukuro-Vornhagen et al.   Oncotarget

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

Human CD19+CD25high B regulatory cells suppress proliferation of CD4+ T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells

(2011) Aharon Kessel et al.   AUTOIMMUNITY REVIEWS

Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates

(2010) Julie R. Brahmer et al.   JOURNAL OF CLINICAL ONCOLOGY

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

(2010) Massimo Ammirante et al.   NATURE