Structural insights into the signalling mechanisms of two-component systems

Multiscale approach to the activation and phosphotransfer mechanism of CpxA histidine kinase reveals a tight coupling between conformational and chemical steps

(2018) Franco Marsico et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Coiled-Coil Antagonism Regulates Activity of Venus Flytrap-Domain-Containing Sensor Kinases of the BvgS Family

(2018) Elodie Lesne et al.   mBio

Signaling ammonium across membranes through an ammonium sensor histidine kinase

(2018) Tobias Pflüger et al.   Nature Communications

Sensory Repertoire of Bacterial Chemoreceptors

(2017) Álvaro Ortega et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Sensory domain contraction in histidine kinase CitA triggers transmembrane signaling in the membrane-bound sensor

(2017) Michele Salvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases

(2017) Nathan W. Schmidt et al.   PROTEIN SCIENCE

Mechanism of transmembrane signaling by sensor histidine kinases

(2017) Ivan Gushchin et al.   SCIENCE

Time-Resolved X-Ray Solution Scattering Reveals the Structural Photoactivation of a Light-Oxygen-Voltage Photoreceptor

(2017) Oskar Berntsson et al.   STRUCTURE

Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase

(2017) Ariel E. Mechaly et al.   STRUCTURE

Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase

(2017) Oskar Berntsson et al.   Nature Communications

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview

(2017) Sandeep Tiwari et al.   Frontiers in Microbiology

Conformational dynamics of the essential sensor histidine kinase WalK

(2017) Yongfei Cai et al.   Acta Crystallographica Section D-Structural Biology

New Insights on Signal Propagation by Sensory Rhodopsin II/Transducer Complex

(2017) A. Ishchenko et al.   Scientific Reports

Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain

(2016) Jimena Rinaldi et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanisms of Two-Component Signal Transduction

(2016) Christopher P. Zschiedrich et al.   JOURNAL OF MOLECULAR BIOLOGY

Delineating PAS-HAMP interaction surfaces and signalling-associated changes in the aerotaxis receptor Aer

(2016) Darysbel Garcia et al.   MOLECULAR MICROBIOLOGY

Balance between Coiled-Coil Stability and Dynamics Regulates Activity of BvgS Sensor Kinase in Bordetella

(2016) E. Lesne et al.   mBio

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

(2016) Felipe Trajtenberg et al.   eLife

Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens

(2016) Nadya Velikova et al.   Scientific Reports

A Trigger Residue for Transmembrane Signaling in the Escherichia coli Serine Chemoreceptor

(2015) Smiljka Kitanovic et al.   JOURNAL OF BACTERIOLOGY

A coiled coil switch mediates cold sensing by the thermosensory protein DesK

(2015) Emilio Saita et al.   MOLECULAR MICROBIOLOGY

Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen

(2015) Jonathan W. Willett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane signaling in the sensor kinase DcuS ofEscherichia coli: A long-range piston-type displacement of transmembrane helix 2

(2015) Christian Monzel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signal Transduction in Histidine Kinases: Insights from New Structures

(2015) Manasi P. Bhate et al.   STRUCTURE

Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update

(2015) John S. Parkinson et al.   TRENDS IN MICROBIOLOGY

HAMP Domain Rotation and Tilting Movements Associated with Signal Transduction in the PhoQ Sensor Kinase

(2015) Susana Matamouros et al.   mBio

Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS

(2015) Elian Dupré et al.   PLoS Pathogens

Bacterial Histidine Kinases as Novel Antibacterial Drug Targets

(2014) Agnieszka E. Bem et al.   ACS Chemical Biology

Crystallographic snapshot of the Escherichia coli EnvZ histidine kinase in an active conformation

(2014) Hedda U. Ferris et al.   JOURNAL OF STRUCTURAL BIOLOGY

Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs through Opposite Helical Transduction Motions

(2014) Boyuan Wang et al.   MOLECULAR CELL

Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation

(2014) Giomar Rivera-Cancel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ

(2014) Kathleen S. Molnar et al.   STRUCTURE

Allosteric Activation of Bacterial Response Regulators: the Role of the Cognate Histidine Kinase Beyond Phosphorylation

(2014) Felipe Trajtenberg et al.   mBio

Mutational analysis of dimeric linkers in peri- and cytoplasmic domains of histidine kinase DctB reveals their functional roles in signal transduction

(2014) J. Liu et al.   Open Biology

Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation

(2014) Ariel E. Mechaly et al.   PLOS BIOLOGY

Helix Bundle Loops Determine Whether Histidine Kinases Autophosphorylate in cis or in trans

(2013) Orr Ashenberg et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation

(2013) P. G. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full-Length Structure of a Sensor Histidine Kinase Pinpoints Coaxial Coiled Coils as Signal Transducers and Modulators

