Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID‐19

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

(2020) Dominic G. Roy et al.   Cell Metabolism

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

(2020) Yvan Jamilloux et al.   AUTOIMMUNITY REVIEWS

The mechanistic target of rapamycin (mTOR): Novel Considerations as an Antiviral Treatment and Possibilities for COVID-19

(2020) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Immunoregulation with mTOR inhibitors to prevent COVID‐19 severity: A novel intervention strategy beyond vaccines and specific antiviral medicines

(2020) Yunfeng Zheng et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Obesity and its Implications for COVID‐19 Mortality

(2020) William Dietz et al.   Obesity

Risk of COVID‐19 for patients with obesity

(2020) Radwan Kassir   Obesity Reviews

Obesity and COVID-19: ACE 2, the Missing Tile

(2020) Antonio Iannelli et al.   OBESITY SURGERY

An Open Question: Is It Rational to Inhibit the mTor-Dependent Pathway as COVID-19 Therapy?

(2020) Giuseppe Terrazzano et al.   Frontiers in Pharmacology

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

(2020) Wen Wen et al.   Cell Discovery

From causes of aging to death from COVID-19

(2020) Mikhail V. Blagosklonny   Aging-US

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Obesity and COVID‐19: The mTOR pathway as a possible culprit

(2020) Alireza Bolourian et al.   Obesity Reviews

Dengue Virus Induced COX-2 Signaling Is Regulated Through Nutrient Sensor GCN2

(2020) Sumbul Afroz et al.   Frontiers in Immunology

COVID-19 and Obesity: Dangerous Liaisons

(2020) Grazia Caci et al.   Journal of Clinical Medicine

Amino acid starvation enhances vaccine efficacy by augmenting neutralizing antibody production

(2019) Sumbul Afroz et al.   Science Signaling

Healing the Heart with Sirtuins and Mammalian Forkhead Transcription Factors

(2019) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy

(2018) Srikanth Battu et al.   PLOS BIOLOGY

Implications of amino acid sensing and dietary protein to the aging process

(2018) Oleh Lushchak et al.   EXPERIMENTAL GERONTOLOGY

Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat

(2018) Yuebo Zhang et al.   Frontiers in Physiology

GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice

(2018) Zhengyang Lu et al.   EXPERIMENTAL NEUROLOGY

Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice

(2017) Inna A. Nikonorova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acid Sensing via General Control Nonderepressible-2 Kinase and Immunological Programming

(2017) Srikanth Battu et al.   Frontiers in Immunology

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation

(2016) Rajesh Ravindran et al.   NATURE

Convertible visceral fat as a therapeutic target to curb obesity

(2016) Antonio Giordano et al.   NATURE REVIEWS DRUG DISCOVERY

Associations among the plasma amino acid profile, obesity, and glucose metabolism in Japanese adults with normal glucose tolerance

(2016) Chisa Takashina et al.   Nutrition & Metabolism

The S6K protein family in health and disease

(2015) Mariana R. Tavares et al.   LIFE SCIENCES

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

(2015) Buvana Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

(2014) Alfred J. Meijer et al.   AMINO ACIDS

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

The eIF2α kinases inhibit vesicular stomatitis virus replication independently of eIF2 phosphorylation.

(2014) Jothi Krishnamoorthy et al.   CELL CYCLE

Crosstalk between the Tor and Gcn2 pathways in response to different stresses

(2014) Gro Elise Rødland et al.   CELL CYCLE

Compelling Results of Adjuvant Therapy With Sirolimus for Severe H1N1 Pneumonia

(2014) Yu-Chung Chuang et al.   CRITICAL CARE MEDICINE

A New Era in Brown Adipose Tissue Biology: Molecular Control of Brown Fat Development and Energy Homeostasis

(2013) Shingo Kajimura et al.   Annual Review of Physiology

Adjuvant Treatment With a Mammalian Target of Rapamycin Inhibitor, Sirolimus, and Steroids Improves Outcomes in Patients With Severe H1N1 Pneumonia and Acute Respiratory Failure*

(2013) Chun-Hua Wang et al.   CRITICAL CARE MEDICINE

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation

(2013) R. Ravindran et al.   SCIENCE

Quantitative Metabolomic Profiling of Serum, Plasma, and Urine by 1H NMR Spectroscopy Discriminates between Patients with Inflammatory Bowel Disease and Healthy Individuals

(2012) Rudolf Schicho et al.   JOURNAL OF PROTEOME RESEARCH

GCN2 Has Inhibitory Effect on Human Immunodeficiency Virus-1 Protein Synthesis and Is Cleaved upon Viral Infection

(2012) Javier del Pino et al.   PLoS One

Tinkering with Translation: Protein Synthesis in Virus-Infected Cells

(2012) D. Walsh et al.   Cold Spring Harbor Perspectives in Biology

Dietary factors and low-grade inflammation in relation to overweight and obesity

(2011) Philip C. Calder et al.   BRITISH JOURNAL OF NUTRITION

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways

(2011) Fei Xiao et al.   DIABETES

Chronic Inflammation in Obesity and the Metabolic Syndrome

(2010) Rosário Monteiro et al.   MEDIATORS OF INFLAMMATION

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

(2009) Y. Cheng et al.   DIABETES

Severe Acute Respiratory Syndrome Coronavirus Triggers Apoptosis via Protein Kinase R but Is Resistant to Its Antiviral Activity

(2008) V. Krahling et al.   JOURNAL OF VIROLOGY