The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model

(2017) E Lauretti et al.   Translational Psychiatry

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

(2017) Edith G. McGeer et al.   JOURNAL OF ALZHEIMERS DISEASE

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

(2016) Cyril Laurent et al.   BRAIN

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options

(2016) Ruth Lamb et al.   Current Treatment Options in Neurology

Progressive tauopathy in P301S tau transgenic mice is associated with a functional deficit of the olfactory system

(2016) Sujeong Yang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy

(2015) Phillip F. Giannopoulos et al.   BIOLOGICAL PSYCHIATRY

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles

(2014) Jian-Guo Li et al.   ANNALS OF NEUROLOGY

Absence of ALOX5 gene prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease

(2014) Y. B. Joshi et al.   HUMAN MOLECULAR GENETICS

Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's disease

(2013) P F Giannopoulos et al.   MOLECULAR PSYCHIATRY

5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of alzheimer disease

(2012) Jin Chu et al.   ANNALS OF NEUROLOGY

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

(2012) Jin Chu et al.   Molecular Neurodegeneration

Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model

(2011) Jin Chu et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo

(2010) Jin Chu et al.   ANNALS OF NEUROLOGY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL