Therapeutic Potential of Neurotrophins for Repair After Brain Injury: A Helping Hand From Biomaterials

Circulating heparan sulfate fragments mediate septic cognitive dysfunction

(2019) Joseph A. Hippensteel et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study

(2019) Marta Sacchetti et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Nerve Growth Factor: Early Studies And Recent Clinical Trials

(2018) Maria Luisa Rocco et al.   Current Neuropharmacology

Phase 2 Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis

(2018) Stefano Bonini et al.   OPHTHALMOLOGY

Retention of the Structure and Function of Heparan Sulfate Biomaterials After Gamma Irradiation

(2018) Raymond A.A. Smith et al.   TISSUE ENGINEERING PART A

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Nerve growth factor: a neuroimmune crosstalk mediator for all seasons

(2017) Stephen D. Skaper   IMMUNOLOGY

Targeting Neurotrophins to Specific Populations of Neurons: NGF, BDNF, and NT-3 and Their Relevance for Treatment of Spinal Cord Injury

(2017) Kathleen Keefe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Agreed definitions and a shared vision for new standards in stroke recovery research: The Stroke Recovery and Rehabilitation Roundtable taskforce

(2017) Julie Bernhardt et al.   International Journal of Stroke

Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group

(2017) Dale Corbett et al.   International Journal of Stroke

Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke

(2017) James E Orfila et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain

(2017) Juan Pablo Zanin et al.   JOURNAL OF NEUROCHEMISTRY

Endogenous regeneration: Engineering growth factors for stroke

(2017) Su Jing Chan et al.   NEUROCHEMISTRY INTERNATIONAL

Combinatorial Therapies After Spinal Cord Injury: How Can Biomaterials Help?

(2017) Tobias Führmann et al.   Advanced Healthcare Materials

Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate

(2016) Barbara Mulloy et al.   ANALYTICAL CHEMISTRY

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

(2016) Daniel Santos et al.   BRAIN RESEARCH

Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment

(2016) Susan M. Carnachan et al.   CARBOHYDRATE POLYMERS

Affinity Selection of FGF2-Binding Heparan Sulfates for Ex Vivo Expansion of Human Mesenchymal Stem Cells

(2016) Sampath Jeewantha Wijesinghe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke

(2016) Douglas J Cook et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of ischemia on the expression of neurotrophins and their receptors in rat brain structures outside the lesion site, including on the opposite hemisphere

(2016) V. G. Dmitrieva et al.   MOLECULAR BIOLOGY

Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications

(2015) Peter C. Tyler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke

(2015) Denise A. Duricki et al.   BRAIN

Executive Summary: Heart Disease and Stroke Statistics—2015 Update:

(2015) Dariush Mozaffarian et al.   CIRCULATION

Combined Ampakine and BDNF Treatments Enhance Poststroke Functional Recovery in Aged Mice via AKT-CREB Signaling

(2015) Andrew N Clarkson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotection for ischaemic stroke: Current status and challenges

(2015) Antonio Moretti et al.   PHARMACOLOGY & THERAPEUTICS

Demystifying Heparan Sulfate–Protein Interactions

(2014) Ding Xu et al.   Annual Review of Biochemistry

Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

(2014) Chunming Wang et al.   BIOMATERIALS

The Experimental Therapy on Brain Ischemia by Improvement of Local Angiogenesis with Tissue Engineering in the Mouse

(2014) Rongkai Ju et al.   CELL TRANSPLANTATION

Post-stroke recovery: the role of activity-dependent release of brain-derived neurotrophic factor

(2014) Antonio Berretta et al.   Expert Review of Neurotherapeutics

An Adaptive Role for BDNF Val66Met Polymorphism in Motor Recovery in Chronic Stroke

(2014) L. Qin et al.   JOURNAL OF NEUROSCIENCE

GSK-3/CREB pathway involved in the gx-50's effect on Alzheimer's disease

(2014) Maoping Tang et al.   NEUROPHARMACOLOGY

Vector-induced NT-3 expression in rats promotes collateral growth of injured corticospinal tract axons far rostral to a spinal cord injury

(2014) N. Weishaupt et al.   NEUROSCIENCE

Effects of GDNF-Loaded Injectable Gelatin-Based Hydrogels on Endogenous Neural Progenitor Cell Migration

(2014) Deniece Fon et al.   Advanced Healthcare Materials

Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases

(2014) Junying Cai et al.   Biomed Research International

Affinity-selected heparan sulfate for bone repair

(2013) S. Murali et al.   BIOMATERIALS

Biomaterial-based drug delivery systems for the controlled release of neurotrophic factors

(2013) Nima Khadem Mohtaram et al.   Biomedical Materials

Alteration in BDNF and its receptors, full-length and truncated TrkB and p75NTR following penetrating traumatic brain injury

(2013) Elham Rostami et al.   BRAIN RESEARCH

Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains

(2013) P. L. DeAngelis et al.   GLYCOBIOLOGY

Multimodal Examination of Structural and Functional Remapping in the Mouse Photothrombotic Stroke Model

(2013) Andrew N Clarkson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Approaches for Neural Tissue Regeneration

(2013) Loïc Binan et al.   Stem Cell Reviews and Reports

Perlecan Domain V Is Neuroprotective and Affords Functional Improvement in a Photothrombotic Stroke Model in Young and Aged Mice

(2013) Gregory J. Bix et al.   Translational Stroke Research

Cooperative effect of heparan sulfate and laminin mimetic peptide nanofibers on the promotion of neurite outgrowth

(2012) Busra Mammadov et al.   Acta Biomaterialia

Repairing rat sciatic nerve injury by a nerve-growth-factor-loaded, chitosan-based nerve conduit

(2012) Hongkui Wang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation

(2012) Kelli G. Sharp et al.   EXPERIMENTAL NEUROLOGY

Neurotrophins and their role in the cochlea

(2012) Dyan Ramekers et al.   HEARING RESEARCH

Synthesis and characterization of electrospun polyvinyl alcohol nanofibrous scaffolds modified by blending with chitosan for neural tissue engineering

(2012) Masoud Mozafari et al.   International Journal of Nanomedicine

Chitosan/gelatin porous scaffolds containing hyaluronic acid and heparan sulfate for neural tissue engineering

(2012) Shui Guan et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

BDNF −270 C>T polymorphisms might be associated with stroke type and BDNF −196 G>A corresponds to early neurological deficit in hemorrhagic stroke

(2012) Dagmara Mirowska-Guzel et al.   JOURNAL OF NEUROIMMUNOLOGY

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

(2012) Dirk M Hermann et al.   LANCET NEUROLOGY

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

(2012) Nicola J. Allen et al.   NATURE

ProBDNF Collapses Neurite Outgrowth of Primary Neurons by Activating RhoA

(2012) Ying Sun et al.   PLoS One

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke

(2012) J. J. Overman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracerebral chondroitinase ABC and heparan sulfate proteoglycan glypican improve outcome from chronic stroke in rats

(2012) J. J. Hill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal Outgrowth and Dendritic Plasticity in the Cortical Peri-Infarct Area After Experimental Stroke

(2012) Yuji Ueno et al.   STROKE

Design and Fabrication of a Biodegradable, Covalently Crosslinked Shape-Memory Alginate Scaffold for Cell and Growth Factor Delivery

(2012) Lin Wang et al.   TISSUE ENGINEERING PART A

Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment

(2011) Xu Jiang et al.   Acta Biomaterialia

Neuronal regeneration and protection by collagen-binding BDNF in the rat middle cerebral artery occlusion model

(2011) Jian Guan et al.   BIOMATERIALS

The administration of BDNF and GDNF to the brain via PLGA microparticles patterned within a degradable PEG-based hydrogel: Protein distribution and the glial response

(2011) Kyle J. Lampe et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Neural regrowth induced by PLGA nerve conduits and neurotrophin-3 in rats with complete spinal cord transection

(2011) Juan Fan et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin

(2011) Maxim M. Bespalov et al.   JOURNAL OF CELL BIOLOGY

Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents

(2011) Boyeon Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPA Receptor-Induced Local Brain-Derived Neurotrophic Factor Signaling Mediates Motor Recovery after Stroke

(2011) A. N. Clarkson et al.   JOURNAL OF NEUROSCIENCE

The Role of the Met66 Brain-Derived Neurotrophic Factor Allele in the Recovery of Executive Functioning after Combat-Related Traumatic Brain Injury

