Synucleins and Gene Expression: Ramblers in a Crowd or Cops Regulating Traffic?

Role of Advanced Glycation on Aggregation and DNA Binding Properties of α-Synuclein

(2018) Vasudevaraju Padmaraju et al.   JOURNAL OF ALZHEIMERS DISEASE

FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells

(2017) Ismael Segura-Ulate et al.   NEUROPHARMACOLOGY

Synucleins Have Multiple Effects on Presynaptic Architecture

(2017) Karina J. Vargas et al.   Cell Reports

Pore-Forming Proteins as Mediators of Novel Epigenetic Mechanism of Epilepsy

(2017) Andrei Surguchov et al.   Frontiers in Neurology

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons

(2017) Chee Yeun Chung et al.   Cell Systems

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

(2017) Vikram Khurana et al.   Cell Systems

Protein-DNA Interaction at the Origin of Neurological Diseases: A Hypothesis

(2017) Juan S. Jiménez   JOURNAL OF ALZHEIMERS DISEASE

Histones facilitate α-synuclein aggregation during neuronal apoptosis

(2016) Peizhou Jiang et al.   ACTA NEUROPATHOLOGICA

The yin and yang of α-synuclein-associated epigenetics in Parkinson’s disease

(2016) Maria Angeliki S. Pavlou et al.   BRAIN

Alpha-synuclein structure, functions, and interactions

(2016) FatemehNouri Emamzadeh   Journal of Research in Medical Sciences

Identification of gamma-synuclein as a new PCBP1-interacting protein

(2016) Amanda Hunkele et al.   NEUROLOGICAL RESEARCH

α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses

(2016) Naoto Sugeno et al.   Scientific Reports

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

(2016) James W. P. Brown et al.   Scientific Reports

 -synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons

(2015) M. Zaltieri et al.   JOURNAL OF CELL SCIENCE

L-dopa increasesα-synuclein DNA methylation in Parkinson's disease patientsin vivoandin vitro

(2015) Ina Schmitt et al.   MOVEMENT DISORDERS

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

(2015) Paula Garcia-Esparcia et al.   Acta Neuropathologica Communications

α-Synuclein is Prone to Interaction with the GC-Box-Like Sequence In Vitro

(2014) Kai-Li Ma et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

From yeast to patient neurons and back again: Powerful new discovery platforms

(2014) Daniel F. Tardiff et al.   MOVEMENT DISORDERS

Differential involvement of the gamma-synuclein in cognitive abilities on the model of knockout mice

(2013) Viktor S Kokhan et al.   BMC NEUROSCIENCE

Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress

(2013) Sasuk Kim et al.   EXPERIMENTAL NEUROLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein

(2013) Andreas Zanzoni et al.   NUCLEIC ACIDS RESEARCH

Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients

(2013) Yu-yan Tan et al.   PARKINSONISM & RELATED DISORDERS

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia

(2012) Shinsuke Fujioka et al.   ACTA NEUROPATHOLOGICA

Selection of DNA Aptamers That Recognize α-Synuclein Oligomers Using a Competitive Screening Method

(2012) Kaori Tsukakoshi et al.   ANALYTICAL CHEMISTRY

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson’s disease

(2012) Almas Siddiqui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses

(2012) Natalia Ninkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

(2012) Jeffrey D Martell et al.   NATURE BIOTECHNOLOGY

Neurodegenerative diseases: Quantitative predictions of protein-RNA interactions

(2012) D. Cirillo et al.   RNA

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

(2011) Marie-Christine Chartier-Harlin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family

(2011) S. Anwar et al.   JOURNAL OF NEUROSCIENCE

 -Synuclein Negatively Regulates Protein Kinase C  Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

(2011) H. Jin et al.   JOURNAL OF NEUROSCIENCE

ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data

(2011) A. Lan et al.   NUCLEIC ACIDS RESEARCH

Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease

(2011) Arianna Bellucci et al.   PLoS One

Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease

(2011) Madalena Martins et al.   PLoS One

Screening of DNA aptamer which binds to α-synuclein

(2010) Kaori Tsukakoshi et al.   BIOTECHNOLOGY LETTERS

Aberrant RNA processing events in neurological disorders

(2010) Karen Anthony et al.   BRAIN RESEARCH

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

(2010) Vikram Khurana et al.   NATURE REVIEWS NEUROSCIENCE

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Endoplasmic Reticulum Protein Quality Control in Neurodegenerative Disease: The Good, the Bad and the Therapy

(2009) Wiep Scheper et al.   CURRENT MEDICINAL CHEMISTRY

DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

(2009) Muralidhar et al.   Frontiers in Bioscience-Landmark

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

(2009) Esti Yeger-Lotem et al.   NATURE GENETICS

Nervous yeast: modeling neurotoxic cell death

(2009) Ralf J. Braun et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effect of γ-Synuclein Silencing on Apoptotic Pathways in Retinal Ganglion Cells

(2008) Irina Surgucheva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Synuclein: Cell-Type-Specific Promoter Activity and Binding to Transcription Factors

(2008) Irina Surgucheva et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial fragmentation in neurodegeneration

(2008) Andrew B. Knott et al.   NATURE REVIEWS NEUROSCIENCE