Novel Therapies for Parkinsonian Syndromes–Recent Progress and Future Perspectives

Isoform-selective decrease of glycogen synthase kinase-3 beta (GSK-3β) reduces synaptic tau phosphorylation, trans-cellular spreading and aggregation

(2021) Ana Claudia Amaral et al.   iScience

Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro

(2020) J. A. Clark et al.   Scientific Reports

Is brain perfusion a differentiating feature in the comparison of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)?

(2020) Piotr Alster et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Nilotinib Fails to Prevent Synucleinopathy and Cell Loss in a Mouse Model of Multiple System Atrophy

(2020) Miguel Lopez-Cuina et al.   MOVEMENT DISORDERS

MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

(2020) Xiaohai Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural Refinement of the Tubulin Ligand (+)-Discodermolide to Attenuate Chemotherapy-Mediated Senescence

(2020) Boying Guo et al.   MOLECULAR PHARMACOLOGY

A Phase 2 Study of AMO-02 (tideglusib) in Congenital and Childhood Onset Myotonic Dystrophy Type 1 (DM1)

(2020) Joseph Horrigan et al.   PEDIATRIC NEUROLOGY

Mesenchymal stem cells modulate misfolded α-synuclein in parkinsonian disorders: A multitarget disease-modifying strategy

(2020) Jin Young Shin et al.   Stem Cell Research

Inosine 5'‐Monophosphate to Raise Serum Uric Acid Level in Multiple System Atrophy (IMPROVE‐MSA study)

(2020) Jae Jung Lee et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Phase 1 Randomized Trial of Specific Active α‐Synuclein Immunotherapies PD01A and PD03A in Multiple System Atrophy

(2020) Wassilios G. Meissner et al.   MOVEMENT DISORDERS

Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

(2020) M. Catarina Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease

(2020) Tanya Simuni et al.   JAMA Neurology

Associations Between Amantadine Usage, Gait, and Cognition in PSP: A post-hoc Analysis of the Davunetide Trial

(2020) Marian L. Dale et al.   Frontiers in Neurology

Effectiveness of Levodopa in Patients with Multiple System Atrophy and Associated Clinicopathological Features

(2020) Chiho Ishida et al.   INTERNAL MEDICINE

Corticobasal degeneration

(2019) Per Svenningsson   CURRENT OPINION IN NEUROLOGY

Safety and preliminary efficacy of intranasal insulin for cognitive impairment in Parkinson disease and multiple system atrophy: A double-blinded placebo-controlled pilot study

(2019) Peter Novak et al.   PLoS One

Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy

(2019) Wolfgang Singer et al.   NEUROLOGY

Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease

(2019) Christopher H. van Dyck et al.   JAMA Neurology

Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives

(2019) Giacomo Monzio Compagnoni et al.   Acta Neuropathologica Communications

Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial

(2019) Johannes Levin et al.   LANCET NEUROLOGY

Therapeutic Potential of Neurotrophins for Repair After Brain Injury: A Helping Hand From Biomaterials

(2019) Josh Houlton et al.   Frontiers in Neuroscience

CDK5-dependent BAG3 degradation modulates synaptic protein turnover

(2019) Jiechao Zhou et al.   BIOLOGICAL PSYCHIATRY

FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models

(2019) Guadalupe Vidal-Martinez et al.   EXPERIMENTAL NEUROLOGY

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome

(2019) Richard M. Tsai et al.   JAMA Neurology

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice

(2019) Hayk Davtyan et al.   Alzheimers Research & Therapy

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology

(2019) Anarmaa Mendsaikhan et al.   Acta Neuropathologica Communications

Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function

(2018) Yasuaki Aratani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Diagnosis of multiple system atrophy

(2018) Jose-Alberto Palma et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Tolfenamic Acid: A Modifier of the Tau Protein and its Role in Cognition and Tauopathy

(2018) Joanna K. Chang et al.   Current Alzheimer Research

Preclinical, phase I, and phase II investigational clinical trials for treatment of progressive supranuclear palsy

