Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger

Biofilm infections, their resilience to therapy and innovative treatment strategies

(2013) U. Römling et al.   JOURNAL OF INTERNAL MEDICINE

Visualizing the Perturbation of Cellular Cyclic di-GMP Levels in Bacterial Cells

(2013) Chun Loong Ho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered Allosteric Ribozymes That Sense the Bacterial Second Messenger Cyclic Diguanosyl 5′-Monophosphate

(2012) Hongzhou Gu et al.   ANALYTICAL CHEMISTRY

Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation

(2012) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa

(2012) Morten T. Rybtke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Nitric Oxide Regulation of Cyclic di-GMP Synthesis and Hydrolysis in Shewanella woodyi

(2012) Niu Liu et al.   BIOCHEMISTRY

Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence

(2012) Bryan W. Davies et al.   CELL

You’ve come a long way: c-di-GMP signaling

(2012) Holger Sondermann et al.   CURRENT OPINION IN MICROBIOLOGY

Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein–protein interaction

(2012) Samuel Steiner et al.   EMBO JOURNAL

Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

(2012) Songying Ouyang et al.   IMMUNITY

Cyclic Di-GMP Stimulates Biofilm Formation and Inhibits Virulence of Francisella novicida

(2012) Xhavit Zogaj et al.   INFECTION AND IMMUNITY

Exposure of Salmonella enterica Serovar Typhimurium to a Protective Monoclonal IgA Triggers Exopolysaccharide Production via a Diguanylate Cyclase-Dependent Pathway

(2012) Jayaleka J. Amarasinghe et al.   INFECTION AND IMMUNITY

A Tangled Web: Regulatory Connections between Quorum Sensing and Cyclic Di-GMP

(2012) D. Srivastava et al.   JOURNAL OF BACTERIOLOGY

Sticky Situations: Key Components That Control Bacterial Surface Attachment

(2012) O. E. Petrova et al.   JOURNAL OF BACTERIOLOGY

Evidence for Cyclic Di-GMP-Mediated Signaling in Bacillus subtilis

(2012) Yun Chen et al.   JOURNAL OF BACTERIOLOGY

Cyclic Diguanylate Inversely Regulates Motility and Aggregation in Clostridium difficile

(2012) E. B. Purcell et al.   JOURNAL OF BACTERIOLOGY

Structural Insights into the Regulatory Mechanism of the Response Regulator RocR from Pseudomonas aeruginosa in Cyclic Di-GMP Signaling

(2012) Ming Wei Chen et al.   JOURNAL OF BACTERIOLOGY

Type IV Pilus Assembly in Pseudomonas aeruginosa over a Broad Range of Cyclic di-GMP Concentrations

(2012) R. Jain et al.   JOURNAL OF BACTERIOLOGY

Coordinated Cyclic-Di-GMP Repression of Salmonella Motility through YcgR and Cellulose

(2012) V. Zorraquino et al.   JOURNAL OF BACTERIOLOGY

Minor Pilins of the Type IV Pilus System Participate in the Negative Regulation of Swarming Motility

(2012) S. L. Kuchma et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-GMP Phosphodiesterases RmdA and RmdB Are Involved in Regulating Colony Morphology and Development in Streptomyces coelicolor

(2012) T. D. Hull et al.   JOURNAL OF BACTERIOLOGY

Structural Characterization of a Conserved, Calcium-Dependent Periplasmic Protease from Legionella pneumophila

(2012) D. Chatterjee et al.   JOURNAL OF BACTERIOLOGY

The Phosphodiesterase DipA (PA5017) Is Essential for Pseudomonas aeruginosa Biofilm Dispersion

(2012) A. B. Roy et al.   JOURNAL OF BACTERIOLOGY

DarR, a TetR-like Transcriptional Factor, Is a Cyclic Di-AMP-responsive Repressor inMycobacterium smegmatis

(2012) Lei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production inPseudomonas aeruginosa

(2012) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel capture compound for the identification and analysis of cyclic di-GMP binding proteins

(2012) Jutta Nesper et al.   Journal of Proteomics

A full-length bifunctional protein involved in c-di-GMP turnover is required for long-term survival under nutrient starvation in Mycobacterium smegmatis

(2012) B. K. Bharati et al.   MICROBIOLOGY-SGM

A C-di-GMP–proflavine–hemin supramolecular complex has peroxidase activity—implication for a simple colorimetric detection

(2012) Shizuka Nakayama et al.   Molecular BioSystems

Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

(2012) Qian Yin et al.   MOLECULAR CELL

Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network

(2012) Lars Plate et al.   MOLECULAR CELL

YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex

(2012) Akiko Takaya et al.   MOLECULAR MICROBIOLOGY

The orphan histidine protein kinase SgmT is a c-di-GMP receptor and regulates composition of the extracellular matrix together with the orphan DNA binding response regulator DigR in Myxococcus xanthus

(2012) Tobias Petters et al.   MOLECULAR MICROBIOLOGY

Retracted: Dynamic complex formation between HD-GYP, GGDEF and PilZ domain proteins regulates motility inXanthomonas campestris

(2012) Robert P. Ryan et al.   MOLECULAR MICROBIOLOGY

Light-induced alteration of c-di-GMP level controls motility of Synechocystis sp. PCC 6803

(2012) Philipp Savakis et al.   MOLECULAR MICROBIOLOGY

The response threshold ofSalmonellaPilZ domain proteins is determined by their binding affinities for c-di-GMP

(2012) Ingrid Swanson Pultz et al.   MOLECULAR MICROBIOLOGY

The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium

(2012) Zhi-hui Chen et al.   NATURE

Crystallographic snapshot of cellulose synthesis and membrane translocation

(2012) Jacob L. W. Morgan et al.   NATURE

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

(2012) Chang Shu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the sensing and binding of cyclic di-GMP by STING

(2012) Yi-He Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

(2012) Guijun Shang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility

(2012) Bingqing Li et al.   NUCLEIC ACIDS RESEARCH

LtmA, a novel cyclic di-GMP-responsive activator, broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis

(2012) Weihui Li et al.   NUCLEIC ACIDS RESEARCH

The FleQ protein from Pseudomonas aeruginosa functions as both a repressor and an activator to control gene expression from the pel operon promoter in response to c-di-GMP

(2012) C. Baraquet et al.   NUCLEIC ACIDS RESEARCH

Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP

(2012) Yinlan Bai et al.   PLoS One

RsmA Regulates Biofilm Formation in Xanthomonas campestris through a Regulatory Network Involving Cyclic di-GMP and the Clp Transcription Factor

(2012) Xiu-Hong Lu et al.   PLoS One

Dispersion by Pseudomonas aeruginosa requires an unusual posttranslational modification of BdlA

(2012) O. E. Petrova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover

(2012) Y. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantification of high-specificity cyclic diguanylate signaling

(2012) J. P. Massie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa

(2012) Y. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP

(2012) Petya Violinova Krasteva et al.   PROTEIN SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

When the PilZ don’t work: effectors for cyclic di-GMP action in bacteria

(2012) Robert P. Ryan et al.   TRENDS IN MICROBIOLOGY

Enzymatically Active and Inactive Phosphodiesterases and Diguanylate Cyclases Are Involved in Regulation of Motility or Sessility in Escherichia coli CFT073

(2012) R. R. Spurbeck et al.   mBio

The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways

(2012) Jacob G. Malone et al.   PLoS Pathogens

Cellular Levels and Binding of c-di-GMP Control Subcellular Localization and Activity of the Vibrio cholerae Transcriptional Regulator VpsT

(2012) Nicholas J. Shikuma et al.   PLoS Pathogens

Discrete Cyclic di-GMP-Dependent Control of Bacterial Predation versus Axenic Growth in Bdellovibrio bacteriovorus

(2012) Laura Hobley et al.   PLoS Pathogens

The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)2at the active site

(2011) Chao-Yu Yang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mucoid Pseudomonas aeruginosa isolates maintain the biofilm formation capacity and the gene expression profiles during the chronic lung infection of CF patients

(2011) BAOLERI LEE et al.   APMIS

Characterization of the Poly-β-1,6-N-Acetylglucosamine Polysaccharide Component of Burkholderia Biofilms

(2011) Nandadeva Yakandawala et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

(2011) Xiaoxue Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Large-Scale Production of the Immunomodulator c-di-GMP from GMP and ATP by an Enzymatic Cascade

(2011) Volker Spehr et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The sweet connection: Solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli

(2011) Charalampia-Georgia Korea et al.   BIOESSAYS

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP

(2011) Ilana Kelsey et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The bacterial second messenger c-di-GMP: mechanisms of signalling

(2011) Erez Mills et al.   CELLULAR MICROBIOLOGY

Rational Design of Fluorescent Biosensor for Cyclic di-GMP

(2011) Chun Loong Ho et al.   CHEMBIOCHEM

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

(2011) Shizuka Nakayama et al.   CHEMICAL COMMUNICATIONS

Base ionization and ligand binding: how small ribozymes and riboswitches gain a foothold in a protein world

(2011) Joseph A Liberman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis

(2011) Yaara Oppenheimer-Shaanan et al.   EMBO REPORTS

Inside the complex regulation of Pseudomonas aeruginosa chaperone usher systems

(2011) Caroline Giraud et al.   ENVIRONMENTAL MICROBIOLOGY

Cyclic diguanylate turnover mediated by the sole GGDEF/EAL response regulator in Pseudomonas putida: its role in the rhizosphere and an analysis of its target processes

(2011) Miguel A. Matilla et al.   ENVIRONMENTAL MICROBIOLOGY

The Pseudomonas aeruginosa sensor RetS switches Type III and Type VI secretion via c-di-GMP signalling

(2011) Joana A. Moscoso et al.   ENVIRONMENTAL MICROBIOLOGY

Cyclic di-GMP, an established secondary messenger still speeding up

(2011) Ute Römling   ENVIRONMENTAL MICROBIOLOGY

Poly-N-Acetyl-β-(1-6)-Glucosamine Is a Target for Protective Immunity against Acinetobacter baumannii Infections

(2011) Leticia V. Bentancor et al.   INFECTION AND IMMUNITY

Cyclic Dimeric GMP Signaling Regulates Intracellular Aggregation, Sessility, and Growth of Ehrlichia chaffeensis

(2011) Yumi Kumagai et al.   INFECTION AND IMMUNITY

Direct Evaluation of Pseudomonas aeruginosa Biofilm Mediators in a Chronic Infection Model

(2011) Matthew S. Byrd et al.   INFECTION AND IMMUNITY

Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi

(2011) Syed Z. Sultan et al.   INFECTION AND IMMUNITY

c-di-GMP protects against intranasal Acinetobacter baumannii infection in mice by chemokine induction and enhanced neutrophil recruitment

(2011) Lisa Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Interplay among Cyclic Diguanylate, HapR, and the General Stress Response Regulator (RpoS) in the Regulation of Vibrio cholerae Hemagglutinin/Protease

(2011) H. Wang et al.   JOURNAL OF BACTERIOLOGY

Integration of Cyclic di-GMP and Quorum Sensing in the Control of vpsT and aphA in Vibrio cholerae

(2011) Disha Srivastava et al.   JOURNAL OF BACTERIOLOGY

Unusual Heme-Binding PAS Domain from YybT Family Proteins

(2011) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Systematic Analysis of Diguanylate Cyclases That Promote Biofilm Formation by Pseudomonas fluorescens Pf0-1

(2011) P. D. Newell et al.   JOURNAL OF BACTERIOLOGY

Type 3 Fimbriae and Biofilm Formation Are Regulated by the Transcriptional Regulators MrkHI in Klebsiella pneumoniae

(2011) J. G. Johnson et al.   JOURNAL OF BACTERIOLOGY

EAL Domain Protein YdiV Acts as an Anti-FlhD4C2 Factor Responsible for Nutritional Control of the Flagellar Regulon in Salmonella enterica Serovar Typhimurium

(2011) T. Wada et al.   JOURNAL OF BACTERIOLOGY

Identification and Characterization of CdgB, a Diguanylate Cyclase Involved in Developmental Processes in Streptomyces coelicolor

(2011) N. T. Tran et al.   JOURNAL OF BACTERIOLOGY

Output Targets and Transcriptional Regulation by a Cyclic Dimeric GMP-Responsive Circuit in the Vibrio parahaemolyticus Scr Network

(2011) R. B. R. Ferreira et al.   JOURNAL OF BACTERIOLOGY

Brucella melitensis Cyclic di-GMP Phosphodiesterase BpdA Controls Expression of Flagellar Genes

(2011) E. Petersen et al.   JOURNAL OF BACTERIOLOGY

Cyclic Dimeric GMP-Mediated Decisions in Surface-Grown Vibrio parahaemolyticus: a Different Kind of Motile-to-Sessile Transition

(2011) M. Gomelsky   JOURNAL OF BACTERIOLOGY

CsrA Represses Translation of sdiA , Which Encodes the N -Acylhomoserine-l-Lactone Receptor of Escherichia coli, by Binding Exclusively within the Coding Region of sdiA mRNA

(2011) Helen Yakhnin et al.   JOURNAL OF BACTERIOLOGY

Role of the Biofilm Master Regulator CsgD in Cross-Regulation between Biofilm Formation and Flagellar Synthesis

(2011) H. Ogasawara et al.   JOURNAL OF BACTERIOLOGY

The Atypical Two-component Sensor Kinase Lpl0330 fromLegionella pneumophilaControls the Bifunctional Diguanylate Cyclase-Phosphodiesterase Lpl0329 to Modulate Bis-(3′-5′)-cyclic Dimeric GMP Synthesis

(2011) Mélanie Levet-Paulo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergence and Convergence in Enzyme Evolution

(2011) Michael Y. Galperin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polynucleotide Phosphorylase Activity May Be Modulated by Metabolites inEscherichia coli

(2011) Salima Nurmohamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout

(2011) Judith Habazettl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa

(2011) Juliane Düvel et al.   JOURNAL OF MICROBIOLOGICAL METHODS

NanoRNAs: A Class of Small RNAs That Can Prime Transcription Initiation in Bacteria

(2011) Bryce E. Nickels et al.   JOURNAL OF MOLECULAR BIOLOGY

Cyclic di-GMP Activation of Polynucleotide Phosphorylase Signal-Dependent RNA Processing

(2011) Jason R. Tuckerman et al.   JOURNAL OF MOLECULAR BIOLOGY

Thiazole Orange-Induced c-di-GMP Quadruplex Formation Facilitates a Simple Fluorescent Detection of This Ubiquitous Biofilm Regulating Molecule

(2011) Shizuka Nakayama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligomer Formation of the Bacterial Second Messenger c-di-GMP: Reaction Rates and Equilibrium Constants Indicate a Monomeric State at Physiological Concentrations

(2011) Martin Gentner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The overlapping host responses to bacterial cyclic dinucleotides

(2011) Ali A. Abdul-Sater et al.   MICROBES AND INFECTION

Low oxygen induces the type III secretion system in Pseudomonas aeruginosa via modulation of the small RNAs rsmZ and rsmY

(2011) J. O'Callaghan et al.   MICROBIOLOGY-SGM

N-Acetylglucosamine-dependent biofilm formation in Pectobacterium atrosepticum is cryptic and activated by elevated c-di-GMP levels

(2011) D. Perez-Mendoza et al.   MICROBIOLOGY-SGM

Regulatory Cohesion of Cell Cycle and Cell Differentiation through Interlinked Phosphorylation and Second Messenger Networks