(2011) F. Krueger et al.   JOURNAL OF NEUROSCIENCE

Rat sciatic nerve repair with a poly-lactic-co-glycolic acid scaffold and nerve growth factor releasing microspheres

(2011) Ralph de Boer et al.   MICROSURGERY

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

(2011) K. Deinhardt et al.   Science Signaling

Thermal Stability of Fibroblast Growth Factor Protein Is a Determinant Factor in Regulating Self-Renewal, Differentiation, and Reprogramming in Human Pluripotent Stem Cells

(2011) Guokai Chen et al.   STEM CELLS

Current trends in stroke rehabilitation. A review with focus on brain plasticity

(2010) B. B. Johansson   ACTA NEUROLOGICA SCANDINAVICA

Tissue engineering for clinical applications

(2010) Sujata K. Bhatia   Biotechnology Journal

Brain self-protection: The role of endogenous neural progenitor cells in adult brain after cerebral cortical ischemia

(2010) Bin Li et al.   BRAIN RESEARCH

Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease

(2010) Akira Yoshii et al.   Developmental Neurobiology

Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae

(2010) Seiji B. Shibata et al.   EXPERIMENTAL NEUROLOGY

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides

(2010) Renpeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vitro and in vivo release of nerve growth factor from biodegradable poly-lactic-co-glycolic-acid microspheres

(2010) Ralph de Boer et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Peripheral nerve regeneration using composite poly(lactic acid-caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning

(2010) Jun-Jian Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Growth factors in ischemic stroke

(2010) S. Lanfranconi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

(2010) Andrew N. Clarkson et al.   NATURE

An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke

(2010) Songlin Li et al.   NATURE NEUROSCIENCE

Functions of Nogo proteins and their receptors in the nervous system

(2010) Martin E. Schwab   NATURE REVIEWS NEUROSCIENCE

Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats

(2010) Yannick Béjot et al.   NEUROCHEMISTRY INTERNATIONAL

Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning

(2010) Brita Fritsch et al.   NEURON

Polycaprolactone and Bovine Serum Albumin Based Nanofibers for Controlled Release of Nerve Growth Factor

(2009) Chandra M. Valmikinathan et al.   BIOMACROMOLECULES

Complex Formation of a Brain-Derived Neurotrophic Factor and Glycosaminoglycans

(2009) Yukihiro KANATO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

(2009) Emily G. Waterhouse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Promoting axonal rewiring to improve outcome after stroke

(2009) Larry I. Benowitz et al.   NEUROBIOLOGY OF DISEASE

Forebrain neurogenesis after focal Ischemic and traumatic brain injury

(2009) Steven G. Kernie et al.   NEUROBIOLOGY OF DISEASE

Using Polymer Chemistry to Modulate the Delivery of Neurotrophic Factors from Degradable Microspheres: Delivery of BDNF

(2009) James P. Bertram et al.   PHARMACEUTICAL RESEARCH

Three-Dimensional Nanofibrous Scaffolds Incorporating Immobilized BDNF Promote Proliferation and Differentiation of Cortical Neural Stem Cells

(2009) Malcolm K. Horne et al.   STEM CELLS AND DEVELOPMENT

Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats

(2009) Michelle Ploughman et al.   STROKE

Effects of Immobilized Glycosaminoglycans on the Proliferation and Differentiation of Mesenchymal Stem Cells

(2009) Basak E. Uygun et al.   TISSUE ENGINEERING PART A

The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels

(2008) Yukie Aizawa et al.   BIOMATERIALS

The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages

(2008) Jingwei Xie et al.   BIOMATERIALS

Glypican-3 Inhibits Hedgehog Signaling during Development by Competing with Patched for Hedgehog Binding

(2008) Mariana I. Capurro et al.   DEVELOPMENTAL CELL

Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model

(2008) Seung-Wan Yoo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Direct binding of polysialic acid to a brain-derived neurotrophic factor depends on the degree of polymerization

(2008) Yukihiro Kanato et al.   GLYCOBIOLOGY

Heparan Sulfate Mediates the Proliferation and Differentiation of Rat Mesenchymal Stem Cells

(2008) Christian Dombrowski et al.   STEM CELLS AND DEVELOPMENT