Basic Study of Drug-Drug Interaction between Memantine and the Traditional Japanese Kampo Medicine Yokukansan

Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

(2018) Yasushi Ikarashi et al.   CURRENT MEDICINAL CHEMISTRY

Yokukansan, a Traditional Japanese Medicine, Enhances the Glutamate Transporter GLT-1 Function in Cultured Rat Cortical Astrocytes

(2018) Toshiyuki Ueki et al.   Evidence-based Complementary and Alternative Medicine

Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine

(2017) Fabian Müller et al.   MOLECULAR PHARMACEUTICS

Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells

(2017) Kazushige Mizoguchi et al.   Frontiers in Pharmacology

Multiple Psychopharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan, and the Brain Regions it Affects

(2017) Kazushige Mizoguchi et al.   Frontiers in Pharmacology

The Effect of Yokukansan, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug–Metabolizing Enzyme Activities in Healthy Male Volunteers

(2016) Hiromi Soraoka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients

(2016) Yasushi Ikarashi et al.   PHARMACOLOGY & THERAPEUTICS

CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia

(2016) Sachiko Mogami et al.   Scientific Reports

Metabolic Profiling of the Uncaria Hook Alkaloid Geissoschizine Methyl Ether in Rat and Human Liver Microsomes Using High-Performance Liquid Chromatography with Tandem Mass Spectrometry

(2015) Hirotaka Kushida et al.   MOLECULES

Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

In vitroidentification of human cytochrome P450 isoforms involved in the metabolism of Geissoschizine methyl ether, an active component of the traditional Japanese medicine Yokukansan

(2015) Takashi Matsumoto et al.   XENOBIOTICA

Potential drug–drug interactions in Alzheimer patients with behavioral symptoms

(2015) Fabio Monzani et al.   Clinical Interventions in Aging

Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study

(2015) Hiroyuki Kitagawa et al.   PLoS One

3-Monoglucuronyl Glycyrrhretinic Acid Is a Possible Marker Compound Related to Licorice-Induced Pseudoaldosteronism

(2014) Toshiaki Makino   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The metabolism of YiGan San and subsequent pharmacokinetic evaluation of four metabolites in rat based on liquid chromatography with tandem mass spectrometry

(2014) Yanan Gai et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Simultaneous quantitative analyses of indole and oxindole alkaloids of Uncaria Hook in rat plasma and brain after oral administration of the traditional Japanese medicine Yokukansan using high-performance liquid chromatography with tandem mass spectrometr

(2013) Hirotaka Kushida et al.   BIOMEDICAL CHROMATOGRAPHY

Population Pharmacokinetic Study of Memantine: Effects of Clinical and Genetic Factors

(2013) Muriel Noetzli et al.   CLINICAL PHARMACOKINETICS

Yokukansan in the treatment of behavioral and psychological symptoms of dementia: a systematic review and meta-analysis of randomized controlled trials

(2013) Yuki Matsuda et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

The Blood–Brain Barrier Permeability of 18β-Glycyrrhetinic Acid, a Major Metabolite of Glycyrrhizin in Glycyrrhiza Root, a Constituent of the Traditional Japanese Medicine Yokukansan

(2012) Masahiro Tabuchi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Role of Memantine in the Treatment of Psychiatric Disorders Other Than the Dementias

(2012) Gabriele Sani et al.   CNS DRUGS

Geissoschizine methyl ether, an alkaloid in Uncaria hook, is a potent serotonin1A receptor agonist and candidate for amelioration of aggressiveness and sociality by yokukansan

(2012) A. Nishi et al.   NEUROSCIENCE

Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine

(2012) Koh IWASAKI et al.   Psychogeriatrics

Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan

(2011) Zenji Kawakami et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

(2011) Sachiko Imamura et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid β proteins in amyloid precursor protein transgenic mice

(2011) H. Fujiwara et al.   NEUROSCIENCE

Ameliorative effect of traditional Japanese medicine yokukansan on age-related impairments of working memory and reversal learning in rats

(2010) K. Mizoguchi et al.   NEUROSCIENCE

Effects of Yokukansan, a Traditional Japanese Medicine, on Memory Disturbance and Behavioral and Psychological Symptoms of Dementia in Thiamine-Deficient Rats

(2009) Yasushi Ikarashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Glycyrrhizin and its metabolite 18β-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes

(2009) Zenji Kawakami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective effects of yokukansan, a traditional japanese medicine, on glutamate-mediated excitotoxicity in cultured cells

(2009) Z. Kawakami et al.   NEUROSCIENCE

Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloidβprotein into mice

(2009) Kyoji Sekiguchi et al.   PHYTOTHERAPY RESEARCH

Effects of Kampo Medicines on CYP and P-gp Activity in Vitro

(2008) Kiyomi Ito et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Glucuronide-sulfate Diconjugate as a Novel Metabolite of Glycyrrhetic Acid in Rat Bile

(2008) Jing Jing et al.   Drug Metabolism and Pharmacokinetics

A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia

(2008) Katsuyoshi Mizukami et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer's disease

(2008) Masahiro Tabuchi et al.   JOURNAL OF ETHNOPHARMACOLOGY