The Hybrid Histidine Kinase Hk1 Is Part of a Two-Component System That Is Essential for Survival of Borrelia burgdorferi in Feeding Ixodes scapularis Ticks

The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes

(2011) Jessica L. Kostick et al.   MOLECULAR MICROBIOLOGY

Borrelia burgdorferi Requires Glycerol for Maximum Fitness During The Tick Phase of the Enzootic Cycle

(2011) Christopher J. Pappas et al.   PLoS Pathogens

Cyclic di-GMP is Essential for the Survival of the Lyme Disease Spirochete in Ticks

(2011) Ming He et al.   PLoS Pathogens

Cholesterol Lipids of Borrelia burgdorferi Form Lipid Rafts and Are Required for the Bactericidal Activity of a Complement-Independent Antibody

(2010) Timothy J. LaRocca et al.   Cell Host & Microbe

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

A structural classification of substrate-binding proteins

(2010) Ronnie P.-A. Berntsson et al.   FEBS LETTERS

Analysis of a Borrelia burgdorferi phosphodiesterase demonstrates a role for cyclic-di-guanosine monophosphate in motility and virulence

(2010) Syed Z. Sultan et al.   MOLECULAR MICROBIOLOGY

The bba64 gene of Borrelia burgdorferi, the Lyme disease agent, is critical for mammalian infection via tick bite transmission

(2010) R. D. Gilmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Periplasmic domain of the sensor-kinase BvgS reveals a new paradigm for the Venus flytrap mechanism

(2010) J. Herrou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Allosteric Self-Splicing Ribozyme Triggered by a Bacterial Second Messenger

(2010) E. R. Lee et al.   SCIENCE

Role of Acetyl-Phosphate in Activation of the Rrp2-RpoN-RpoS Pathway in Borrelia burgdorferi

(2010) Haijun Xu et al.   PLoS Pathogens

Biological Insights from Structures of Two-Component Proteins

(2009) Rong Gao et al.   Annual Review of Microbiology

The role of saliva in tick feeding

(2009) Ivo et al.   Frontiers in Bioscience-Landmark

Molecular characterization of the tick-Borrelia interface

(2009) Aravinda Manu de Silva   Frontiers in Bioscience-Landmark

CspA-Mediated Binding of Human Factor H Inhibits Complement Deposition and Confers Serum Resistance in Borrelia burgdorferi

(2009) M. R. Kenedy et al.   INFECTION AND IMMUNITY

Borrelia burgdorferi bba74 Is Expressed Exclusively during Tick Feeding and Is Regulated by Both Arthropod- and Mammalian Host-Specific Signals

(2009) V. B. Mulay et al.   JOURNAL OF BACTERIOLOGY

Rrp2, a  54-Dependent Transcriptional Activator of Borrelia burgdorferi, Activates rpoS in an Enhancer-Independent Manner

(2009) J. S. Blevins et al.   JOURNAL OF BACTERIOLOGY

Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks

(2009) Star M. Dunham-Ems et al.   JOURNAL OF CLINICAL INVESTIGATION

Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator ofBorrelia burgdorfericore cellular functions

(2009) Elizabeth A. Rogers et al.   MOLECULAR MICROBIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

Structural and mechanistic determinants of c-di-GMP signalling

(2009) Tilman Schirmer et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis of ligand binding by a c-di-GMP riboswitch

(2009) Kathryn D Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of a histidine kinase sensor domain with similarity to periplasmic binding proteins

(2009) Jonah Cheung et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Rewiring the Specificity of Two-Component Signal Transduction Systems

(2008) Jeffrey M. Skerker et al.   CELL

Molecular characterization and related aspects of the innate immune response in ticks

(2008) Daniel et al.   Frontiers in Bioscience-Landmark

Borrelia burgdorferi Lacking DbpBA Exhibits an Early Survival Defect during Experimental Infection

(2008) E. H. Weening et al.   INFECTION AND IMMUNITY

Essential Role of the Response Regulator Rrp2 in the Infectious Cycle of Borrelia burgdorferi

(2008) B. K. Boardman et al.   INFECTION AND IMMUNITY

Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi

(2008) Z. Ouyang et al.   MICROBIOLOGY-SGM

Borrelia burgdorferi membranes are the primary targets of reactive oxygen species

(2008) Julie A. Boylan et al.   MOLECULAR MICROBIOLOGY

NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi

(2008) E. Tupin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative sialomics between hard and soft ticks: Implications for the evolution of blood-feeding behavior

(2007) Ben J. Mans et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal Structures and Mutational Analysis of the Arginine-, Lysine-, Histidine-binding Protein ArtJ from Geobacillus stearothermophilus. Implications for Interactions of ArtJ with its Cognate ATP-binding Cassette Transporter, Art(MP)2

(2007) Ardeschir Vahedi-Faridi et al.   JOURNAL OF MOLECULAR BIOLOGY