(2018) Ali Shoeibi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

(2018) Victor Tapias et al.   HUMAN MOLECULAR GENETICS

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1

(2018) Kurt A. Jellinger   JOURNAL OF ALZHEIMERS DISEASE

Microtubule defects in mesenchymal stromal cells distinguish patients with Progressive Supranuclear Palsy

(2018) Alessandra Maria Calogero et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

(2018) Owen Scudamore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study

(2018) Hee Kyung Park et al.   MOVEMENT DISORDERS

Difficulties in the diagnosis of four repeats (4R) tauopathic parkinsonian syndromes

(2018) Piotr Alster et al.   Neurologia i Neurochirurgia Polska

Anti-inflammatory drug use and progressive supranuclear palsy

(2018) Connie Marras et al.   PARKINSONISM & RELATED DISORDERS

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau

(2018) Cara L. Croft et al.   PLoS One

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

(2018) Martin Kallab et al.   Frontiers in Neuroscience

Long-term treatment with rotigotine in drug-naïve PSP patients

(2018) Tommaso Schirinzi et al.   ACTA NEUROLOGICA BELGICA

Tauopathy-Associated PERK Alleles are Functional Hypomorphs that Increase Neuronal Vulnerability to ER Stress

(2018) Shauna H Yuan et al.   HUMAN MOLECULAR GENETICS

Bioactive compounds against neglected diseases isolated from macroalgae: a review

(2018) Miriam Falkenberg et al.   JOURNAL OF APPLIED PHYCOLOGY

The chemistry of the vitamin B3 metabolome

(2018) Mikhail V. Makarov et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

(2018) Antonio Heras-Garvin et al.   MOVEMENT DISORDERS

Therapeutic approaches to target alpha-synuclein pathology

(2017) Patrik Brundin et al.   EXPERIMENTAL NEUROLOGY

Rolipram, a PDE-IV inhibitor protects against experimental Parkinsonism in mice

(2017) N. Kumar et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

(2017) Nicholas B. Hastings et al.   Molecular Neurodegeneration

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

(2017) Michael G. Agadjanyan et al.   Molecular Neurodegeneration

Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

(2017) Günter U. Höglinger et al.   MOVEMENT DISORDERS

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

MultiTEP platform-based DNA epitope vaccine targeting N-terminus of tau induces strong immune responses and reduces tau pathology in THY-Tau22 mice

(2017) Hayk Davtyan et al.   VACCINE

Biological functions of CDK5 and potential CDK5 targeted clinical treatments

(2017) Alison Shupp et al.   Oncotarget

Cell Biology and Pathophysiology of α-Synuclein

(2017) Jacqueline Burré et al.   Cold Spring Harbor Perspectives in Medicine

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy

(2017) Alana N. Vagnozzi et al.   Translational Psychiatry

Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?

(2017) Alexei A. Surguchev et al.   Frontiers in Molecular Neuroscience

Cytosolic Abnormally Hyperphosphorylated Tau But Not Paired Helical Filaments Sequester Normal MAPs and Inhibit Microtubule Assembly

(2017) Khalid Iqbal et al.   JOURNAL OF ALZHEIMERS DISEASE

PHARMACOKINETICS AND PHARMACODYNAMICS TO SUPPORT CLINICAL STUDIES OF MK-8719: AN O-GLCNACASE INHIBITOR FOR PROGRESSIVE SUPRANUCLEAR PALSY

(2016) Punam Sandhu et al.   Alzheimers & Dementia

Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice

(2016) Haitao Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Differential Diagnosis and Treatment of Atypical Parkinsonism

(2016) Johannes Levin et al.   Deutsches Arzteblatt International

Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration

(2016) E. G. Gentry et al.   JOURNAL OF NEUROSCIENCE

Finding a new therapeutic approach for no-option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy

(2016) Margherita Canesi et al.   Journal of Translational Medicine

Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes

(2016) Ian T.S. Coyle-Gilchrist et al.   NEUROLOGY

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

(2016) Kathleen M. Schoch et al.   NEURON

Serum uric acid levels in Parkinson's disease and related disorders

(2016) Hideki Sakuta et al.   Brain and Behavior

Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy

(2016) Vishruti Makani et al.   Acta Neuropathologica Communications

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo

(2016) Manon Domise et al.   Scientific Reports

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

(2015) Valeria Melis et al.   BEHAVIOURAL PHARMACOLOGY

Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy

(2015) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Neurodegeneration in the Brain of a Child Without Functional PKR-like Endoplasmic Reticulum Kinase

(2015) Julius Bruch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Efficacy of rasagiline in patients with the parkinsonian variant of multiple system atrophy: a randomised, placebo-controlled trial

(2015) Werner Poewe et al.   LANCET NEUROLOGY

Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy

(2015) Markus Mandler et al.   Molecular Neurodegeneration

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

(2015) Yingjun Zhao et al.   NEURON

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell–cell communication by chemokines

(2015) Stefka Gyoneva et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

(2015) Mehdi Djelloul et al.   Stem Cell Reports

Emergence of BCR-ABL Kinase Domain Mutations Associated with Newly Diagnosed Chronic Myeloid Leukemia: A Meta-Analysis of Clinical Trials of Tyrosine Kinase Inhibitors

(2015) Iulia D. Ursan et al.   Journal of Managed Care & Specialty Pharmacy

NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects

(2015) Christian Dölle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia

(2015) Iva Bozic et al.   PLoS One

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

(2014) Cliona Stack et al.   HUMAN MOLECULAR GENETICS

Autologous mesenchymal stem cell therapy for progressive supranuclear palsy: translation into a phase I controlled, randomized clinical study

(2014) Rosaria Giordano et al.   Journal of Translational Medicine

Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial

(2014) Adam L Boxer et al.   LANCET NEUROLOGY

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Methylene blue promotes quiescence of rat neural progenitor cells

(2014)   Frontiers in Cellular Neuroscience

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

Involvement of PI3K and ROCK signaling pathways in migration of bone marrow-derived mesenchymal stem cells through human brain microvascular endothelial cell monolayers

(2013) Mei-Na Lin et al.   BRAIN RESEARCH

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

Therapeutic Response to Pramipexole in a Patient with Multiple System Atrophy with Predominant Parkinsonism: Positron Emission Tomography and Pharmacokinetic Assessments

(2013) Masayuki Ueda et al.   INTERNAL MEDICINE

The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons

(2013) Anamitra Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Efficacy and Safety of A Liposome-Based Vaccine against Protein Tau, Assessed in Tau.P301L Mice That Model Tauopathy

(2013) Clara Theunis et al.   PLoS One

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson's Disease and Parkinsonism: Neuropathology

(2013) D. W. Dickson   Cold Spring Harbor Perspectives in Medicine

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo

(2012) Jose A. Morales-Garcia et al.   ACS Chemical Neuroscience

Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

(2012) Ana García-Osta et al.   ACS Chemical Neuroscience

Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy

(2012) Nadia Stefanova et al.   ACTA NEUROPATHOLOGICA

A randomized trial of mesenchymal stem cells in multiple system atrophy

(2012) Phil Hyu Lee et al.   ANNALS OF NEUROLOGY

Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

(2012) Kazuhiro Nakamura et al.   CELL

Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy

(2012) Kiren Ubhi et al.   EXPERIMENTAL NEUROLOGY

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration

(2012) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

(2012) Jin Chu et al.   Molecular Neurodegeneration

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

(2012) Scott A Yuzwa et al.   Nature Chemical Biology

Alteration of autophagosomal proteins in the brain of multiple system atrophy

(2012) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer’s Disease Mice

(2012) Saeromi Kim et al.   PLoS One

Increased Neuronal α-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling α-Synucleinopathies

(2012) Haya Kisos et al.   PLoS One

Amelioration of acute mercury toxicity by a novel, non-toxic lipid soluble chelator N,N′bis-(2-mercaptoethyl)isophthalamide: effect on animal survival, health, mercury excretion, and organ accumulation

(2012) David Clarke et al.   TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY

Clinicopathological correlations in corticobasal degeneration

(2011) Suzee E. Lee et al.   ANNALS OF NEUROLOGY

Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson’s disease

(2011) Lidia Cova et al.   APOPTOSIS

Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors

(2011) S. Schenone et al.   CURRENT MEDICINAL CHEMISTRY

Genetic Bases of Progressive Supranuclear Palsy: The MAPT Tau Disease

(2011) Barbara Borroni et al.   CURRENT MEDICINAL CHEMISTRY

Novel Lipid-Soluble Thiol-Redox Antioxidant and Heavy Metal Chelator, N,N′-bis(2-Mercaptoethyl)Isophthalamide (NBMI) and Phospholipase D-Specific Inhibitor, 5-Fluoro-2-Indolyl Des-Chlorohalopemide (FIPI) Attenuate Mercury-Induced Lipid Signaling Leading to Protection Against Cytotoxicity in Aortic Endothelial Cells

(2011) Jordan D. Secor et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Passive Immunization with Anti-Tau Antibodies in Two Transgenic Models

(2011) Xiyun Chai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Intranasal Insulin on Cognitive Function: A Systematic Review

(2011) Elad Shemesh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation

(2011) T. Nedachi et al.   NEUROSCIENCE

Mesenchymal Stem Cells in a Transgenic Mouse Model of Multiple System Atrophy: Immunomodulation and Neuroprotection

(2011) Sylvia Stemberger et al.   PLoS One

Papp–Lantos inclusions and the pathogenesis of multiple system atrophy: an update

(2010) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

Rational therapeutic approaches to progressive supranuclear palsy

(2010) M. Stamelou et al.   BRAIN

Powerful beneficial effects of benfotiamine on cognitive impairment and  -amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice

(2010) X. Pan et al.   BRAIN

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective Effect of Human Mesenchymal Stem Cells in an Animal Model of Double Toxin-Induced Multiple System Atrophy Parkinsonism

(2010) Hyun-Jung Park et al.   CELL TRANSPLANTATION

Neuropathology of variants of progressive supranuclear palsy

(2010) Dennis W Dickson et al.   CURRENT OPINION IN NEUROLOGY

CREB: a multifaceted regulator of neuronal plasticity and protection

(2010) Kensuke Sakamoto et al.   JOURNAL OF NEUROCHEMISTRY

Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors

(2010) K. Ubhi et al.   JOURNAL OF NEUROSCIENCE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Total synthesis of (−)-dictyostatin, a microtubule-stabilising anticancer macrolide of marine sponge origin

(2010) Ian Paterson et al.   TETRAHEDRON

Intracellular and extracellular tau

(2010) Jesús Avila   Frontiers in Neuroscience

Microtubule Depolymerization Suppresses α-Synuclein Accumulation in a Mouse Model of Multiple System Atrophy

(2009) Kimiko Nakayama et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural Basis for Stabilization of the Tau Pre-mRNA Splicing Regulatory Element by Novantrone (Mitoxantrone)

(2009) Suxin Zheng et al.   CHEMISTRY & BIOLOGY

Corticobasal degeneration

(2009) Stephen G. Reich et al.   Current Treatment Options in Neurology

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia

(2009) Duane L Guernsey et al.   NATURE GENETICS

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo

(2008) So Yong Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY

Tau exon 10 alternative splicing and tauopathies

(2008) Fei Liu et al.   Molecular Neurodegeneration

Short-term effects of coenzyme Q10 in progressive supranuclear palsy: A randomized, placebo-controlled trial

(2008) Maria Stamelou et al.   MOVEMENT DISORDERS

Second consensus statement on the diagnosis of multiple system atrophy

(2008) S. Gilman et al.   NEUROLOGY

Tau-based treatment strategies in neurodegenerative diseases

(2008) Anja Schneider et al.   Neurotherapeutics

Neuronal Differentiation Potential of Human Adipose-Derived Mesenchymal Stem Cells

(2008) Elena Anghileri et al.   STEM CELLS AND DEVELOPMENT

Rasagiline is neuroprotective in a transgenic model of multiple system atrophy

(2007) Nadia Stefanova et al.   EXPERIMENTAL NEUROLOGY