Gender differences in plasma pharmacokinetics and hepatic metabolism of geissoschizine methyl ether from Uncaria hook in rats

Identification of the absorbed components and their metabolites of Tianma-Gouteng granule in rat plasma and bile using ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry

(2019) Hongye Zhang et al.   BIOMEDICAL CHROMATOGRAPHY

Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

(2018) Yasushi Ikarashi et al.   CURRENT MEDICINAL CHEMISTRY

Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng - Baitouweng (GB) in rats

(2018) Xiaoting Tian et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells

(2017) Kazushige Mizoguchi et al.   Frontiers in Pharmacology

Yokukansan and Yokukansankachimpihange Ameliorate Aggressive Behaviors in Rats with Cholinergic Degeneration in the Nucleus Basalis of Meynert

(2017) Masahiro Tabuchi et al.   Frontiers in Pharmacology

Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients

(2016) Yasushi Ikarashi et al.   PHARMACOLOGY & THERAPEUTICS

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

(2015) Hirotaka Kushida et al.   MOLECULES

In vitroidentification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan

(2015) Takashi Matsumoto et al.   XENOBIOTICA

Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometr

(2013) Hirotaka Kushida et al.   BIOMEDICAL CHROMATOGRAPHY

Antianxiety-Like Effects of Chimpi (Dried Citrus Peels) in the Elevated Open-Platform Test

(2013) Aya Ito et al.   MOLECULES

Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs

(2013) Haruka Nishimuta et al.   XENOBIOTICA

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

(2011) Sachiko Imamura et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

(2009) Deepak Dalvie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains

(2009) A. Bruyère et al.   XENOBIOTICA

Effects of Kampo Medicines on CYP and P-gp Activity in Vitro

(2008) Kiyomi Ito et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats

(2008) D. Mitschke et al.   DRUG METABOLISM AND DISPOSITION