(2011) Sören Abel et al.   MOLECULAR CELL

NanoRNAs Prime Transcription Initiation In Vivo

(2011) Seth R. Goldman et al.   MOLECULAR CELL

A multi-repeat adhesin of the phytopathogen, Pectobacterium atrosepticum, is secreted by a Type I pathway and is subject to complex regulation involving a non-canonical diguanylate cyclase

(2011) Daniel Pérez-Mendoza et al.   MOLECULAR MICROBIOLOGY

The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia

(2011) Mustafa Fazli et al.   MOLECULAR MICROBIOLOGY

Surface contact stimulates the just-in-time deployment of bacterial adhesins

(2011) Guanglai Li et al.   MOLECULAR MICROBIOLOGY

Analysis of the role of Bacillus subtilis σM in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis

(2011) Yun Luo et al.   MOLECULAR MICROBIOLOGY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Antitoxin MqsA helps mediate the bacterial general stress response

(2011) Xiaoxue Wang et al.   Nature Chemical Biology

The myriad roles of cyclic AMP in microbial pathogens: from signal to sword

(2011) Kathleen A. McDonough et al.   NATURE REVIEWS MICROBIOLOGY

Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal

(2011) Diane McDougald et al.   NATURE REVIEWS MICROBIOLOGY

NCBI Reference Sequences (RefSeq): current status, new features and genome annotation policy

(2011) K. D. Pruitt et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database

(2011) M. Punta et al.   NUCLEIC ACIDS RESEARCH

Cellulose Accumulation and a Cellulose Synthase Gene are Responsible for Cell Aggregation in the Cyanobacterium Thermosynechococcus vulcanus RKN

(2011) Yusuke Kawano et al.   PLANT AND CELL PHYSIOLOGY

Differential Control of Yersinia pestis Biofilm Formation In Vitro and in the Flea Vector by Two c-di-GMP Diguanylate Cyclases

(2011) Yi-Cheng Sun et al.   PLoS One

A Novel Tetrameric PilZ Domain Structure from Xanthomonads

(2011) Tso-Ning Li et al.   PLoS One

Salmonella Biofilm Formation on Aspergillus niger Involves Cellulose – Chitin Interactions

(2011) Maria T. Brandl et al.   PLoS One

Complex c-di-GMP Signaling Networks Mediate Transition between Virulence Properties and Biofilm Formation in Salmonella enterica Serovar Typhimurium

(2011) Irfan Ahmad et al.   PLoS One

Evaluation of the Sublingual Route for Administration of Influenza H5N1 Virosomes in Combination with the Bacterial Second Messenger c-di-GMP

(2011) Gabriel Kristian Pedersen et al.   PLoS One

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response

(2011) M. K. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bis-(3'-5')-cyclic dimeric GMP-linked quorum sensing controls swarming in Vibrio parahaemolyticus

(2011) M. J. Trimble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of differential ligand recognition by two classes of bis-(3'-5')-cyclic dimeric guanosine monophosphate-binding riboswitches

(2011) K. D. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for gene control by a natural allosteric group I ribozyme

(2011) A. G. Y. Chen et al.   RNA

Role of polynucleotide phosphorylase in sRNA function in Escherichia coli

(2011) N. De Lay et al.   RNA

Light helps bacteria make important lifestyle decisions

(2011) Mark Gomelsky et al.   TRENDS IN MICROBIOLOGY

Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice

(2011) Abdullah S. Madhun et al.   VACCINE

Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila

(2011) A. Levi et al.   mBio

The Structure of an Unconventional HD-GYP Protein from Bdellovibrio Reveals the Roles of Conserved Residues in this Class of Cyclic-di-GMP Phosphodiesterases

(2011) A. L. Lovering et al.   mBio

Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis

(2011) Marcos V. A. S. Navarro et al.   PLOS BIOLOGY

A c-di-GMP Effector System Controls Cell Adhesion by Inside-Out Signaling and Surface Protein Cleavage

(2011) Peter D. Newell et al.   PLOS BIOLOGY

c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and Phosphodiesterases

(2011) Eric Bordeleau et al.   PLoS Genetics

c-di-AMP Is a New Second Messenger in Staphylococcus aureus with a Role in Controlling Cell Size and Envelope Stress

(2011) Rebecca M. Corrigan et al.   PLoS Pathogens

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks

(2011) Ming He et al.   PLoS Pathogens

MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression

(2011) Jonathan J. Wilksch et al.   PLoS Pathogens

Ligand-Binding PAS Domains in a Genomic, Cellular, and Structural Context

(2010) Jonathan T. Henry et al.   Annual Review of Microbiology

Modulation of Pseudomonas aeruginosa Biofilm Dispersal by a Cyclic-Di-GMP Phosphodiesterase with a Putative Hypoxia-Sensing Domain

(2010) S. An et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tyrosine phosphatase TpbA controls rugose colony formation in Pseudomonas aeruginosa by dephosphorylating diguanylate cyclase TpbB

(2010) Mingming Pu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biochemical and Physiological Characterization of a BLUF Protein−EAL Protein Complex Involved in Blue Light-Dependent Degradation of Cyclic Diguanylate in the Purple BacteriumRhodopseudomonas palustris

(2010) Takuya Kanazawa et al.   BIOCHEMISTRY

Molecular analysis of type 3 fimbrial genes from Escherichia coli, Klebsiella and Citrobacter species

