DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity

Establishment of an in vitro RNA polymerase transcription system: a new tool to study transcriptional activation in Borrelia burgdorferi

(2020) William K. Boyle et al.   Scientific Reports

(p)ppGpp: the magic governor of bacterial growth economy

(2019) Manlu Zhu et al.   CURRENT GENETICS

Transcriptional regulation contributes to prioritized detoxification of hydrogen peroxide over nitric oxide.

(2019) Kristin J. Adolfsen et al.   JOURNAL OF BACTERIOLOGY

Genome-wide effects on Escherichia coli transcription from ppGpp binding to its two sites on RNA polymerase

(2019) Patricia Sanchez-Vazquez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA

(2018) Vadim Molodtsov et al.   MOLECULAR CELL

The oligopeptide ABC transporter OppA4 negatively regulates the virulence factor OspC production of the Lyme disease pathogen

(2018) Bibi Zhou et al.   Ticks and Tick-Borne Diseases

Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress

(2018) Liam F. Fitzsimmons et al.   mBio

Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region

(2018) Timothy Tapscott et al.   Scientific Reports

The Stringent Response-Regulated sRNA Transcriptome of Borrelia burgdorferi

(2018) Dan Drecktrah et al.   Frontiers in Cellular and Infection Microbiology

The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection

(2018) Hui Zhi et al.   Frontiers in Immunology

Transcriptional Responses to ppGpp and DksA

(2018) Richard L. Gourse et al.   Annual Review of Microbiology

DksA controls the response of the Lyme disease spirochete Borrelia burgdorferi to starvation

(2018) William K. Boyle et al.   JOURNAL OF BACTERIOLOGY

Region 3.2 of the σ factor controls the stability of rRNA promoter complexes and potentiates their repression by DksA

(2018) Danil Pupov et al.   NUCLEIC ACIDS RESEARCH

Puzzling conformational changes affecting proteins binding to the RNA polymerase

(2018) Llorenç Fernández-Coll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi , the Lyme Disease Spirochete

(2017) Arianna P. Grove et al.   mBio

Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter

(2017) Ashley M. Groshong et al.   mBio

Weak Organic Acids Decrease Borrelia burgdorferi Cytoplasmic pH, Eliciting an Acid Stress Response and Impacting RpoN- and RpoS-Dependent Gene Expression

(2017) Daniel P. Dulebohn et al.   Frontiers in Microbiology

ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response

(2016) Wilma Ross et al.   MOLECULAR CELL

Virulence of the Lyme disease spirochete before and after the tick bloodmeal: a quantitative assessment

(2016) Irene N. Kasumba et al.   Parasites & Vectors

Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content

(2016) Matthew A. Crawford et al.   mBio

Two Different Virulence-Related Regulatory Pathways in Borrelia burgdorferi Are Directly Affected by Osmotic Fluxes in the Blood Meal of Feeding Ixodes Ticks

(2016) Sébastien Bontemps-Gallo et al.   PLoS Pathogens

DksA and (p)ppGpp Have Unique and Overlapping Contributions to Haemophilus ducreyi Pathogenesis in Humans

(2015) Concerta L. Holley et al.   INFECTION AND IMMUNITY

BadR (BB0693) controls growth phase-dependent induction ofrpoSandbosRinBorrelia burgdorferivia recognizing TAAAATAT motifs

(2015) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Characterization of the RelBbu Regulon in Borrelia burgdorferi Reveals Modulation of Glycerol Metabolism by (p)ppGpp

(2015) Julia V. Bugrysheva et al.   PLoS One

pH Dependence of the Stress Regulator DksA

(2015) Ran Furman et al.   PLoS One

The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation

(2015) Dan Drecktrah et al.   PLoS Pathogens

Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferi

(2015) Crystal L. Richards et al.   PLoS One

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation

(2014) Radha Iyer et al.   MOLECULAR MICROBIOLOGY

Global Repression of Host-Associated Genes of the Lyme Disease Spirochete through Post-Transcriptional Modulation of the Alternative Sigma Factor RpoS

(2014) Daniel P. Dulebohn et al.   PLoS One

Regulatory Protein BBD18 of the Lyme Disease Spirochete: Essential Role During Tick Acquisition?

(2014) B. M. Hayes et al.   mBio

Borreliahost adaptation Regulator (BadR) regulatesrpoSto modulate host adaptation and virulence factors inBorrelia burgdorferi

(2013) Christine L. Miller et al.   MOLECULAR MICROBIOLOGY

The 4-cysteine zinc-finger motif of the RNA polymerase regulator DksA serves as a thiol switch for sensing oxidative and nitrosative stress

(2013) Calvin A. Henard et al.   MOLECULAR MICROBIOLOGY

Changes in Bacterial Growth Rate Govern Expression of the Borrelia burgdorferi OspC and Erp Infection-Associated Surface Proteins

(2012) B. L. Jutras et al.   JOURNAL OF BACTERIOLOGY

Rrp2, a Prokaryotic Enhancer-Like Binding Protein, Is Essential for Viability of Borrelia burgdorferi

(2012) A. M. Groshong et al.   JOURNAL OF BACTERIOLOGY

Borrelia burgdorferi Requires the Alternative Sigma Factor RpoS for Dissemination within the Vector during Tick-to-Mammal Transmission

(2012) Star M. Dunham-Ems et al.   PLoS Pathogens

Oligopeptide Permease A5 Modulates Vertebrate Host-Specific Adaptation of Borrelia burgdorferi

(2011) B. V. Subba Raju et al.   INFECTION AND IMMUNITY

Regulation of the Virulence Determinant OspC by bbd18 on Linear Plasmid lp17 of Borrelia burgdorferi

(2011) A. Sarkar et al.   JOURNAL OF BACTERIOLOGY

The dksA promoter is negatively feedback regulated by DksA and ppGpp

(2011) Pete Chandrangsu et al.   MOLECULAR MICROBIOLOGY

Borrelia burgdorferi Requires Glycerol for Maximum Fitness During The Tick Phase of the Enzootic Cycle

(2011) Christopher J. Pappas et al.   PLoS Pathogens

Gene Regulation inBorrelia burgdorferi

(2010) D. Scott Samuels   Annual Review of Microbiology

ppGpp Conjures Bacterial Virulence

(2010) Z. D. Dalebroux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Growth Phase and (p)ppGpp Control of IraD, a Regulator of RpoS Stability, in Escherichia coli

(2009) H. Merrikh et al.   JOURNAL OF BACTERIOLOGY

Live imaging reveals a biphasic mode of dissemination of Borrelia burgdorferi within ticks

(2009) Star M. Dunham-Ems et al.   JOURNAL OF CLINICAL INVESTIGATION

BosR (BB0647) governs virulence expression in Borrelia burgdorferi

(2009) Zhiming Ouyang et al.   MOLECULAR MICROBIOLOGY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection

(2008) Jon S Blevins et al.   BMC MICROBIOLOGY

Essential Role of the Response Regulator Rrp2 in the Infectious Cycle of Borrelia burgdorferi

(2008) B. K. Boardman et al.   INFECTION AND IMMUNITY

Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi

(2008) Z. Ouyang et al.   MICROBIOLOGY-SGM

The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli

(2008) Matthew F. Traxler et al.   MOLECULAR MICROBIOLOGY