(2013) Ralph P. Diensthuber et al.   STRUCTURE

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

(2013) Thomas Lemmin et al.   PLoS Computational Biology

Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis

(2012) A. E. Dago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system

(2012) E. C. Lowe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Asymmetry-to-Symmetry Switch in Signal Transmission by the Histidine Kinase Receptor for TMAO

(2012) Jason O. Moore et al.   STRUCTURE

Mechanism of Regulation of Receptor Histidine Kinases

(2012) Hedda U. Ferris et al.   STRUCTURE

Genetic and Biochemical Dissection of a HisKA Domain Identifies Residues Required Exclusively for Kinase and Phosphatase Activities

(2012) Jonathan W. Willett et al.   PLoS Genetics

Just scratching the surface: an expanding view of the Cpx envelope stress response

(2011) Stefanie L. Vogt et al.   FEMS MICROBIOLOGY LETTERS

The Mechanisms of HAMP-Mediated Signaling in Transmembrane Receptors

(2011) Hedda U. Ferris et al.   STRUCTURE

Signaling Mechanisms of HAMP Domains in Chemoreceptors and Sensor Kinases

(2010) John S. Parkinson   Annual Review of Microbiology

Bacterial Sensor Kinases: Diversity in the Recognition of Environmental Signals

(2010) Tino Krell et al.   Annual Review of Microbiology

Sensor domains of two-component regulatory systems

(2010) Jonah Cheung et al.   CURRENT OPINION IN MICROBIOLOGY

Molecular strategies for phosphorylation-mediated regulation of response regulator activity

(2010) Rong Gao et al.   CURRENT OPINION IN MICROBIOLOGY

Two-component signal transduction

(2010) Robert B Bourret et al.   CURRENT OPINION IN MICROBIOLOGY

Diversity of structure and function of response regulator output domains

(2010) Michael Y Galperin   CURRENT OPINION IN MICROBIOLOGY

The mechanism of signal transduction by two-component systems

(2010) Patricia Casino et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural and Enzymatic Insights into the ATP Binding and Autophosphorylation Mechanism of a Sensor Histidine Kinase

(2010) Felipe Trajtenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Characterization of the Predominant Family of Histidine Kinase Sensor Domains

(2010) Zhen Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive Analysis of HAMP Domains: Implications for Transmembrane Signal Transduction

(2010) Stanislaw Dunin-Horkawicz et al.   JOURNAL OF MOLECULAR BIOLOGY

From signal perception to signal transduction: ligand-induced dimeric switch of DctB sensory domain in solution

(2010) Beiyan Nan et al.   MOLECULAR MICROBIOLOGY

Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ

(2010) S. D. Goldberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved mechanism for sensor phosphatase control of two-component signaling revealed in the nitrate sensor NarX

(2010) T. N. Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Concatenated HAMP Domains Provides a Mechanism for Signal Transduction

(2010) Michael V. Airola et al.   STRUCTURE

Biological Insights from Structures of Two-Component Proteins

(2009) Rong Gao et al.   Annual Review of Microbiology

Engineered Socket Study of Signaling through a Four-Helix Bundle: Evidence for a Yin−Yang Mechanism in the Kinase Control Module of the Aspartate Receptor

(2009) Kalin E. Swain et al.   BIOCHEMISTRY

Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction

(2009) Patricia Casino et al.   CELL

The S Helix Mediates Signal Transmission as a HAMP Domain Coiled-Coil Extension in the NarX Nitrate Sensor from Escherichia coli K-12

(2009) V. Stewart et al.   JOURNAL OF BACTERIOLOGY

Mutational analyses of HAMP helices suggest a dynamic bundle model of input-output signalling in chemoreceptors

(2009) Qin Zhou et al.   MOLECULAR MICROBIOLOGY

Structural plasticity and catalysis regulation of a thermosensor histidine kinase

(2009) D. Albanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of PAS-Linked Histidine Kinase and the Response Regulator Complex

(2009) Seiji Yamada et al.   STRUCTURE

Structural Analysis of Ligand Stimulation of the Histidine Kinase NarX

(2009) Jonah Cheung et al.   STRUCTURE

Structure and Signaling Mechanism of Per-ARNT-Sim Domains

(2009) Andreas Möglich et al.   STRUCTURE

Changes in Quaternary Structure in the Signaling Mechanisms of PAS Domains†,‡

(2008) Rebecca A. Ayers et al.   BIOCHEMISTRY

Allosteric Regulation of Histidine Kinases by Their Cognate Response Regulator Determines Cell Fate

(2008) Ralf Paul et al.   CELL

Design and Signaling Mechanism of Light-Regulated Histidine Kinases

(2008) Andreas Möglich et al.   JOURNAL OF MOLECULAR BIOLOGY

Polar accumulation of the metabolic sensory histidine kinases DcuS and CitA in Escherichia coli

(2008) P. Scheu et al.   MICROBIOLOGY-SGM

Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS

(2008) Manuel Etzkorn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY