Yokukansan and Yokukansankachimpihange Ameliorate Aggressive Behaviors in Rats with Cholinergic Degeneration in the Nucleus Basalis of Meynert

Yokukansan Increases 5-HT1AReceptors in the Prefrontal Cortex and Enhances 5-HT1AReceptor Agonist-Induced Behavioral Responses in Socially Isolated Mice

(2015) Toshiyuki Ueki et al.   Evidence-based Complementary and Alternative Medicine

Specific binding and characteristics of geissoschizine methyl ether, an indole alkaloid of Uncaria Hook, in the rat brain

(2014) Kazushige Mizoguchi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometr

(2013) Hirotaka Kushida et al.   BIOMEDICAL CHROMATOGRAPHY

Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease

(2013) M.-Marsel Mesulam   JOURNAL OF COMPARATIVE NEUROLOGY

Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice

(2012) Atsushi Takeda et al.   BRAIN RESEARCH BULLETIN

Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin1A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan

(2012) A. Nishi et al.   NEUROSCIENCE

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

(2011) Sachiko Imamura et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice

(2011) H. Fujiwara et al.   NEUROSCIENCE

The cholinergic system and Parkinson disease

(2010) Nicolaas I. Bohnen et al.   BEHAVIOURAL BRAIN RESEARCH

Electron-microscopic examination of effects of yokukansan, a traditional Japanese medicine, on degeneration of cerebral cells in thiamine-deficient rats

(2010) Seiichi Iizuka et al.   NEUROPATHOLOGY

Effects of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventricular injection of amyloid β protein in mice

(2010) Kyoji Sekiguchi et al.   PHYTOTHERAPY RESEARCH

Effects of Yokukansan, a Traditional Japanese Medicine, on Memory Disturbance and Behavioral and Psychological Symptoms of Dementia in Thiamine-Deficient Rats

(2009) Yasushi Ikarashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Glycyrrhizin and its metabolite 18β-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes

(2009) Zenji Kawakami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine

(2009) Joanne Rodda et al.   INTERNATIONAL PSYCHOGERIATRICS

Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells

(2009) Kiyoshi Terawaki et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats

(2009) Hitomi Kanno et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells

(2009) Z. Kawakami et al.   NEUROSCIENCE

A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia

(2008) Katsuyoshi Mizukami et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats

(2008) Atsushi Takeda et al.   NUTRITIONAL NEUROSCIENCE

Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis

(2007) S. Gauthier et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY