PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi

Host-specific functional compartmentalization within the oligopeptide transporter during the Borrelia burgdorferi enzootic cycle

(2021) Ashley M. Groshong et al.   PLoS Pathogens

DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity

(2021) William K. Boyle et al.   PLoS Pathogens

High-resolution crystal structure of the Borreliella burgdorferi PlzA protein in complex with c-di-GMP: new insights into the interaction of c-di-GMP with the novel xPilZ domain

(2021) Avinash Singh et al.   Pathogens and Disease

Improved protein structure prediction using predicted interresidue orientations

(2020) Jianyi Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DksA plays an essential role in regulating the virulence of Borrelia burgdorferi

(2020) Charlotte Mason et al.   MOLECULAR MICROBIOLOGY

Interactions between Borrelia burgdorferi and ticks

(2020) Cheyne Kurokawa et al.   NATURE REVIEWS MICROBIOLOGY

Borrelia burgdorferi spatiotemporal regulation of transcriptional regulator bosR and decorin binding protein during murine infection

(2020) Elizabeth P. Saputra et al.   Scientific Reports

Role of HK2 in the Enzootic Cycle of Borrelia burgdorferi

(2020) Qiang Liu et al.   Frontiers in Medicine

Effect of PlzD, a YcgR homologue of c-di-GMP-binding protein, on polar flagellar motility in Vibrio alginolyticus

(2019) Seiji Kojima et al.   JOURNAL OF BIOCHEMISTRY

Emerging paradigms for PilZ domain-mediated C-di-GMP signaling

(2019) Qing Wei Cheang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector

(2019) James P. Phelan et al.   PLoS Pathogens

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

(2019) Melissa J. Caimano et al.   Frontiers in Microbiology

Structural conservation and diversity of PilZ-related domains

(2019) Michael Y. Galperin et al.   JOURNAL OF BACTERIOLOGY

Structural insights into the signalling mechanisms of two-component systems

(2018) Françoise Jacob-Dubuisson et al.   NATURE REVIEWS MICROBIOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

The Borrelia burgdorferi c-di-GMP Binding Receptors, PlzA and PlzB, Are Functionally Distinct

(2018) Jessica L. Kostick-Dunn et al.   Frontiers in Cellular and Infection Microbiology

Vital Signs: Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004–2016

(2018) Ronald Rosenberg et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Positive and Negative Regulation of Glycerol Utilization by the c-di-GMP Binding Protein PlzA in Borrelia burgdorferi

(2018) Jun-Jie Zhang et al.   JOURNAL OF BACTERIOLOGY

PP4397/FlgZ provides the link between PP2258 c-di-GMP signalling and altered motility in Pseudomonas putida

(2018) Lisa Wirebrand et al.   Scientific Reports

Bacteria, Rev Your Engines: Stator Dynamics Regulate Flagellar Motility

(2017) Amy E. Baker et al.   JOURNAL OF BACTERIOLOGY

BosR Is A Novel Fur Family Member Responsive to Copper and Regulating Copper Homeostasis in Borrelia burgdorferi

(2017) Peng Wang et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP: second messenger extraordinaire

(2017) Urs Jenal et al.   NATURE REVIEWS MICROBIOLOGY

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi , the Lyme Disease Spirochete

(2017) Arianna P. Grove et al.   mBio

ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

(2017) D. Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Interaction of the Lyme disease spirochete with its tick vector

(2016) Melissa J. Caimano et al.   CELLULAR MICROBIOLOGY

Molecular Mechanisms of Two-Component Signal Transduction

(2016) Christopher P. Zschiedrich et al.   JOURNAL OF MOLECULAR BIOLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Deciphering conformational transitions of proteins by small angle X-ray scattering and normal mode analysis

(2016) Alejandro Panjkovich et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Structures of the activator ofK. pneumoniabiofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding

(2016) Maria A. Schumacher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Different Virulence-Related Regulatory Pathways in Borrelia burgdorferi Are Directly Affected by Osmotic Fluxes in the Blood Meal of Feeding Ixodes Ticks

(2016) Sébastien Bontemps-Gallo et al.   PLoS Pathogens

The PilZ domain of MrkH represents a novel DNA binding motif

(2016) Feng Wang et al.   Protein & Cell

Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions

(2016) Katherine L. Mallory et al.   Pathogens and Disease

Lyme borreliosis

(2016) Allen C. Steere et al.   Nature Reviews Disease Primers

Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease

(2015) MD A. Motaleb et al.   CURRENT OPINION IN MICROBIOLOGY

Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission

(2015) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

Diversity of Cyclic Di-GMP-Binding Proteins and Mechanisms

(2015) Shan-Ho Chou et al.   JOURNAL OF BACTERIOLOGY

Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding

(2015) William J. Bauer et al.   JOURNAL OF STRUCTURAL BIOLOGY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

I-TASSER server: new development for protein structure and function predictions

(2015) Jianyi Yang et al.   NUCLEIC ACIDS RESEARCH

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation

(2014) Radha Iyer et al.   MOLECULAR MICROBIOLOGY

Population Bottlenecks during the Infectious Cycle of the Lyme Disease Spirochete Borrelia burgdorferi

(2014) Ryan O. M. Rego et al.   PLoS One

Regulatory Protein BBD18 of the Lyme Disease Spirochete: Essential Role During Tick Acquisition?

(2014) B. M. Hayes et al.   mBio

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi

(2014) Elizabeth A. Novak et al.   Frontiers in Cellular and Infection Microbiology

Study of the Response Regulator Rrp1 Reveals Its Regulatory Role in Chitobiose Utilization and Virulence of Borrelia burgdorferi

(2013) Ching Wooen Sze et al.   INFECTION AND IMMUNITY

Understanding Barriers to Borrelia burgdorferi Dissemination during Infection Using Massively Parallel Sequencing

(2013) Erin B. Troy et al.   INFECTION AND IMMUNITY

Cyclic Di-GMP Receptor PlzA Controls Virulence Gene Expression through RpoS in Borrelia burgdorferi

(2013) Ming He et al.   INFECTION AND IMMUNITY

Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

(2013) U. Romling et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The Unique Paradigm of Spirochete Motility and Chemotaxis

(2012) Nyles W. Charon et al.   Annual Review of Microbiology

Synthesis and Characterization of a Fluorescent Analogue of Cyclic di-GMP

(2012) Indra Mani Sharma et al.   BIOCHEMISTRY

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi

(2012) Zhiming Ouyang et al.   BMC MICROBIOLOGY

Borrelia burgdorferi Needs Chemotaxis To Establish Infection in Mammals and To Accomplish Its Enzootic Cycle

(2012) Ching Wooen Sze et al.   INFECTION AND IMMUNITY

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

(2012) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Borrelia burgdorferi Requires the Alternative Sigma Factor RpoS for Dissemination within the Vector during Tick-to-Mammal Transmission

(2012) Star M. Dunham-Ems et al.   PLoS Pathogens

Analysis of the Borrelia burgdorferi Cyclic-di-GMP-Binding Protein PlzA Reveals a Role in Motility and Virulence

(2011) Joshua E. Pitzer et al.   INFECTION AND IMMUNITY

Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi

(2011) Syed Z. Sultan et al.   INFECTION AND IMMUNITY

The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

(2011) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

Regulation of the Virulence Determinant OspC by bbd18 on Linear Plasmid lp17 of Borrelia burgdorferi

(2011) A. Sarkar et al.   JOURNAL OF BACTERIOLOGY

Multiplex PCR as a tool for validating plasmid content of Borrelia burgdorferi

(2011) Ignas Bunikis et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes

(2011) Jessica L. Kostick et al.   MOLECULAR MICROBIOLOGY

A Novel Tetrameric PilZ Domain Structure from Xanthomonads

(2011) Tso-Ning Li et al.   PLoS One

Borrelia burgdorferi Requires Glycerol for Maximum Fitness During The Tick Phase of the Enzootic Cycle

(2011) Christopher J. Pappas et al.   PLoS Pathogens

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks

(2011) Ming He et al.   PLoS Pathogens

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression

(2011) Jonathan J. Wilksch et al.   PLoS Pathogens

Gene Regulation inBorrelia burgdorferi

(2010) D. Scott Samuels   Annual Review of Microbiology

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence

(2010) Syed Z. Sultan et al.   MOLECULAR MICROBIOLOGY

FoXS: a web server for rapid computation and fitting of SAXS profiles

(2010) D. Schneidman-Duhovny et al.   NUCLEIC ACIDS RESEARCH

The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission

(2010) R. D. Gilmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Acetyl-Phosphate in Activation of the Rrp2-RpoN-RpoS Pathway in Borrelia burgdorferi

(2010) Haijun Xu et al.   PLoS Pathogens

Borrelia burgdorferi bba74 Is Expressed Exclusively during Tick Feeding and Is Regulated by Both Arthropod- and Mammalian Host-Specific Signals

(2009) V. B. Mulay et al.   JOURNAL OF BACTERIOLOGY

Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks

(2009) Star M. Dunham-Ems et al.   JOURNAL OF CLINICAL INVESTIGATION

BosR (BB0647) governs virulence expression in Borrelia burgdorferi

(2009) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete

(2009) Jenny A. Hyde et al.   MOLECULAR MICROBIOLOGY

Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator ofBorrelia burgdorfericore cellular functions

(2009) Elizabeth A. Rogers et al.   MOLECULAR MICROBIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Essential Role of the Response Regulator Rrp2 in the Infectious Cycle of Borrelia burgdorferi

(2008) B. K. Boardman et al.   INFECTION AND IMMUNITY

Biology of Infection with Borrelia burgdorferi

(2008) Kit Tilly et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA