Astrocyte function from information processing to cognition and cognitive impairment

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

(2018) Nicole Reichenbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gliotransmission: Beyond Black-and-White

(2018) Iaroslav Savtchouk et al.   JOURNAL OF NEUROSCIENCE

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Istradefylline reduces memory deficits in aging mice with amyloid pathology

(2018) Anna G. Orr et al.   NEUROBIOLOGY OF DISEASE

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

(2018) Jillian L. Stobart et al.   NEURON

Astroglial CB 1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

(2018) Laurie M. Robin et al.   NEURON

Hippocampal ripples down-regulate synapses

(2018) Hiroaki Norimoto et al.   SCIENCE

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes

(2018) Letizia Mariotti et al.   Nature Communications

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

(2018) Ana Covelo et al.   eLife

Neuron-astrocyte signaling is preserved in the aging brain

(2017) Marta Gómez-Gonzalo et al.   GLIA

Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function

(2017) Vanessa Morais Sardinha et al.   GLIA

Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

(2017) Kouki Makitani et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Synapse-specific astrocyte gating of amygdala-related behavior

(2017) Mario Martin-Fernandez et al.   NATURE NEUROSCIENCE

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

(2017) Thomas Papouin et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

(2017) Jerome Clasadonte et al.   NEURON

Synaptic functions of endocannabinoid signaling in health and disease

(2017) Alfonso Araque et al.   NEUROPHARMACOLOGY

Astrocytes locally translate transcripts in their peripheral processes

(2017) Kristina Sakers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

(2017) Zhibing Tan et al.   Nature Communications

Morphine-induced inhibition of Ca2+ -dependent d -serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens

(2016) Jian Wu et al.   ADDICTION BIOLOGY

Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse

(2016) Yan Zhang et al.   BIOLOGICAL PSYCHIATRY

Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus

(2016) Yuniesky Andrade-Talavera et al.   CEREBRAL CORTEX

Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model

(2016) Chelsea Cavanagh et al.   NEUROBIOLOGY OF AGING

Astrocyte Intermediaries of Septal Cholinergic Modulation in the Hippocampus

(2016) Milan Pabst et al.   NEURON

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

d-Serine in the nucleus accumbens region modulates behavioral sensitization and extinction of conditioned place preference

(2016) Zhi-Qiang Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Impairments of neural circuit function in Alzheimer's disease

(2016) Marc Aurel Busche et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

(2016) Virginia Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active dendrites regulate the impact of gliotransmission on rat hippocampal pyramidal neurons

(2016) Sufyan Ashhad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes regulate cortical state switching in vivo

(2016) Kira E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astroglial networks promote neuronal coordination

(2016) Oana Chever et al.   Science Signaling

Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus

(2016) Elias Gebara et al.   STEM CELLS

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

(2016) Gertrudis Perea et al.   eLife

Astroglial networks promote neuronal coordination

(2016) Oana Chever et al.   Science Signaling

Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice

(2016) Cathy Joanna Jensen et al.   PLoS One

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

(2015) Marco Matos et al.   BIOLOGICAL PSYCHIATRY

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

(2015) Michael D. Scofield et al.   BIOLOGICAL PSYCHIATRY

Perisynaptic astroglial processes: dynamic processors of neuronal information

(2015) Grégory Ghézali et al.   Brain Structure & Function

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

Disrupting astrocyte–neuron lactate transfer persistently reduces conditioned responses to cocaine

(2015) B Boury-Jamot et al.   MOLECULAR PSYCHIATRY

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

(2015) Katie C Bittner et al.   NATURE NEUROSCIENCE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes

(2015) Sébastien Sultan et al.   NEURON

D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats

(2015) Taban Seif et al.   NEUROPSYCHOPHARMACOLOGY

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

(2015) R. Martin et al.   SCIENCE

Genetic control of astrocyte function in neural circuits

(2015) Hannah M. Jahn et al.   Frontiers in Cellular Neuroscience

Role for astroglial α1-adrenoreceptors in gliotransmission and control of synaptic plasticity in the neocortex

(2015) Yuriy Pankratov et al.   Frontiers in Cellular Neuroscience

Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

(2015) Nicolas Toni et al.   Cold Spring Harbor Perspectives in Biology

Astrocytes Control Synapse Formation, Function, and Elimination

(2015) Won-Suk Chung et al.   Cold Spring Harbor Perspectives in Biology

The Molecular and Systems Biology of Memory

(2014) Eric R. Kandel et al.   CELL

Endocannabinoids Induce Lateral Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission

(2014) Marta Gómez-Gonzalo et al.   CEREBRAL CORTEX

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability

(2014) Yann Bernardinelli et al.   CURRENT BIOLOGY

Structural and Functional Plasticity of Astrocyte Processes and Dendritic Spine Interactions

(2014) A. Perez-Alvarez et al.   JOURNAL OF NEUROSCIENCE

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

(2014) T. Fujita et al.   JOURNAL OF NEUROSCIENCE

An Adaptive Role of TNF  in the Regulation of Striatal Synapses

(2014) G. M. Lewitus et al.   JOURNAL OF NEUROSCIENCE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

(2014) Ulrike Pannasch et al.   NATURE NEUROSCIENCE

Astrocyte Ca2+ signalling: an unexpected complexity

(2014) Andrea Volterra et al.   NATURE REVIEWS NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Astrocytes contribute to gamma oscillations and recognition memory

(2014) H. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer’s disease model

(2014) Zheng Wu et al.   Nature Communications

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Astrocyte IP3R2-dependent Ca2+ signaling is not a major modulator of neuronal pathways governing behavior

(2014) Jeremy Petravicz et al.   Frontiers in Behavioral Neuroscience

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

Reduced d-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity

(2013) Livia Curcio et al.   BRAIN

Impaired Development and Competitive Refinement of the Cortical Frequency Map in Tumor Necrosis Factor- -Deficient Mice

(2013) S. Yang et al.   CEREBRAL CORTEX

Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks

(2013) Ted Abel et al.   CURRENT BIOLOGY

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB

(2013) Dmitry Lim et al.   GLIA

Synapses lacking astrocyte appear in the amygdala during consolidation of pavlovian threat conditioning

(2013) Linnaea E. Ostroff et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice

(2013) Stanislaw Mitew et al.   NEUROBIOLOGY OF AGING

Glial Biology in Learning and Cognition

(2013) R. Douglas Fields et al.   NEUROSCIENTIST

Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior

(2013) David-Marian Otte et al.   PLoS One

α7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: Aβ Effects in a Preclinical Alzheimer’s Mouse Model

(2013) Tiina Maria Pirttimaki et al.   PLoS One

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decay happens: the role of active forgetting in memory

(2013) Oliver Hardt et al.   TRENDS IN COGNITIVE SCIENCES

Emerging role for astroglial networks in information processing: from synapse to behavior

(2013) Ulrike Pannasch et al.   TRENDS IN NEUROSCIENCES

Light sleep versus slow wave sleep in memory consolidation: a question of global versus local processes?

(2013) Lisa Genzel et al.   TRENDS IN NEUROSCIENCES

A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework

(2013) Shivendra Tewari et al.   Frontiers in Computational Neuroscience

Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses

(2013) Mika Tanaka et al.   Molecular Brain

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD

(2012) Jing Han et al.   CELL

Cell Selective Conditional Null Mutations of Serine Racemase Demonstrate a Predominate Localization in Cortical Glutamatergic Neurons

(2012) Michael A. Benneyworth et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments

(2012) Mahmood Amiri et al.   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

(2012) M. E. Hamby et al.   JOURNAL OF NEUROSCIENCE

Wakefulness Affects Synaptic and Network Activity by Increasing Extracellular Astrocyte-Derived Adenosine

(2012) L. I. Schmitt et al.   JOURNAL OF NEUROSCIENCE

Astrocyte signaling controls spike timing–dependent depression at neocortical synapses

(2012) Rogier Min et al.   NATURE NEUROSCIENCE

Relevance of Exocytotic Glutamate Release from Retinal Glia

(2012) Michal Slezak et al.   NEURON

D-serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference

(2012) Sherri Hammond et al.   NEUROPHARMACOLOGY

Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes

(2012) N. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination

(2012) A. S. Saab et al.   SCIENCE

TNFα in synaptic function: switching gears

(2012) Mirko Santello et al.   TRENDS IN NEUROSCIENCES

Astrocytes Mediate In Vivo Cholinergic-Induced Synaptic Plasticity

(2012) Marta Navarrete et al.   PLOS BIOLOGY

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

(2011) Aude Panatier et al.   CELL

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

(2011) C. Florian et al.   JOURNAL OF NEUROSCIENCE

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

(2011) N. Takata et al.   JOURNAL OF NEUROSCIENCE

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

TNFα Controls Glutamatergic Gliotransmission in the Hippocampal Dentate Gyrus

(2011) Mirko Santello et al.   NEURON

Artificial Astrocytes Improve Neural Network Performance

(2011) Ana B. Porto-Pazos et al.   PLoS One

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Astrocytic regulation of cortical UP states

(2011) K. E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Action-Potential Modulation During Axonal Conduction

(2011) T. Sasaki et al.   SCIENCE

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

(2010) Marta Navarrete et al.   NEURON

D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration

(2010) L. Kelamangalath et al.   NEUROSCIENCE

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

(2010) Xiao-Jing Wang   PHYSIOLOGICAL REVIEWS

Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca2+ Signaling

(2010) C. Agulhon et al.   SCIENCE

Synaptic potentiation induces increased glial coverage of excitatory synapses in CA1 hippocampus

(2009) Irina Lushnikova et al.   HIPPOCAMPUS

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

(2009) Alessandro Filosa et al.   NATURE NEUROSCIENCE

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo

(2009) T. Fellin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Endocannabinoids Mediate Neuron-Astrocyte Communication

(2008) Marta Navarrete et al.   NEURON