(2010) Cheryl-lynn Y Ong et al.   BMC MICROBIOLOGY

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity

(2010) Alex Boehm et al.   CELL

Post-transcriptional global regulation by CsrA in bacteria

(2010) Johan Timmermans et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

Engineering a novel c-di-GMP-binding protein for biofilm dispersal

(2010) Qun Ma et al.   ENVIRONMENTAL MICROBIOLOGY

TheyddV-dosoperon controls biofilm formation through the regulation of genes encoding curli fibers' subunits in aerobically growingEscherichia coli

(2010) Letizia Tagliabue et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

(2010) Herman O Sintim et al.   Future Medicinal Chemistry

Salmonella entericaSerovar Typhimurium Binds to HeLa Cells via Fim-Mediated Reversible Adhesion and Irreversible Type Three Secretion System 1-Mediated Docking

(2010) Benjamin Misselwitz et al.   INFECTION AND IMMUNITY

CdpA Is a Burkholderia pseudomallei Cyclic di-GMP Phosphodiesterase Involved in Autoaggregation, Flagellum Synthesis, Motility, Biofilm Formation, Cell Invasion, and Cytotoxicity

(2010) H. S. Lee et al.   INFECTION AND IMMUNITY

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

The Cyclic-di-GMP Phosphodiesterase BinA Negatively Regulates Cellulose-Containing Biofilms in Vibrio fischeri

(2010) C. M. Bassis et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP Signaling Regulates Invasion by Ehrlichia chaffeensis of Human Monocytes

(2010) Y. Kumagai et al.   JOURNAL OF BACTERIOLOGY

Role of MrkJ, a Phosphodiesterase, in Type 3 Fimbrial Expression and Biofilm Formation in Klebsiella pneumoniae

(2010) J. G. Johnson et al.   JOURNAL OF BACTERIOLOGY

Di-Adenosine Tetraphosphate (Ap4A) Metabolism Impacts Biofilm Formation by Pseudomonas fluorescens via Modulation of c-di-GMP-Dependent Pathways

(2010) R. D. Monds et al.   JOURNAL OF BACTERIOLOGY

Binding of Cyclic Diguanylate in the Non-catalytic EAL Domain of FimX Induces a Long-range Conformational Change

(2010) Yaning Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A liquid chromatography-coupled tandem mass spectrometry method for quantitation of cyclic di-guanosine monophosphate

(2010) Christian Spangler et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Structure of PP4397 Reveals the Molecular Basis for Different c-di-GMP Binding Modes by Pilz Domain Proteins

(2010) Junsang Ko et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases

(2010) Anatoli Tchigvintsev et al.   JOURNAL OF MOLECULAR BIOLOGY

Getting in the Loop: Regulation of Development in Caulobacter crescentus

(2010) P. D. Curtis et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The diguanylate cyclase YddV controls production of the exopolysaccharide poly-N-acetylglucosamine (PNAG) through regulation of the PNAG biosynthetic pgaABCD operon

(2010) L. Tagliabue et al.   MICROBIOLOGY-SGM

Escherichia coli K-12 YfgF is an anaerobic cyclic di-GMP phosphodiesterase with roles in cell surface remodelling and the oxidative stress response

(2010) M. M. Lacey et al.   MICROBIOLOGY-SGM

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

Systematic analysis of cyclic di-GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis

(2010) Alexander G. Bobrov et al.   MOLECULAR MICROBIOLOGY

Genetic analysis of two phosphodiesterases reveals cyclic diguanylate regulation of virulence factors in Dickeya dadantii

(2010) Xuan Yi et al.   MOLECULAR MICROBIOLOGY

Unphosphorylated CsgD controls biofilm formation in Salmonella enterica serovar Typhimurium

(2010) Katherina Zakikhany et al.   MOLECULAR MICROBIOLOGY

Genes essential for morphological development and antibiotic production in Streptomyces coelicolor are targets of BldD during vegetative growth

(2010) Chris D. Den Hengst et al.   MOLECULAR MICROBIOLOGY

A post-translational, c-di-GMP-dependent mechanism regulating flagellar motility

(2010) Xin Fang et al.   MOLECULAR MICROBIOLOGY

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

Comparative genomics of cyclic-di-GMP signalling in bacteria: post-translational regulation and catalytic activity

(2010) Aswin S.N. Seshasayee et al.   NUCLEIC ACIDS RESEARCH

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

One-Flask Syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] Thiophosphate Analogues

(2010) Barbara L. Gaffney et al.   ORGANIC LETTERS

A Blue Light-inducible Phosphodiesterase Activity in the Cyanobacterium Synechococcus elongatus

(2010) Zhen Cao et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Identification, Activity and Disulfide Connectivity of C-di-GMP Regulating Proteins in Mycobacterium tuberculosis

(2010) Kajal Gupta et al.   PLoS One

Cell-cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

(2010) R. P. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate

(2010) Jae-Sun Shin et al.   PROTEIN SCIENCE

An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

(2010) E. R. Lee et al.   SCIENCE

Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

(2010) M. Christen et al.   SCIENCE

c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response

(2010) J. J. Woodward et al.   SCIENCE

Vibrio cholerae VpsT Regulates Matrix Production and Motility by Directly Sensing Cyclic di-GMP

(2010) P. V. Krasteva et al.   SCIENCE

Engineering biofilm formation and dispersal

(2010) Thomas K. Wood et al.   TRENDS IN BIOTECHNOLOGY

The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant

(2010) Wangxue Chen et al.   VACCINE

Tyrosine phosphatase TpbA of Pseudomonas aeruginosa controls extracellular DNA via cyclic diguanylic acid concentrations

(2010) Akihiro Ueda et al.   Environmental Microbiology Reports

Specific Control of Pseudomonas aeruginosa Surface-Associated Behaviors by Two c-di-GMP Diguanylate Cyclases

(2010) J. H. Merritt et al.   mBio

A novel C-di-GMP effector linking intracellular virulence regulon to quorum sensing and hypoxia sensing

(2010) Lian-Hui Zhang   Virulence

Intermolecular interactions between HD-GYP and GGDEF domain proteins mediate virulence-related signal transduction inXanthomonas campestris

(2010) Robert P. Ryan et al.   Virulence

The EpsE Flagellar Clutch Is Bifunctional and Synergizes with EPS Biosynthesis to Promote Bacillus subtilis Biofilm Formation

(2010) Sarah B. Guttenplan et al.   PLoS Genetics

YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa

(2010) Jacob G. Malone et al.   PLoS Pathogens

Enzymatic synthesis of c-di-GMP using a thermophilic diguanylate cyclase

(2009) Feng Rao et al.   ANALYTICAL BIOCHEMISTRY

3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection

(2009) Hongbin Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Flavin Cofactor-Binding PAS Domain Regulates c-di-GMP Synthesis inAxDGC2 fromAcetobacter xylinum

(2009) Yaning Qi et al.   BIOCHEMISTRY

An Oxygen-Sensing Diguanylate Cyclase and Phosphodiesterase Couple for c-di-GMP Control

(2009) Jason R. Tuckerman et al.   BIOCHEMISTRY

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

(2009) Roy R Chaudhuri et al.   BMC GENOMICS

Bacterial nucleotide-based second messengers

(2009) Christina Pesavento et al.   CURRENT OPINION IN MICROBIOLOGY

SiaA and SiaD are essential for inducing autoaggregation as a specific response to detergent stress inPseudomonas aeruginosa

(2009) Janosch Klebensberger et al.   ENVIRONMENTAL MICROBIOLOGY

Characterization of cellulose production inEscherichia coliNissle 1917 and its biological consequences

(2009) Cláudia Monteiro et al.   ENVIRONMENTAL MICROBIOLOGY

Synergistic role of curli and cellulose in cell adherence and biofilm formation of attaching and effacingEscherichia coliand identification of Fis as a negative regulator of curli

(2009) Zeus Saldaña et al.   ENVIRONMENTAL MICROBIOLOGY

Complex regulatory network encompassing the Csr, c-di-GMP and motility systems ofSalmonellaTyphimurium

(2009) Kristina Jonas et al.   ENVIRONMENTAL MICROBIOLOGY

Cyclic di-GMP signalling controls virulence properties ofSalmonella entericaserovar Typhimurium at the mucosal lining

(2009) Agaristi Lamprokostopoulou et al.   ENVIRONMENTAL MICROBIOLOGY

Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete,Borrelia burgdorferi

(2009) John C. Freedman et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light response of Escherichia coli

(2009) N. Tschowri et al.   GENES & DEVELOPMENT

Second messenger-mediated spatiotemporal control of protein degradation regulates bacterial cell cycle progression

(2009) A. Duerig et al.   GENES & DEVELOPMENT

The Staphylococcus aureus GGDEF Domain-Containing Protein, GdpS, Influences Protein A Gene Expression in a Cyclic Diguanylic Acid-Independent Manner

(2009) F. Shang et al.   INFECTION AND IMMUNITY

Salmonella enterica Serovar Typhimurium Pathogenicity Island 1-Encoded Type III Secretion System Translocases Mediate Intimate Attachment to Nonphagocytic Cells

(2009) M. Lara-Tejero et al.   INFECTION AND IMMUNITY

The Cyclic Nucleotide Monophosphate Domain of Xanthomonas campestris Global Regulator Clp Defines a New Class of Cyclic Di-GMP Effectors

(2009) F. Tao et al.   JOURNAL OF BACTERIOLOGY

Cyclic di-GMP Allosterically Inhibits the CRP-Like Protein (Clp) of Xanthomonas axonopodis pv. citri

(2009) J. L. Leduc et al.   JOURNAL OF BACTERIOLOGY

A Role for the EAL-Like Protein STM1344 in Regulation of CsgD Expression and Motility in Salmonella enterica Serovar Typhimurium

(2009) R. Simm et al.   JOURNAL OF BACTERIOLOGY

Rationalizing the Evolution of EAL Domain-Based Cyclic di-GMP-Specific Phosphodiesterases

(2009) U. Romling   JOURNAL OF BACTERIOLOGY

Bistable Expression of CsgD in Biofilm Development of Salmonella enterica Serovar Typhimurium

(2009) N. Grantcharova et al.   JOURNAL OF BACTERIOLOGY

Cyclic-di-GMP-Binding CRP-Like Protein: a Spectacular New Role for a Veteran Signal Transduction Actor

(2009) M. Gomelsky   JOURNAL OF BACTERIOLOGY

The Functional Role of a Conserved Loop in EAL Domain-Based Cyclic di-GMP-Specific Phosphodiesterase

(2009) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Nitric Oxide Signaling in Pseudomonas aeruginosa Biofilms Mediates Phosphodiesterase Activity, Decreased Cyclic Di-GMP Levels, and Enhanced Dispersal

(2009) N. Barraud et al.   JOURNAL OF BACTERIOLOGY

YybT Is a Signaling Protein That Contains a Cyclic Dinucleotide Phosphodiesterase Domain and a GGDEF Domain with ATPase Activity

(2009) Feng Rao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains

(2009) George Minasov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PILZ Protein Structure and Interactions with PILB and the FIMX EAL Domain: Implications for Control of Type IV Pilus Biogenesis

(2009) Cristiane R. Guzzo et al.   JOURNAL OF MOLECULAR BIOLOGY

Globins Synthesize the Second Messenger Bis-(3′–5′)-Cyclic Diguanosine Monophosphate in Bacteria

(2009) Xuehua Wan et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants for the Activation and Autoinhibition of the Diguanylate Cyclase Response Regulator WspR

(2009) Nabanita De et al.   JOURNAL OF MOLECULAR BIOLOGY

The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell–Cell Signaling to Virulence Gene Expression in Xanthomonas campestris

(2009) Ko-Hsin Chin et al.   JOURNAL OF MOLECULAR BIOLOGY

Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli

(2009) N. Sommerfeldt et al.   MICROBIOLOGY-SGM

Second messenger signalling governsEscherichia colibiofilm induction upon ribosomal stress

(2009) Alex Boehm et al.   MOLECULAR MICROBIOLOGY

Co-regulation ofXanthomonas campestrisvirulence by quorum sensing and a novel two-component regulatory system RavS/RavR

(2009) Ya-Wen He et al.   MOLECULAR MICROBIOLOGY

BcsQ is an essential component of theEscherichia colicellulose biosynthesis apparatus that localizes at the bacterial cell pole

(2009) Benjamin Le Quéré et al.   MOLECULAR MICROBIOLOGY

Determination of the regulon and identification of novel mRNA targets ofPseudomonas aeruginosaRsmA

(2009) Anja Brencic et al.   MOLECULAR MICROBIOLOGY

Characterization of starvation-induced dispersion inPseudomonas putidabiofilms: genetic elements and molecular mechanisms

(2009) Morten Gjermansen et al.   MOLECULAR MICROBIOLOGY

Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase

(2009) Thomas R. M. Barends et al.   NATURE

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Structural and mechanistic determinants of c-di-GMP signalling

(2009) Tilman Schirmer et al.   NATURE REVIEWS MICROBIOLOGY

Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch

(2009) Nadia Kulshina et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of ligand binding by a c-di-GMP riboswitch

(2009) Kathryn D Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of Pseudomonas aeruginosa CupD Fimbrial Genes Is Antagonistically Controlled by RcsB and the EAL-Containing PvrR Response Regulators

(2009) Helga Mikkelsen et al.   PLoS One

LapD is a bis-(3',5')-cyclic dimeric GMP-binding protein that regulates surface attachment by Pseudomonas fluorescens Pf0-1

(2009) P. D. Newell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella

(2009) C. Solano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of the GGDEF-EAL Domain-Containing c-di-GMP Receptor FimX

(2009) Marcos V.A.S. Navarro et al.   STRUCTURE

Vibrio biofilms: so much the same yet so different

(2009) Fitnat H. Yildiz et al.   TRENDS IN MICROBIOLOGY

The developmental model of microbial biofilms: ten years of a paradigm up for review

(2009) Russell D. Monds et al.   TRENDS IN MICROBIOLOGY

c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection

(2009) Dong-Liang Hu et al.   VACCINE

Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms

(2009) Nicolas Barraud et al.   Microbial Biotechnology

Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA (PA3885)

(2009) Akihiro Ueda et al.   PLoS Pathogens

Quantitative determination of cyclic diguanosine monophosphate concentrations in nucleotide extracts of bacteria by matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry

(2008) Roger Simm et al.   ANALYTICAL BIOCHEMISTRY

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Cyclic-di-GMP Regulates Extracellular Polysaccharide Production, Biofilm Formation, and Rugose Colony Development by Vibrio vulnificus

(2008) A. Nakhamchik et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MucR, a Novel Membrane-Associated Regulator of Alginate Biosynthesis in Pseudomonas aeruginosa

(2008) I. D. Hay et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Allosteric Regulation of Histidine Kinases by Their Cognate Response Regulator Determines Cell Fate

(2008) Ralf Paul et al.   CELL

An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli

(2008) Xianxuan Zhou et al.   CELL RESEARCH

Cooperation ofSalmonellapathogenicity islands 1 and 4 is required to breach epithelial barriers

(2008) Roman G. Gerlach et al.   CELLULAR MICROBIOLOGY

Molecular motors of the bacterial flagella

(2008) Tohru Minamino et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Insights into Yersinia pestis biofilm development: topology and co-interaction of Hms inner membrane proteins involved in exopolysaccharide production

(2008) Alexander G. Bobrov et al.   ENVIRONMENTAL MICROBIOLOGY

Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures inPseudomonas aeruginosabiofilms

(2008) Kim B. Barken et al.   ENVIRONMENTAL MICROBIOLOGY

HD-GYP domain proteins regulate biofilm formation and virulence inPseudomonas aeruginosa

(2008) Robert P. Ryan et al.   ENVIRONMENTAL MICROBIOLOGY

Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli

(2008) C. Pesavento et al.   GENES & DEVELOPMENT

Role of Cyclic Di-GMP during El Tor Biotype Vibrio cholerae Infection: Characterization of the In Vivo-Induced Cyclic Di-GMP Phosphodiesterase CdpA

(2008) R. Tamayo et al.   INFECTION AND IMMUNITY

A Staphylococcal GGDEF Domain Protein Regulates Biofilm Formation Independently of Cyclic Dimeric GMP

(2008) L. M. Holland et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-GMP (c-Di-GMP) Goes in1593to Host Cells—c-Di-GMP Signaling in the Obligate Intracellular PathogenAnaplasma phagocytophilum

(2008) Ute Römling   JOURNAL OF BACTERIOLOGY

TheAnaplasma phagocytophilumPleC Histidine Kinase and PleD Diguanylate Cyclase Two-Component System and Role of Cyclic Di-GMP in Host Cell Infection

(2008) Tzung-Huei Lai et al.   JOURNAL OF BACTERIOLOGY

Identification and Characterization of Cyclic Diguanylate Signaling Systems Controlling Rugosity in Vibrio cholerae

(2008) S. Beyhan et al.   JOURNAL OF BACTERIOLOGY

Interplay between Cyclic AMP-Cyclic AMP Receptor Protein and Cyclic di-GMP Signaling in Vibrio cholerae Biofilm Formation

(2008) J. C. N. Fong et al.   JOURNAL OF BACTERIOLOGY

Quorum Sensing Controls Biofilm Formation in Vibrio cholerae through Modulation of Cyclic Di-GMP Levels and Repression of vpsT

(2008) C. M. Waters et al.   JOURNAL OF BACTERIOLOGY

Distinct Sensory Pathways in Vibrio cholerae El Tor and Classical Biotypes Modulate Cyclic Dimeric GMP Levels To Control Biofilm Formation

(2008) B. K. Hammer et al.   JOURNAL OF BACTERIOLOGY

The Anabaena sp. Strain PCC 7120 Gene all2874 Encodes a Diguanylate Cyclase and Is Required for Normal Heterocyst Development under High-Light Growth Conditions

(2008) M. R. Neunuebel et al.   JOURNAL OF BACTERIOLOGY

Catalytic Mechanism of Cyclic Di-GMP-Specific Phosphodiesterase: a Study of the EAL Domain-Containing RocR from Pseudomonas aeruginosa

(2008) F. Rao et al.   JOURNAL OF BACTERIOLOGY

Regulation ofEscherichia coliPolynucleotide Phosphorylase by ATP

(2008) Marta Del Favero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the sfaXII locus in the Escherichia coli meningitis isolate IHE3034 reveals two novel regulatory genes within the promoter-distal region of the main S fimbrial operon

(2008) Annika E. Sjöström et al.   MICROBIAL PATHOGENESIS

The post-transcriptional regulator CsrA plays a central role in the adaptation of bacterial pathogens to different stages of infection in animal hosts

(2008) C. Lucchetti-Miganeh et al.   MICROBIOLOGY-SGM

Membrane topology and roles of Pseudomonas aeruginosa Alg8 and Alg44 in alginate polymerization

(2008) L. L. Oglesby et al.   MICROBIOLOGY-SGM

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

(2008) Irene Kiburu et al.   Molecular BioSystems

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

(2008) Gregor Witte et al.   MOLECULAR CELL

Large-scale transposon mutagenesis ofMycoplasma pulmonis

(2008) Christopher T. French et al.   MOLECULAR MICROBIOLOGY

Type IV pili: e pluribus unum?

(2008) Vladimir Pelicic   MOLECULAR MICROBIOLOGY

The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins

(2008) Kristina Jonas et al.   MOLECULAR MICROBIOLOGY

Identification of FleQ fromPseudomonas aeruginosaas a c-di-GMP-responsive transcription factor

(2008) Jason W. Hickman et al.   MOLECULAR MICROBIOLOGY

The role of PilZ domain proteins in the virulence ofXanthomonas campestrispv.campestris

(2008) YVONNE MCCARTHY et al.   MOLECULAR PLANT PATHOLOGY

Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium

(2008) Klas Flärdh et al.   NATURE REVIEWS MICROBIOLOGY

Design and Synthesis ofbis-carbamate Analogs of Cyclicbis-(3′-5′)-Diguanylic Acid (c-di-GMP) and the Acyclic Dimer PGPG

(2008) Toni Kline et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

XC1028 fromXanthomonas campestrisadopts a PilZ domain-like structure without a c-di-GMP switch

(2008) Tso-Ning Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP

(2008) N. Sudarsan et al.   SCIENCE

Great Times for Small Molecules: c-di-AMP, a Second Messenger Candidate in Bacteria and Archaea

(2008) U. Romling   Science Signaling

Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development

(2008) Anjali Mandlik et al.   TRENDS IN MICROBIOLOGY

c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection

(2008) Abiodun D. Ogunniyi et al.   VACCINE