Properties, Pharmacology, and Pharmacokinetics of Active Indole and Oxindole Alkaloids in Uncaria Hook

Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis

(2020) Takashi Matsumoto et al.   Scientific Reports

Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC–MS/MS and Its Application in Pharmacokinetics and Bioavailability

(2020) Lianguo Chen et al.   Biomed Research International

Gender differences in plasma pharmacokinetics and hepatic metabolism of geissoschizine methyl ether from Uncaria hook in rats

(2020) Hirotaka Kushida et al.   JOURNAL OF ETHNOPHARMACOLOGY

Identification of the absorbed components and their metabolites of Tianma-Gouteng granule in rat plasma and bile using ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry

(2019) Hongye Zhang et al.   BIOMEDICAL CHROMATOGRAPHY

LC-MS/MS detection of citrus unshiu peel-derived flavonoids in the plasma and brain after oral administration of yokukansankachimpihange in rats

(2019) Mikina Takiyama et al.   XENOBIOTICA

Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

(2019) Chunyuan Zhang et al.   Evidence-based Complementary and Alternative Medicine

Uncaria rhynchophylla and Its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions

(2019) Wen Yang et al.   Current Vascular Pharmacology

Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

(2018) Yasushi Ikarashi et al.   CURRENT MEDICINAL CHEMISTRY

Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng - Baitouweng (GB) in rats

(2018) Xiaoting Tian et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Chotosan ameliorates cognitive impairment and hippocampus neuronal loss in experimental vascular dementia via activating the Nrf2-mediated antioxidant pathway

(2018) Pan Jiang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Basic Study of Drug-Drug Interaction between Memantine and the Traditional Japanese Kampo Medicine Yokukansan

(2018) Takashi Matsumoto et al.   MOLECULES

Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats

(2017) Xin Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The profiling of the metabolites of hirsutine in rat by ultra-high performance liquid chromatography coupled with linear ion trap Orbitrap mass spectrometry: An improved strategy for the systematic screening and identification of metabolites in multi-samples in vivo

(2017) Jianwei Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The Blood-Brain Barrier Permeability of Six Indole Alkaloids from Uncariae Ramulus Cum Uncis in the MDCK-pHaMDR Cell Monolayer Model

(2017) Yi-Nan Zhang et al.   MOLECULES

Isorhynchophylline Attenuates MPP+-Induced Apoptosis Through Endoplasmic Reticulum Stress- and Mitochondria-Dependent Pathways in PC12 Cells: Involvement of Antioxidant Activity

(2017) Xiao-Ming Li et al.   NEUROMOLECULAR MEDICINE

Characteristic Chromatogram: A Method of Discriminate and Quantitative Analysis for Quality Evaluation of Uncaria Stem with Hooks

(2017) Jinjun Hou et al.   PLANTA MEDICA

Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells

(2017) Kazushige Mizoguchi et al.   Frontiers in Pharmacology

Yokukansan and Yokukansankachimpihange Ameliorate Aggressive Behaviors in Rats with Cholinergic Degeneration in the Nucleus Basalis of Meynert

(2017) Masahiro Tabuchi et al.   Frontiers in Pharmacology

Distribution Analysis via Mass Spectrometry Imaging of Ephedrine in the Lungs of Rats Orally Administered the Japanese Kampo Medicine Maoto

(2017) Takashi Matsumoto et al.   Scientific Reports

Effective Separation and Simultaneous Determination of Corynoxeine and Its Metabolites in Rats by High-Performance Liquid Chromatography with Tandem Mass Spectrometry and Application to Pharmacokinetics and In Vivo Distribution in Main Organs

(2016) Wei WANG et al.   ANALYTICAL SCIENCES

Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT

(2016) Yasushi Ishida et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pharmacokinetic study of isocorynoxeine metabolites mediated by cytochrome P450 enzymes in rat and human liver microsomes

(2016) Lizhu Zhao et al.   FITOTERAPIA

Profiling and identification of metabolites of isorhynchophylline in rats by ultra high performance liquid chromatography and linear ion trap Orbitrap mass spectrometry

(2016) Jianwei Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the ‘Neuronal Warburg Effect’

(2016) Jiahong Sun et al.   JOURNAL OF ETHNOPHARMACOLOGY

Direct Visualization of Neurotransmitters in Rat Brain Slices by Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI - MS)

(2016) Anna Maria A. P. Fernandes et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Antidepressant-Like Effect of Isorhynchophylline in Mice

(2016) Yan-Fang Xian et al.   NEUROCHEMICAL RESEARCH

Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients

(2016) Yasushi Ikarashi et al.   PHARMACOLOGY & THERAPEUTICS

Metabolism of isorhynchophylline in rats detected by LC-MS

(2016) Wei Wang et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging

(2016) Silvia Giordano et al.   Scientific Reports

Interaction of Drug or Food with Drug Transporters in Intestine and Liver

(2015) Takeo Nakanishi et al.   CURRENT DRUG METABOLISM

Metabolic Profile of Isocorynoxeine in Rats Obtained by Ultra-High Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

(2015) Lizhu Zhao et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria

(2015) Qian Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

(2015) Hirotaka Kushida et al.   MOLECULES

In vitroidentification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan

(2015) Takashi Matsumoto et al.   XENOBIOTICA

Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease

(2015) Liang-Feng Liu et al.   Scientific Reports

Yokukansan, a Kampo Medicine, Protects PC12 Cells from Glutamate-Induced Death by Augmenting Gene Expression of Cystine/Glutamate Antiporter System Xc−

(2015) Hitomi Kanno et al.   PLoS One

Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

Structural elucidation of rat biliary metabolites of corynoxeine and their quantification using LC-MSn

(2014) Wei Wang et al.   BIOMEDICAL CHROMATOGRAPHY

Qualitative and Quantitative Analyses of Alkaloids in Uncaria Species by UPLC-ESI-Q-TOF/MS

(2014) Hai-Bo Wang et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Alkaloids from the hook-bearing branch ofUncariarhynchophyllaand their neuroprotective effects against glutamate-induced HT22 cell death

(2014) Wen Qi et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

The metabolism of YiGan San and subsequent pharmacokinetic evaluation of four metabolites in rat based on liquid chromatography with tandem mass spectrometry

(2014) Yanan Gai et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Specific binding and characteristics of geissoschizine methyl ether, an indole alkaloid of Uncaria Hook, in the rat brain

(2014) Kazushige Mizoguchi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Isolation and Identification of Twelve Metabolites of Isocorynoxeine in Rat Urine and their Neuroprotective Activities in HT22 Cell Assay

(2014) Wen Qi et al.   PLANTA MEDICA

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometr

(2013) Hirotaka Kushida et al.   BIOMEDICAL CHROMATOGRAPHY

A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies

(2013) Andre Ndagijimana et al.   FITOTERAPIA

Kampo Formulations, Chotosan, and Yokukansan, for Dementia Therapy: Existing Clinical and Preclinical Evidence

(2013) Kinzo Matsumoto et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Physiology of Blood–Brain Interfaces in Relation to Brain Disposition of Small Compounds and Macromolecules

(2013) N. Strazielle et al.   MOLECULAR PHARMACEUTICS

Antianxiety-Like Effects of Chimpi (Dried Citrus Peels) in the Elevated Open-Platform Test

(2013) Aya Ito et al.   MOLECULES

Yokukansan, a traditional Japanese herbal medicine, alleviates the emotional abnormality induced by maladaptation to stress in mice

(2013) Minoru Tsuji et al.   PHYTOMEDICINE

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

Effects of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook, a Constituent of Yokukansan, on Human Recombinant Serotonin7 Receptor

(2012) Toshiyuki Ueki et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Bioassay-Guided Isolation of Neuroprotective Compounds fromUncaria rhynchophyllaagainst Beta-Amyloid-Induced Neurotoxicity

(2012) Yan-Fang Xian et al.   Evidence-based Complementary and Alternative Medicine

Yokukansan inhibits morphine tolerance and physical dependence in mice: The role of α2A-adrenoceptor

(2012) T. Nakagawa et al.   NEUROSCIENCE

Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin1A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan

(2012) A. Nishi et al.   NEUROSCIENCE

Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan

(2011) Zenji Kawakami et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

(2011) Sachiko Imamura et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Geissoschizine methyl ether has third-generation antipsychotic-like actions at the dopamine and serotonin receptors

(2011) Takashi Ueda et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabolism and Pharmacokinetics of Rhynchophylline in Rats

(2010) Wei Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Corynoxeine Isolated from the Hook of Uncaria rhynchophylla Inhibits Rat Aortic Vascular Smooth Muscle Cell Proliferation through the Blocking of Extracellular Signal Regulated Kinase 1/2 Phosphorylation

(2008) Tack-Joong Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL