The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

Outer surface protein polymorphisms linked to host-spirochete association in Lyme borreliae

(2019) Danielle M. Tufts et al.   MOLECULAR MICROBIOLOGY

Extreme slow growth as alternative strategy to survive deep starvation in bacteria

(2019) Declan A. Gray et al.   Nature Communications

Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination

(2019) Jerilyn R. Izac et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair

(2018) Theodore B. Verhey et al.   Cell Reports

Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete

(2018) William K. Arnold et al.   PLoS One

Persistent Infection and Long-Term Carriage of Typhoidal and Nontyphoidal Salmonellae

(2018) Ohad Gal-Mor   CLINICAL MICROBIOLOGY REVIEWS

Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi

(2018) Theodore B. Verhey et al.   MOLECULAR MICROBIOLOGY

Comprehensive Spatial Analysis of the Borrelia burgdorferi Lipoproteome Reveals a Compartmentalization Bias toward the Bacterial Surface

(2017) Alexander S. Dowdell et al.   JOURNAL OF BACTERIOLOGY

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi , the Lyme Disease Spirochete

(2017) Arianna P. Grove et al.   mBio

Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter

(2017) Ashley M. Groshong et al.   mBio

Hydrophobicity of Residue 128 of the Stress-Inducible Sigma Factor RpoS Is Critical for Its Activity

(2017) Tadayuki Iwase et al.   Frontiers in Microbiology

There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes

(2017) Ashley L. Marcinkiewicz et al.   Frontiers in Microbiology

Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts

(2017) Karen E. Tracy et al.   Frontiers in Immunology

Consensus computational network analysis for identifying candidate outer membrane proteins from Borrelia spirochetes

(2016) Melisha R. Kenedy et al.   BMC MICROBIOLOGY

Interaction of the Lyme disease spirochete with its tick vector

(2016) Melissa J. Caimano et al.   CELLULAR MICROBIOLOGY

Prokaryotic toxin–antitoxin systems: novel regulations of the toxins

(2016) Yuichi Otsuka   CURRENT GENETICS

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Virulence of the Lyme disease spirochete before and after the tick bloodmeal: a quantitative assessment

(2016) Irene N. Kasumba et al.   Parasites & Vectors

Structures ofE.coliσS-transcription initiation complexes provide new insights into polymerase mechanism

(2016) Bin Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex

(2016) Brandon L. Garcia et al.   PLoS Pathogens

Lyme borreliosis

(2016) Allen C. Steere et al.   Nature Reviews Disease Primers

In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection

(2016) Jonathan T. Skare et al.   PLoS One

Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete

(2015) Yi-Pin Lin et al.   CELLULAR MICROBIOLOGY

Glycosaminoglycan binding byBorrelia burgdorferiadhesin BBK32 specifically and uniquely promotes joint colonization

(2015) Yi-Pin Lin et al.   CELLULAR MICROBIOLOGY

Extra Cytoplasmic Function sigma factors, recent structural insights into promoter recognition and regulation

(2015) Sébastien Campagne et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Borrelia burgdorferi RevA Significantly Affects Pathogenicity and Host Response in the Mouse Model of Lyme Disease

(2015) Rebecca Byram et al.   INFECTION AND IMMUNITY

Cyclic di-GMP Modulates Gene Expression in Lyme Disease Spirochetes at the Tick-Mammal Interface To Promote Spirochete Survival during the Blood Meal and Tick-to-Mammal Transmission

(2015) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

Intravital imaging of hair follicle regeneration in the mouse

(2015) Cristiana M Pineda et al.   Nature Protocols

Repressor activity of the RpoS/σS-dependent RNA polymerase requires DNA binding

(2015) Corinne Lévi-Meyrueis et al.   NUCLEIC ACIDS RESEARCH

Bacterial Sigma Factors: A Historical, Structural, and Genomic Perspective

(2014) Andrey Feklístov et al.   Annual Review of Microbiology

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation

(2014) Radha Iyer et al.   MOLECULAR MICROBIOLOGY

Global Repression of Host-Associated Genes of the Lyme Disease Spirochete through Post-Transcriptional Modulation of the Alternative Sigma Factor RpoS

(2014) Daniel P. Dulebohn et al.   PLoS One

BosR Functions as a Repressor of the ospAB Operon in Borrelia burgdorferi

(2014) Yanlin Shi et al.   PLoS One

Regulatory Protein BBD18 of the Lyme Disease Spirochete: Essential Role During Tick Acquisition?

(2014) B. M. Hayes et al.   mBio

Distribution of cp32 Prophages among Lyme Disease-Causing Spirochetes and Natural Diversity of Their Lipoprotein-EncodingerpLoci

(2013) Dustin Brisson et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation

(2013) Emmanuel F Mongodin et al.   BMC GENOMICS

Evaluation of RevA, a Fibronectin-Binding Protein of Borrelia burgdorferi, as a Potential Vaccine Candidate for Lyme Disease

(2013) Angela M. Floden et al.   Clinical and Vaccine Immunology

EDGE-pro: Estimated Degree of Gene Expression in Prokaryotic Genomes

(2013) Tanja Magoc et al.   Evolutionary Bioinformatics

Study of the Response Regulator Rrp1 Reveals Its Regulatory Role in Chitobiose Utilization and Virulence of Borrelia burgdorferi

(2013) Ching Wooen Sze et al.   INFECTION AND IMMUNITY

Borrelia burgdorferi bba66Gene Inactivation Results in Attenuated Mouse Infection by Tick Transmission

(2013) Toni G. Patton et al.   INFECTION AND IMMUNITY

Cyclic Di-GMP Receptor PlzA Controls Virulence Gene Expression through RpoS in Borrelia burgdorferi

(2013) Ming He et al.   INFECTION AND IMMUNITY

The lipoprotein La7 contributes to Borrelia burgdorferi persistence in ticks and their transmission to naïve hosts

(2013) Xiuli Yang et al.   MICROBES AND INFECTION

Borrelia burgdorferioxidative stress regulator BosR directly represses lipoproteins primarily expressed in the tick during mammalian infection

(2013) Peng Wang et al.   MOLECULAR MICROBIOLOGY

Borreliahost adaptation Regulator (BadR) regulatesrpoSto modulate host adaptation and virulence factors inBorrelia burgdorferi

(2013) Christine L. Miller et al.   MOLECULAR MICROBIOLOGY

Lipoprotein succession inBorrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection

(2013) Kit Tilly et al.   MOLECULAR MICROBIOLOGY

An Inverted Repeat in the ospC Operator Is Required for Induction in Borrelia burgdorferi

(2013) Dan Drecktrah et al.   PLoS One

HrpA, an RNA Helicase Involved in RNA Processing, Is Required for Mouse Infectivity and Tick Transmission of the Lyme Disease Spirochete

(2013) Aydan Salman-Dilgimen et al.   PLoS Pathogens

The Unique Paradigm of Spirochete Motility and Chemotaxis

(2012) Nyles W. Charon et al.   Annual Review of Microbiology

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi

(2012) Zhiming Ouyang et al.   BMC MICROBIOLOGY

Rrp2, a Prokaryotic Enhancer-Like Binding Protein, Is Essential for Viability of Borrelia burgdorferi

(2012) A. M. Groshong et al.   JOURNAL OF BACTERIOLOGY

Two CheW coupling proteins are essential in a chemosensory pathway of Borrelia burgdorferi

(2012) Kai Zhang et al.   MOLECULAR MICROBIOLOGY

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

(2012) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Genome Stability of Lyme Disease Spirochetes: Comparative Genomics of Borrelia burgdorferi Plasmids

(2012) Sherwood R. Casjens et al.   PLoS One

RpoS Regulates Essential Virulence Factors Remaining to Be Identified in Borrelia burgdorferi

(2012) Qilong Xu et al.   PLoS One

Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

(2012) Tao Lin et al.   PLoS One

The heterogeneous motility of the Lyme disease spirochete in gelatin mimics dissemination through tissue

(2012) M. W. Harman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Borrelia burgdorferi Requires the Alternative Sigma Factor RpoS for Dissemination within the Vector during Tick-to-Mammal Transmission

(2012) Star M. Dunham-Ems et al.   PLoS Pathogens

STAS Domain Structure and Function

(2011) Alok K. Sharma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oligopeptide Permease A5 Modulates Vertebrate Host-Specific Adaptation of Borrelia burgdorferi

(2011) B. V. Subba Raju et al.   INFECTION AND IMMUNITY

The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

(2011) Melissa J. Caimano et al.   INFECTION AND IMMUNITY

The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host

(2011) Christian H. Eggers et al.   MOLECULAR MICROBIOLOGY

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes

(2011) Jessica L. Kostick et al.   MOLECULAR MICROBIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Two-photon absorption properties of fluorescent proteins

(2011) Mikhail Drobizhev et al.   NATURE METHODS

Functional Analysis of the Borrelia burgdorferi bba64 Gene Product in Murine Infection via Tick Infestation

(2011) Toni G. Patton et al.   PLoS One

BosR (BB0647) Controls the RpoN-RpoS Regulatory Pathway and Virulence Expression in Borrelia burgdorferi by a Novel DNA-Binding Mechanism

(2011) Zhiming Ouyang et al.   PLoS Pathogens

Borrelia burgdorferi Requires Glycerol for Maximum Fitness During The Tick Phase of the Enzootic Cycle

(2011) Christopher J. Pappas et al.   PLoS Pathogens

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks

(2011) Ming He et al.   PLoS Pathogens

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Gene Regulation inBorrelia burgdorferi

(2010) D. Scott Samuels   Annual Review of Microbiology

Accessing the SEED Genome Databases via Web Services API: Tools for Programmers

(2010) Terry Disz et al.   BMC BIOINFORMATICS

Role of the Surface Lipoprotein BBA07 in the Enzootic Cycle of Borrelia burgdorferi

(2010) H. Xu et al.   INFECTION AND IMMUNITY

Evolution of the RpoS Regulon: Origin of RpoS and the Conservation of RpoS-Dependent Regulation in Bacteria

(2010) Sarah M. Chiang et al.   JOURNAL OF MOLECULAR EVOLUTION

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

CDD: a Conserved Domain Database for the functional annotation of proteins

(2010) A. Marchler-Bauer et al.   NUCLEIC ACIDS RESEARCH

The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission

(2010) R. D. Gilmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution and Distribution of the ospC Gene, a Transferable Serotype Determinant of Borrelia burgdorferi

(2010) A. G. Barbour et al.   mBio

Fast, adaptive evolution at a bacterial host-resistance locus: The PFam54 gene array in Borrelia burgdorferi

(2009) Ewa Wywial et al.   GENE

Overexpression of CsrA (BB0184) Alters the Morphology and Antigen Profiles of Borrelia burgdorferi

(2009) E. Sanjuan et al.   INFECTION AND IMMUNITY

Borrelia burgdorferi bba74 Is Expressed Exclusively during Tick Feeding and Is Regulated by Both Arthropod- and Mammalian Host-Specific Signals

(2009) V. B. Mulay et al.   JOURNAL OF BACTERIOLOGY

Rrp2, a  54-Dependent Transcriptional Activator of Borrelia burgdorferi, Activates rpoS in an Enhancer-Independent Manner

(2009) J. S. Blevins et al.   JOURNAL OF BACTERIOLOGY

Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks

(2009) Star M. Dunham-Ems et al.   JOURNAL OF CLINICAL INVESTIGATION

BosR (BB0647) governs virulence expression in Borrelia burgdorferi

(2009) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete

(2009) Jenny A. Hyde et al.   MOLECULAR MICROBIOLOGY

Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator ofBorrelia burgdorfericore cellular functions

(2009) Elizabeth A. Rogers et al.   MOLECULAR MICROBIOLOGY

Borrelia burgdorferismall lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice

(2009) Kamoltip Promnares et al.   MOLECULAR MICROBIOLOGY

Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection

(2008) Jon S Blevins et al.   BMC MICROBIOLOGY

Borrelia burgdorferi Surface-Localized Proteins Expressed during Persistent Murine Infection Are Conserved among Diverse Borrelia spp.

(2008) J. L. Hughes et al.   INFECTION AND IMMUNITY

Borrelia burgdorferi Lacking DbpBA Exhibits an Early Survival Defect during Experimental Infection

(2008) E. H. Weening et al.   INFECTION AND IMMUNITY

Both Decorin-Binding Proteins A and B Are Critical for the Overall Virulence of Borrelia burgdorferi

(2008) Y. Shi et al.   INFECTION AND IMMUNITY

Outer Surface Protein A Protects Lyme Disease Spirochetes from Acquired Host Immunity in the Tick Vector

(2008) J. M. Battisti et al.   INFECTION AND IMMUNITY

Borrelia burgdorferi expression of the bba64, bba65, bba66, and bba73 genes in tissues during persistent infection in mice

(2008) Robert D. Gilmore et al.   MICROBIAL PATHOGENESIS

Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi

(2008) Z. Ouyang et al.   MICROBIOLOGY-SGM

A Differential Role for BB0365 in the Persistence ofBorrelia burgdorferiin Mice and Ticks

(2007) Utpal Pal et al.   JOURNAL OF INFECTIOUS DISEASES