LC-MS/MS detection of citrus unshiu peel-derived flavonoids in the plasma and brain after oral administration of yokukansankachimpihange in rats

Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

(2018) Yasushi Ikarashi et al.   CURRENT MEDICINAL CHEMISTRY

Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells

(2017) Kazushige Mizoguchi et al.   Frontiers in Pharmacology

Yokukansan and Yokukansankachimpihange Ameliorate Aggressive Behaviors in Rats with Cholinergic Degeneration in the Nucleus Basalis of Meynert

(2017) Masahiro Tabuchi et al.   Frontiers in Pharmacology

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

(2017) Ayako Shinozaki et al.   PLoS One

An Extract of Chinpi, the Dried Peel of the Citrus Fruit Unshiu, Enhances Axonal Remyelination via Promoting the Proliferation of Oligodendrocyte Progenitor Cells

(2016) Hideaki Tokunaga et al.   Evidence-based Complementary and Alternative Medicine

Herbal medicine for management of the behavioural and psychological symptoms of dementia (BPSD): A systematic review and meta-analysis

(2016) Anna J Hyde et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients

(2016) Yasushi Ikarashi et al.   PHARMACOLOGY & THERAPEUTICS

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

(2015) Hirotaka Kushida et al.   MOLECULES

Naringenin Mitigates Iron-Induced Anxiety-Like Behavioral Impairment, Mitochondrial Dysfunctions, Ectonucleotidases and Acetylcholinesterase Alteration Activities in Rat Hippocampus

(2015) Yassine Chtourou et al.   NEUROCHEMICAL RESEARCH

Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin — A mini-review

(2014) Ali Roohbakhsh et al.   LIFE SCIENCES

Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents

(2013) Ju Hyeong Lyu et al.   ARCHIVES OF PHARMACAL RESEARCH

Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometr

(2013) Hirotaka Kushida et al.   BIOMEDICAL CHROMATOGRAPHY

Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials

(2013) Yuki Matsuda et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Antianxiety-Like Effects of Chimpi (Dried Citrus Peels) in the Elevated Open-Platform Test

(2013) Aya Ito et al.   MOLECULES

Transport of active flavonoids, based on cytotoxicity and lipophilicity: An evaluation using the blood–brain barrier cell and Caco-2 cell models

(2013) Yuya Yang et al.   TOXICOLOGY IN VITRO

The Blood–Brain Barrier Permeability of 18β-Glycyrrhetinic Acid, a Major Metabolite of Glycyrrhizin in Glycyrrhiza Root, a Constituent of the Traditional Japanese Medicine Yokukansan

(2012) Masahiro Tabuchi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Isolation and Characterization of Activators of ERK/MAPK from Citrus Plants

(2012) Yoshiko Furukawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effects of Citrus Flavonoids

(2012) Sam-Long Hwang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice

(2012) Satoshi Okuyama et al.   NEUROSCIENCE LETTERS

Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: An open-label trial

(2012) Ken Nagata et al.   PHYTOMEDICINE

The Influence of Glycyrrhiza and Antibiotics on the Purgative Action of Sennoside A from Daiokanzoto in Mice

(2011) Emi Matsui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

(2011) Sachiko Imamura et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination

(2010) Nanako Sato et al.   Evidence-based Complementary and Alternative Medicine

Preventive Action of Nobiletin, a Constituent of AURANTII NOBILIS PERICARPIUM with Anti-dementia Activity, against Amyloid-β Peptide-induced Neurotoxicity Expression and Memory Impairment

(2010) Tohru YAMAKUNI et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Effects of Yokukansan, a Traditional Japanese Medicine, on Memory Disturbance and Behavioral and Psychological Symptoms of Dementia in Thiamine-Deficient Rats

(2009) Yasushi Ikarashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation

(2009) Yui Yamamoto et al.   BRAIN RESEARCH

Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease

(2008) Masahiro Tabuchi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A  Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2008) H. Onozuka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS