Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy

(2018) Srikanth Battu et al.   PLOS BIOLOGY

COX-2–PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis

(2018) Yuan Li et al.   EBioMedicine

RIG-I–like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation

(2017) Joris K. Sprokholt et al.   JOURNAL OF IMMUNOLOGY

HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection

(2017) Guochun Jiang et al.   mBio

GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

(2017) A. Jaspart et al.   Scientific Reports

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection

(2017) Sebastian Aguirre et al.   Nature Microbiology

Cyclooxygenase‐2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents

(2017) Chun-Kuang Lin et al.   Scientific Reports

Activation of COX-2/PGE 2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production

(2016) Mia Madel Alfajaro et al.   JOURNAL OF VIROLOGY

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Transcriptome meta-analysis reveals a dysregulation in extra cellular matrix and cell junction associated gene signatures during Dengue virus infection

(2016) Sumbul Afroz et al.   Scientific Reports

Keeping the eIF2 alpha kinase Gcn2 in check

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Isolation of Human Monocytes by Double Gradient Centrifugation and Their Differentiation to Macrophages in Teflon-coated Cell Culture Bags

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Listeriaphospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures

(2013) Ivan Tattoli et al.   EMBO JOURNAL

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro

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Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascadesin vitrohighlights the significance of these cascades beyond inflammation

(2009) Wan-Lin Wu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells

(2008) Regina A. Oyesanya et al.   FASEB JOURNAL