Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation

(2018) Yan-Fang Xian et al.   JOURNAL OF ALZHEIMERS DISEASE

Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats

(2017) Xin Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Profiling and identification of metabolites of isorhynchophylline in rats by ultra high performance liquid chromatography and linear ion trap Orbitrap mass spectrometry

(2016) Jianwei Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Stereoselective pharmacokinetic study of rhynchophylline and isorhynchophylline epimers in rat plasma by liquid chromatography–tandem mass spectrometry

(2016) Xin Wang et al.   XENOBIOTICA

Metabolism of isorhynchophylline in rats detected by LC-MS

(2016) Wei Wang et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Structural Stabilities and Transformation Mechanism of Rhynchophylline and Isorhynchophylline by Ultra Performance Liquid Chromatography/Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS)

(2015) Zhen-Feng Wu et al.   MOLECULES

Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats

(2015) Hui Shao et al.   NEUROCHEMICAL RESEARCH

Plant alkaloids as drug leads for Alzheimer's disease

(2015) Yu Pong Ng et al.   NEUROCHEMISTRY INTERNATIONAL

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Urinary metabolites of isorhynchophylline in rats and their neuroprotective activities in the HT22 cell assay

(2014) Fangfang Chen et al.   FITOTERAPIA

Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice

(2014) Yan-Fang Xian et al.   NEUROCHEMISTRY INTERNATIONAL

Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

(2014) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway

(2013) Yan-Fang Xian et al.   Evidence-based Complementary and Alternative Medicine

Determination of Rhynchophylline in Rat Plasma by Liquid Chromatography Mass Spectrometry and Its Application

(2013) J. Cai et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease

(2013) Eduardo Luis Konrath et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bioassay-Guided Isolation of Neuroprotective Compounds fromUncaria rhynchophyllaagainst Beta-Amyloid-Induced Neurotoxicity

(2012) Yan-Fang Xian et al.   Evidence-based Complementary and Alternative Medicine

Protective Effect of Isorhynchophylline Against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2011) Yan-Fang Xian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

(2011) Sachiko Imamura et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Uncaria rhynchophyllaAmeliorates Cognitive Deficits Induced by D-galactose in Mice

(2011) Yan-Fang Xian et al.   PLANTA MEDICA

Metabolism and Pharmacokinetics of Rhynchophylline in Rats

(2010) Wei Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism

(2009) Dan Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY